1.
Bioorg Med Chem Lett
; 17(10): 2781-4, 2007 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17419054
RESUMO
Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of alpha-GalCer (1)/hCD1d complex is also described.
Assuntos
Citocinas/metabolismo , Glicolipídeos/metabolismo , Fatores Imunológicos/metabolismo , Esfingosina/análogos & derivados , Células Th2/metabolismo , Animais , Humanos , Estrutura Molecular , Esfingosina/química
2.