RESUMO
UNLABELLED: We present a rare case of primary non-Hodgkins Lymphoma of the frontal sinus diagnosed by Fine needle aspiration cytology (FNAC). FNAC is a safe, simple, rapid and effective technique that could be used to diagnose lesions even in unusual sites like paranasal sinuses with effective radiological guidance. Neoplasms of the frontal sinus could be easily misdiagnosed as an inflammatory process clinically. FNAC is a simple test to rule out a neoplasm. A review of a single case including radiographic, clinical, and pathologic findings was done, followed by a discussion on the pathological differential diagnosis highlighting relevant literature. Timely diagnosis is critical in the management of these cases. KEYWORDS: Fine needle aspiration cytology, non-Hodgkin lymphoma, diffuse large B cell lymphoma, frontal sinus.
Assuntos
Biópsia por Agulha Fina , Linfoma não Hodgkin , Citodiagnóstico , Diagnóstico Diferencial , Seio Frontal , HumanosAssuntos
Neoplasias da Mama/diagnóstico , Fibroadenoma/patologia , Células Gigantes/patologia , Osteoclastos/patologia , Adulto , Biópsia por Agulha Fina , Mama/química , Mama/patologia , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Antígeno Carcinoembrionário/análise , Feminino , Secções Congeladas , Células Gigantes/química , Hemossiderina/análise , Humanos , Imuno-Histoquímica , Macrófagos/química , Receptor ErbB-2/análise , Receptores de Esteroides/análise , alfa 1-Antitripsina/análiseRESUMO
The cytological diagnosis of classical papillary carcinoma is easily established based on the characteristic architectural and nuclear features. However, the follicular variant of papillary thyroid carcinoma(FVPTC) poses a diagnostic challenge. In this study we analysed the cytological features of 14 histopathologically proven cases of FVPTC. We inferred that a combination of architectural features such as follicles and syncytial clusters and nuclear features, viz grooves, pseudoinclusions and enlarged nuclei with fine chromatin, were helpful in establishing the diagnosis. It is hence suggested that based on the combination of the aforesaid features a diagnosis of FVPTC be offered whenever it is possible. This helps in patient management, obviating the need for a second surgical intervention.
Assuntos
Carcinoma Papilar/patologia , Núcleo Celular/patologia , Matriz Nuclear/patologia , Neoplasias da Glândula Tireoide/patologia , Biópsia por Agulha Fina/métodos , HumanosRESUMO
BACKGROUND: Macrofollicular variant of papillary thyroid carcinoma (PTC) is an uncommon, recently described thyroid tumor. By frozen section it can be confused easily with goiter or macrofollicular adenoma. CASE: A 41-year-old female presented with a huge mass in the right thyroid lobe, cold on scintigraphy. By fine needle aspiration fluid was obtained. Smears of the sediment of the fluid showed epithelial cells with morphologic features diagnostic of PTC. Frozen section diagnosis was benign. CONCLUSION: This is the first reported case of macrofollicular variant of PTC diagnosed preoperatively by cytology. In our case the cytology was similar to that of cystic PTC.
Assuntos
Adenocarcinoma Folicular/diagnóstico , Adenocarcinoma Folicular/patologia , Carcinoma Papilar/diagnóstico , Carcinoma Papilar/patologia , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/patologia , Adenocarcinoma Folicular/cirurgia , Adulto , Biópsia por Agulha , Carcinoma Papilar/cirurgia , Diagnóstico Diferencial , Reações Falso-Negativas , Feminino , Secções Congeladas , HumanosRESUMO
A papillary carcinoma of the thyroid characterized by numerous spindle-shaped tumor cells in fine needle aspiration (FNA) smears is reported. The oval nuclei of the spindle cells, arranged in monolayered sheets, occasionally showed "rhythmic," palisaded patterns. Comparative study of cytology and histology of this tumor revealed that the spindle cells observed in FNA smears originated in the epithelium covering the edematous neoplastic papillae.
