1.
Bioorg Med Chem Lett
; 25(15): 3034-8, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26048791
RESUMO
The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties. Compound 21 demonstrated robust acute and chronic regulatory effects on glycemic parameters in the diabetic or non-diabetic rodent models.