RESUMO
The influence of ethanol on glycogen value in liver and skeletal muscle was investigated at rats and forensic cases. In 24 hours after ethanol intake glycogen value in rat's liver was low. By autopsy examinations liver glycogen value was low in cases as acute ethanol poisoning as coronary heard diseases with alcohol condition. No differences in muscle glycogen level were revealed. The results may be used in postmortem interval at differential diagnosis when blood alcohol is absence or traces.
Assuntos
Intoxicação Alcoólica/metabolismo , Glicogênio/metabolismo , Fígado/metabolismo , Músculo Esquelético/metabolismo , Doença Aguda , Intoxicação Alcoólica/sangue , Intoxicação Alcoólica/complicações , Intoxicação Alcoólica/patologia , Animais , Autopsia , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/patologia , Diagnóstico Diferencial , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Etanol/sangue , Etanol/intoxicação , Patologia Legal , Glicogênio/sangue , Humanos , Fígado/patologia , Músculo Esquelético/patologia , RatosRESUMO
The biochemical test of the vitreous body (VB) may be used in post-mortem diagnosis of diabetes mellitus and diabetic coma. Concentrations of glucose, lactate, keton bodies in the VB of the eye do not depend on duration of post-mortem period. Methods of diagnosis of hyperglycemic, hypoglycemic and ketoacidotic comas in the postmortem period are proposed. VB glucose over 17 mmol/l is a specific marker indicating death due to diabetic coma with hyperglycemia. Blood lactate under 16 mmol/l and glucose absence in the VB specifically mark death of hypoglycemic coma. In death of diabetic coma with ketoacidosis, a sharp rise in the level of VB ketonic bodies was observed.
Assuntos
Bioquímica/métodos , Coma Diabético/patologia , Corpo Vítreo/química , Glicemia/análise , Coma Diabético/diagnóstico , Glucose/análise , Hemoglobinas Glicadas/análise , Glicosúria/diagnóstico , Humanos , Lactatos/análise , Lactatos/sangue , Mudanças Depois da MorteRESUMO
Analysis of the lacrimal fluid was carried out for the diagnosis of diabetes mellitus in 68 patients. Collection of tears is absolutely painless, atraumatic, and involves virtually no risk of viral infections. Analysis of the lacrimal fluid is particularly valuable for repeated analyses over the course of disease. A method for postmortem diagnosis of diabetes mellitus and hyperglycemic coma by measuring glucose in the vitreous body is suggested. The content of glucose in the vitreous higher than 17 mmol/liter is a specific marker indicating death from hyperglycemic coma.
