[Patterns of the variation in kinetic growth parameters in populations of clones of transplantable rat tumors in vivo]. / Zakonomernosti varirovaniia kineticheskikh parametrov rosta v populiatsiiakh klonov perevivnykh opukholei krys in vivo.

Clones of the rat transplantable tumors: Walker's carcinosarcoma, rhabdomyosarcoma RA-2 and ovary carcinoma, were obtained by means of the lung colony technique and then transplanted subcutaneously and intraperitoneally. Growth parameters of the clones and their transplantants were measured (T, phi = ln2/T, V1). All the tumors gave populations of clones and transplantants with high variability of growth kinetics. There was a positive correlation between growth kinetics of the I and II generation transplantants, and the selection by growth kinetic parameters proved effective. The growth kinetic parameters seem to be quantitative indices with relatively low heritability, and populations of tumor clonogenic cells are heritably heterogeneous by their growth kinetic parameters.

[Results of selection for affinity in cell populations of rat transplantable tumors]. / Rezul'taty otbora na affinitet v kletochnykh populiatsiiakh nekotorykh transplantruemykh opukholei krys.

Results of selection for the affinity for lung tissue in cells of three transplanted tumors of the rat are given. Tumor cell suspensions were injected intravenously-intraperitoneally or subcutaneously-intravenously (the clonal line -- clone circuit), or intravenously-intravenously (the clone-clone circuit). The efficiency of the method has been shown in the cases of the Worker carcinoma and of a 20-methylcholantren-induced rhabdosarcoma. A 10-fold recloning of cells of the ovary ascite tumor failed to increase their affinity for the lung tissue. It is suggested that a hereditary heterogeneity with the trait "the affinity for lung tissue" may be characteristic of tumor cell populations.