An investigation of the effects of the local use of 1:25 dihydroxycholecalciferol (1:25 D) on tension sites during experimental tooth movement in rats.

The aim of this work was to investigate the local effects of 1:25 dihydroxychole-calciferol, one of the most potent osteoclastic activity stimulants. Tests were conducted on 32 Wistar albino rats divided into 3 groups: an experimental (appliance + drug, n = 11), control (appliance only, n = 11) and a no therapy group (n = 10) which was used for purposes of interpreting histological findings in the others. A significantly higher area of unilateral apposition, relative to the control group, was observed in the experimental group local to the area of administration of the 1:25 D.

Effects of thalassaemia major on components of the craniofacial complex.

The purpose of this study was to evaluate the craniofacial effects of thalassaemia major and involved a cephalometric analysis of two samples, consisting of 30 thalassaemic patients and 30 control cases. Differences between the groups were tested by Variance analysis (two factors completely randomized design). It was found that thalassaemia major had significant effects on components of the craniofacial complex: The typical thalassaemic patient had a moderate Class 2 skeletal discrepancy with pronounced vertical mandibular growth direction, prominent mandibular incisors, everted lips, and a narrowed nasal cavity.