RESUMO
This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients (102 with venous thrombosis and 26 with arterial thrombosis) attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients (20.3%) than controls (6.0%). The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified.
Assuntos
Fator V/genética , Predisposição Genética para Doença , Trombose , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Frequência do Gene/genética , Predisposição Genética para Doença/epidemiologia , Predisposição Genética para Doença/genética , Testes Genéticos , Humanos , Lactente , Pacientes Internados/estatística & dados numéricos , Pessoa de Meia-Idade , Linhagem , Reação em Cadeia da Polimerase , Prevalência , Fatores de Risco , Trombose/epidemiologia , Trombose/genética , Tunísia/epidemiologiaRESUMO
This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients [102 with venous thrombosis and 26 with arterial thrombosis] attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients [20.3%] than controls [6.0%]. The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified
