The Social Problems of Morbidly Obese Patients on a Community Level: A Cross-Sectional Study in Saudi Arabia.

Objective: To identify the predictors and social problems of obese patients in Saudi Arabia. Methods: A cross-sectional study was conducted for the period between July 2016 and January 2017. The study population consisted of obese patients visiting the surgery clinics following the medical examinations required before obesity surgery. Patients were recruited from four main medical centres in Riyadh: King Fahad Medical City, University Medical City-King Khalid University Hospital, King Abdulaziz Medical City in the National Guard, and Prince Sultan Military Medical City. The study questionnaire tool was developed based on extensive literature. The questionnaire tool explored personal and demographic characteristics of obese patients and the social problems that morbidly obese patients suffer from at the community level. Logistic regression analysis was used to identify predictors of those facing social problems. Results: A total of 374 patients completed the questionnaires. We found that having a bachelor's degree, a body mass index (BMI) of 40 kg/m2 and above, and other comorbidities were important predictors that increased the likelihood of having social problems related to obesity on a community level (p<0.05). On the other hand, having a high income (11,000 SR/per month and above) was a protective factor that was associated with lower odds of having social problems related to obesity on a community level (p<0.05). Conclusion: Obese patients with low socioeconomic status, having a bachelor's degree, and those with comorbidities tend to have social problems. Future studies to investigate the predictors or social problems among obese patients on a larger scale are warranted.

Long-Term Weight Outcomes after Bariatric Surgery: A Single Center Saudi Arabian Cohort Experience.

BACKGROUND: Obesity is considered a global chronic disease requiring weight management through lifestyle modification, pharmacotherapy, or weight loss surgery. The dramatic increase in patients with severe obesity in Saudi Arabia is paralleled with those undergoing bariatric surgery. Although known to be beneficial in the short term, the long-term impacts of surgery within this group and the sustainability of weight loss after surgery remains unclear. OBJECTIVES: We aimed to assess the long-term weight outcomes after bariatric surgery. SETTING: The study was conducted at King Khalid University Hospital (KKUH), King Saud University Medical City (KSUMC) in Riyadh, Saudi Arabia. METHODS: An observational prospective cohort study on adult patients with severe obesity undergoing bariatric surgery (sleeve gastrectomy (SG) or Roux-en Y gastric bypass (RYGB)) during the period between 2009 and 2015 was conducted. Weight loss patterns were evaluated pre- and post-surgery through clinical and anthropometric assessments. Absolute weight loss was determined, and outcome variables: percent excess weight loss (%EWL), percent total weight loss (%TWL), and percent weight regain (%WR), were calculated. Statistical analysis using univariate and multivariate general linear modelling was carried out. RESULTS: A total of 91 (46 males and 45 females) patients were included in the study, with the majority belonging to the SG group. Significant weight reductions were observed at 1 and 3 years of follow-up (p < 0.001) from baseline. The %EWL and %TWL were at their maximum at 3 years (72.4% and 75.8%) and were comparable between the SG and RYGB. Decrements in %EWL and %TWL and increases in %WR were seen from 3 years onwards from bariatric surgery until the study period ended. The yearly follow-up attrition rate was 20.8% at 1 year post-surgery, 26.4% at year 2, 31.8% at year 3, 47.3% at year 4, 62.6% at year 5, and 79.1% at end of study period (at year 6). CONCLUSION: The major challenge to the successful outcome of bariatric surgery is in maintaining weight loss in the long-term and minimizing weight regain. Factors such as the type of surgery and gender need to be considered before and after surgery, with an emphasis on the need for long-term follow-up to enssure the optimal benefits from this intervention.

A Proteomics-Based Approach Reveals Differential Regulation of Urine Proteins between Metabolically Healthy and Unhealthy Obese Patients.

Metabolic dysfunction associated with obesity threatens to inundate health care resources by increasing the incidences of obesity-related diseases. The aim of the present study was to investigate the changes in the urinary proteome of 18 individuals classified into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) patients. Proteome analysis was performed using the two-dimensional difference in gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS). Upon analysis, a total of 54 proteins were found to be affected with ≥1.5-fold change (ANOVA, p ≤ 0.05), of which 44 proteins were upregulated and 10 proteins were downregulated. These differentially abundant proteins were related to nuclear factor κB (NF-κB) and p38 mitogen-activated protein (MAP) kinase pathways and were involved in cellular compromise, inflammatory response, and cancer. Proteins involved in inflammation (fibrinogen alpha (FIBA), serotransferrin (TRFE, and kininogen-1 (KNG1)) and insulin resistance (ADP-ribosylation factor (ARF)-like protein 15 (ARL15) and retinol-binding protein 4 (RET4)) were found to be significantly increased in the urine samples of MUHO compared to MHO patients. Investigating the effects of obesity on urinary proteins can help in developing efficient diagnostic procedures for early detection and prevention of obesity-related complications.

