RESUMO
Many factors, including hyperglycemia, hypertension, obesity, dyslipidemia, and a sedentary lifestyle, contribute to a high prevalence of cardiovascular disease. Specific vascular impairment treatments in the context of diabetes and vascular risk need to be improved. Salidroside is the primary active component of Rhodiola rosea and has documented antioxidative, cardioprotective, and vasculoprotective properties. The aim of this study was to test the hypothesis that salidroside has protective effects against hyperglycemia, hypertension, and vasodilation impairment in the Goto-Kakizaki (GK) rat model of diabetes. We evaluated cardiovascular parameters (e.g., daytime/nighttime systolic and diastolic blood pressure, heart rate, and activity), metabolic parameters (e.g., body weight, food and water consumption, serum fructosamine level, glucose tolerance), eNOS / phospho-eNOS expression level and in vitro vascular reactivity of aorta and second-order mesenteric arteries in Wistar-Kyoto (control) and GK (diabetic) rats treated with salidroside (40 mg/kg) or placebo (water) for 5 weeks. GK rats showed hypertension, marked glucose intolerance, and impaired endothelium-dependent and endothelium-independent vasodilation capacity. Salidroside showed beneficial effects on endothelial and non-endothelial vasodilation and likely acts on the endothelium and smooth muscle cells through the soluble guanylyl cyclase pathway. Despite its vascular effects, salidroside had no effect on blood pressure and heart rate in GK and control rats, it did not improve glucose metabolism or limit hypertension in the GK model of type 2 diabetes.
Assuntos
Doenças Cardiovasculares/tratamento farmacológico , Sistema Cardiovascular/efeitos dos fármacos , Diabetes Mellitus Tipo 2/metabolismo , Glucosídeos/farmacologia , Fenóis/farmacologia , Animais , Aorta/efeitos dos fármacos , Aorta/metabolismo , Pressão Sanguínea/efeitos dos fármacos , Cardiotônicos/farmacologia , Doenças Cardiovasculares/metabolismo , Sistema Cardiovascular/metabolismo , Endotélio Vascular/efeitos dos fármacos , Endotélio Vascular/metabolismo , Intolerância à Glucose/metabolismo , Guanilato Ciclase/metabolismo , Frequência Cardíaca/efeitos dos fármacos , Hiperglicemia/tratamento farmacológico , Hiperglicemia/metabolismo , Hipertensão/metabolismo , Masculino , Miócitos de Músculo Liso/efeitos dos fármacos , Miócitos de Músculo Liso/metabolismo , Óxido Nítrico Sintase Tipo III/metabolismo , Ratos , Ratos Endogâmicos WKY , Receptores Citoplasmáticos e Nucleares/metabolismo , Guanilil Ciclase Solúvel , Vasodilatação/efeitos dos fármacosRESUMO
We describe a case of a giant right atrial large B-cell lymphoma treated with initial surgical excision followed by postoperative chemotherapy. The patient had no clinical evidence of recurrence through 87 months after her hospital discharge. To our knowledge, this is the first reported case of long-term survival following this method of disease management. The discussion reviews the current status of chemotherapy for cardiac lymphomas and the pros and cons of treatment option algorithms.
Assuntos
Procedimentos Cirúrgicos Cardíacos/métodos , Neoplasias Cardíacas/cirurgia , Linfoma Difuso de Grandes Células B/cirurgia , Adulto , Ecocardiografia Transesofagiana , Feminino , Seguimentos , Átrios do Coração , Neoplasias Cardíacas/diagnóstico , Humanos , Linfoma Difuso de Grandes Células B/diagnóstico , Tomografia Computadorizada por Raios XRESUMO
Besides quality, the length of the greater saphenous vein dictates the feasibility of vein bypass grafts in femorodistal popliteal or tibial revascularization. A simple and effective technique of lengthening the greater saphenous vein is described that allows the use of the laterofemoral cutaneous vein in continuity. This technique can be applied when the distal segment of the greater saphenous vein is inadequate or unavailable.
Assuntos
Veia Femoral/transplante , Veia Safena/transplante , Idoso , Idoso de 80 Anos ou mais , Estudos de Viabilidade , Feminino , Veia Femoral/anatomia & histologia , Seguimentos , Humanos , Flebite/cirurgia , Veia Poplítea/cirurgia , Veia Safena/anatomia & histologia , Tíbia/irrigação sanguínea , Varizes/cirurgia , Veias/cirurgiaRESUMO
We describe a technique of repairing autologous vein grafts affected by segmental stenosis. This technique can be of value both in reoperating on an old saphenous vein graft implanted for infrainguinal limb revascularization and in harvesting fresh saphenous vein in which an unexpected short-segment stenosis has been encountered.