Hyaluronic Acid-Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release.

The use of a controlled-release drug carrier is an innovative solution for the treatment of local infections, in particular in dentistry, skin diseases, and in open wounds. The biocompatibility, biodegradability, the possibility of a large amount of drug adsorbed (especially those with hydrophilic properties), and the ability to create structures of any shape and size are the reasons for hydrogels to be frequently studied. The main disadvantage of hydrogel carriers is the rapid rate of drug release; hence, in this study, an attempt was made to additionally chemically cross-link 1-ethyl-3-(3-dimethyl aminopropyl)-1-carbodiimide hydrochloride (EDC) with the hyaluronic acid-alginate (HA-SAL) structure. The answer to significantly reduce the mass flux typical for hydrogel structure was to surround it with a polymer layer using a dry cover. By coating the carriers with polylactide, the release time was increased by around forty times. As the carriers were designed to reduce local bacterial infections, among others in dentistry, the released antibiotics were amoxycillin, metronidazole, and doxycycline.

Bio-accessibility and health risk assessment of some selected heavy metals in indoor dust from higher institutions in Ondo State, Nigeria.

Risks of heavy metal exposure from contaminated indoor dust constitute a major threat to human health. In this paper, heavy metals in deposited indoor dust samples from four tertiary institutions in Ondo State, Nigeria-Federal University of Technology, Akure; Federal College of Agriculture, Akure; Ondo State College of Health Science Technology, Akure; and Adeyemi College of Education, Ondo-were examined. The samples were collected from each location by dusting the surfaces of doors, windows, and bookshelves in lecture rooms, hostels, laboratories, and libraries, homogenized into a representative composite, and analyzed for Cr, Pb, Cd, Cu, and Zn using a flame atomic absorption spectrophotometer (FAAS) to assess their potential health risk to humans. Cu had the highest mean metal concentration in the range (0.18-0.31 mg/kg) and Cd had the lowest (ND-0.02 mg/kg) in the study. Samples from Federal College of Agriculture had the highest metal concentration, while those from Ondo State College of Health Science Technology had the lowest. The average daily dose (ADD) through ingestion was determined to be the key exposure pathway in a non-carcinogenic investigation followed by ADD through dermal contact and ADD via inhalation accordingly. Despite this, the hazard quotients (HQ) and hazard indices (HI) were well below the safety limit of one. The study established that carcinogenic effect cannot be experienced with exposure to the studied dust samples. To retain the status, it is suggested that a reasonable level of safety and tight rules be implemented.