A Proteomics Based Approach Reveals Differential Regulation of Visceral Adipose Tissue Proteins between Metabolically Healthy and Unhealthy Obese Patients.

Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood. In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese patients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation. Two dimensional difference in-gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was carried out. A total of 28 proteins were identified with a statistically significant difference in abundance and a 1.5-fold change (ANOVA, p ≤ 0.05) between the groups. 11 proteins showed increased abundance while 17 proteins were decreased in the metabolically unhealthy obese compared to the healthy obese. The differentially expressed proteins belonged broadly to three functional categories: (i) protein and lipid metabolism (ii) cytoskeleton and (iii) regulation of other metabolic processes. Network analysis by Ingenuity pathway analysis identified the NFκB, IRK/MAPK and PKC as the nodes with the highest connections within the connectivity map. The top network pathway identified in our protein data set related to cellular movement, hematological system development and function, and immune cell trafficking. The VAT proteome between the two groups differed substantially between the groups which could potentially be the reason for metabolic dysfunction.

A proteomic analysis of excreted and circulating proteins from obese patients following two different weight-loss strategies.

Bariatric surgery is the most successful therapeutic approach to weight loss, but how it leads to weight loss, and how it resolves obesity-related complications, including type-2 diabetes, are poorly understood. This study, comprising two groups of individuals, one on a low-calorie diet (n = 5) and one undergoing bariatric surgery (n = 7), used both targeted and untargeted proteomic approaches to determine changes in protein levels pre- and post-intervention (i.e. 3-6 months later). Changes were observed in both circulating and excreted proteins following weight loss. Targeted multiplexed biochip arrays measured 12 plasma peptides/proteins involved in metabolism and inflammation: C-peptide, ferritin, interleukin-6, interleukin-1 alpha, resistin, insulin, tumor necrosis factor alpha, leptin, plasminogen-activator inhibitor-1, adiponectin, cystatin C, and C-reactive protein. Following a low-calorie diet, plasma insulin and C-reactive protein levels were significantly reduced (P = 0.045 and P = 0.030, respectively); adiponectin increased and leptin decreased following surgery (P = 0.014 and P = 0.005, respectively). Untargeted proteomic analysis employing 2D difference in-gel electrophoresis (DIGE) showed 28 protein spots with ≥1.5-fold changes in expression following weight loss by a low-calorie diet; comparison of pre- and post-intervention urine samples from the bariatric surgery group showed changes in excretion of 110 protein spots. The combination of targeted protein analysis by multiplexed arrays and an exploratory (i.e. an unbiased or discovery) proteomic assessment of hundreds of proteins offers valuable insights into the mechanistic differences between alternative weight-loss strategies. This is a powerful hypothesis-generating approach to study complex, multifactorial syndromes such as obesity. The findings that arise from these studies can then be validated in targeted, hypothesis-directed investigations.

Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: adipose depot specificity and gender dimorphism.

Chemerin, a recognized chemoattractant, is expressed in adipose tissue and plays a role in adipocytes differentiation and metabolism. Gender- and adipose tissue-specific differences in human chemerin expression have not been well characterized. Therefore, these differences were assessed in the present study. The body mass index (BMI) and the circulating levels of chemerin and other inflammatory, adiposity and insulin resistance markers were assessed in female and male adults of varying degree of obesity. Chemerin mRNA expression was also measured in paired subcutaneous and visceral adipose tissue samples obtained from a subset of the study subjects. Serum chemerin concentrations correlated positively with BMI and serum leptin levels and negatively with high density lipoprotein (HDL)-cholesterol levels. No correlation was found between serum chemerin concentrations and fasting glucose, total cholesterol, low density lipoprotein (LDL)-cholesterol, triglycerides, insulin, C-reactive protein or adiponectin. Similarly, no relation was observed with the homeostasis model assessment for insulin resistance (HOMA-IR) values. Gender- and adipose tissue-specific differences were observed in chemerin mRNA expression levels, with expression significantly higher in women than men and in subcutaneous than visceral adipose tissue. Interestingly, we found a significant negative correlation between circulating chemerin levels and chemerin mRNA expression in subcutaneous fat. Among the subjects studied, circulating chemerin levels were associated with obesity markers but not with markers of insulin resistance. At the tissue level, fat depot-specific differential regulation of chemerin mRNA expression might contribute to the distinctive roles of subcutaneous vs. visceral adipose tissue in human obesity.

Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans.

Obesity is associated with chronic low-grade inflammation, which contributes to systemic metabolic irregularities and obesity-linked metabolic disorders. Orosomucoid (ORM), an acute phase reactant protein, was shown to be produced in response to metabolic and inflammatory signals in the adipose tissue of obese mice, which protects them from severe inflammation and subsequent metabolic dysfunction. In this study, we examined whether there are site-specific differences between visceral and subcutaneous adipose tissue (VAT and SAT, respectively) ORM gene and protein expression from individuals with a wide range of obesity and the relationship between expressed and circulating ORM levels and measures of adiposity, insulin resistance, and pro- and anti-inflammatory markers and adipokines. The level of circulating ORM correlated positively with BMI, body fat mass, and serum leptin. It also correlated with fasting insulin, HOMA-IR values and C-reactive protein in men. There were no site-specific differences in ORM mRNA and protein expression between VAT and SAT, nor did we find a relationship between circulating ORM levels and its mRNA expression in either fat depot. We found that ORM mRNA expression correlated with mRNA expression of TNF-α, IL-6, and adiponectin in VAT, and with TNF-α and adiponectin in SAT. These observations are the first description linking adipose tissue ORM and pro- and anti-inflammatory molecules in humans. The close links of ORM and measures of adiposity, insulin resistance, and adipose tissue inflammation in humans reinforce previous experimental data and warrant further studies to explore a possible role of ORM in the pathogenesis of obesity-associated metabolic derangements.

Improvement of psychometric properties of the objective structured clinical examination when assessing problem solving skills of surgical clerkship.

OBJECTIVE: To improve the psychometric properties of the objective structured clinical examination (OSCE) and elevate staff motivation. METHODS: The OSCE was conducted in May 2006 at the Department of Surgery, King Saud University, Riyadh, Saudi Arabia as a pilot study for 95 students split over 2 consecutive days lasting 120 minutes each day. There were 15 actual stations on each day consisting of 10 stations that addressed problem solving skills, and 5 addressed clinical skills testing. RESULTS: The stability of the OSCE measured by Cronbach's alpha on day one was 0.87, and 0.88 on day 2. The internal consistency of the OSCE measured by Carmine's theta on day one was 0.76, and 0.79 on day 2. Overall, OSCE's reliability for each day was high (r=0.8), without a significant difference between the 2 days. Credibility and comprehensiveness of the the OSCE were considered good by both staff and students. Accuracy of the OSCE measured by Pearson's correlation with multiple choice question scores was 0.65. Feasibility of the OSCE has also improved remarkably compared with previous OSCEs. CONCLUSION: The OSCE proved to be highly reliable, and a valid format when more problem solving skills testing has been emphasized for the final year surgical clerkship. Feasibility has also improved remarkably after using this strategy, marked by more staff participation and enthusiasm.

Trauma care systems in Saudi Arabia: an agenda for action.

Saudi Arabia is undergoing a rapid population growth that along with improved socioeconomics has led many individuals to own a car or even a number of cars per family, resulting in a greater number of vehicles on the roads. The reduced focus on good public transportation systems and the dependence on cars for transportation have created a diversity of drivers who are unfamiliar with the local driving rules and lack the basic skills for safe driving. This is in addition to some young drivers who frequently violate traffic laws and tend to speed most of the time. This unplanned expansion in road traffic has resulted in more car accidents, injuries, disabilities, and deaths. Accompanying that is an increased socioeconomic burden, depletion of human resources, emotional and psychological stress on families, and a strain on healthcare facilities. If this continues without prompt intervention, it will lead to increased insurance premiums and may become unmanageable. To minimize this impact, a national or regional multidisciplinary trauma system has to be developed and implemented. A trauma system is a preplanned, comprehensive, and coordinated regional injury response network that includes all facilities with the capability to care for the injured. Essential components of the system include trauma prevention, prehospital care, hospital care, rehabilitation, system administration, trauma care education and training, trauma care evaluation and quality improvement, along with the participation of society. Research has documented a significant decrease in morbidity and mortality from trauma after the implementation of such systems, depending on their efficiency. The purpose of this review is to discuss the problem of road traffic accidents in this country and address the trauma care system as an effective solution.

Reliability, validity, and feasibility of the Objective Structured Clinical Examination in assessing clinical skills of final year surgical clerkship.

OBJECTIVE: To report our experience with measurements of the objective structured clinical examination (OSCE) conducted for the final surgical clerkship year. METHODS: A pilot study of the OSCE was conducted on 64 students split over 2 consecutive days lasting 160 minutes each day in May 22-23, 2005 at the Department of Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. There were 24 actual stations in day one and 22 in day 2, consisting of combinations of history taking/communication skills, physical examination skills, and problem solving skills. RESULTS: The stability of the OSCE measured by Cronbach's alpha on day one was 0.68 and 0.79 on day 2. The internal consistency of the OSCE measured by Carmine's theta on day one was 0.79 and 0.81 on day 2. Credibility and comprehensiveness of the OSCE were considered good by both staff and students. Accuracy of the OSCE measured by Pearson;s correlation with the MCQs was 0.5. CONCLUSION: The OSCE proved to be reliable, and a valid format for testing the clinical skills of final surgical clerkship year. Feasibility of the OSCE can be further improved with experience, repetitions, and use of standardized patients.

Clinicopathological pattern of malignant parotid gland tumors in Saudi Arabia.

OBJECTIVE: To report our experience of varied presentations and diverse histopathological spectrum of parotid gland malignancies. METHODS: This retrospective analysis incorporated patients with histological evidence of malignant parotid tumors at King Khalid University Hospital, Riyadh, Saudi Arabia over a 20-year period from 1984 through 2004. The medical records of these patients were analyzed for their demographic characteristics, clinical features, operations performed, and pathological diversity. RESULTS: Thirty-two patients comprised this study group. There is a male preponderance over females with a ratio of 2.2:1 (22 men and 10 women) and mean age of 51.8 (range 28-81 years). A painless lump was the most frequent clinical manifestation observed in 23 (71.8%) patients followed by facial nerve dysfunction in 14 (43.7%) patients. Parotidectomy was performed in 22 (68.7%) patients: 16 superficial and 6 total. A partial facial nerve sacrifice was undertaken in 14 (43.7%), and total nerve sacrifice in 9 (28.1%) patients. Four (12.5%) patients presented with cervical lymph node metastases necessitating radical neck dissection. Nine (28.1%) patients had mucoepidermoid carcinoma, 8 (25%) adenoid cystic carcinoma, 6 (18.7%) adenocarcinoma, not otherwise specified, and 2 (6.2%) were reported to have carcinoma in pleomorphic adenoma. Twenty (62.5%) specimens revealed high-grade aggressive lesions, and out of these, 19 (59.3%) patients presented with stage III/IV disease. CONCLUSION: Malignant parotid tumors are exceedingly rare, occurring at a relatively earlier age group with male preponderance, and invariably declare at a late clinical stage in our community. Histopathological features hallmark a locally advanced disease with an aggressive behavior.

Outpatient pilonidal sinotomy complemented with good wound and surrounding skin care.

OBJECTIVE: To describe an improved method for treating pilonidal sinus disease. METHODS: An outpatient procedure involves laying the pilonidal sinus tract open under local anesthesia, removal of hair and debris, curettage of granulation tissue, with subsequent daily dressing, weekly shaving, and let it heal by secondary intention. The medical records of 100 patients underwent this procedure were studied regarding complications, healing time, and recurrence. This study was carried out at King Abdul-Aziz Medical City, Riyadh, Kingdom of Saudi Arabia, between January 2000 and December 2003. RESULTS: Ninety-five patients (95%) were males and 5 patients (5%) were females. The mean age was 21.7 years. Almost all patients who underwent the procedure were discharged after the procedure. Complications included 2 cases (2%) of bleeding, one case (1%) of vasovagal attack requiring admission overnight, 10 cases (10%) of delayed healing, and 2 cases (2%) of recurrence after an average of one year from complete wound healing. Ninety patients (90%) had completed healing after one month of daily dressing and 10 patients (10%) after 2 months. CONCLUSION: Outpatient pilonidal sinotomy with good wound and surrounding skin care is an ideal approach with high chance of cure.

Quality improvement data analysis of a mass casualty event.

Trauma auditing is important for monitoring the process of trauma care and outcome prediction. This pilot study was conducted to evaluate quality improvement (QI) data following a mass casualty event and discuss its impact on the trauma care process and outcome. A pre-designed trauma quality improvement data set was used for all 103 injured patients admitted to Asir Central Hospital, Saudi Arabia, who were involved in a single motor vehicle crash. Most of the trauma management variations from norms occurred during the initial assessment and resuscitation phase of care, and these had the greatest impact on morbidity and mortality. Trauma management variations throughout all phases of care were associated with 10% and 9% incidence of preventable morbidity and mortality, respectively. Efforts including rigorous educational programs should be made to stress the initial assessment and resuscitation phase of care. Successful regionalized trauma care systems involving quality improvement programs report significant reduction in morbidity and mortality rates from trauma.

The use of laparoscopy to assess viability of slipped content in incarcerated inguinal hernia: a case report.

Incarcerated inguinal hernia classically has been managed by initially attempting gentle reduction or spontaneous reduction with systemic analgesics and slight feet elevation over 24 to 48 hours and, if unsuccessful, by urgent surgical repair. We report a case of incarcerated inguinal hernia in which at open surgical repair the contents of the hernial sac slipped into the abdomen before evaluation. Using laparoscopy, the involved bowel was retrieved into the groin and its viability assessed. We recommend this procedure as an alternative to laparotomy in such situations.