Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Crit Rev Food Sci Nutr ; 53(11): 1157-67, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24007420

RESUMO

One of the main functions of L-arginine (ARG) is the synthesis of nitric oxide (NO). NO is an important regulator of physiological processes in the central nervous system (CNS). NO promotes optimal cerebral blood flow, consolidates memory processes, facilitates long-term potentiation, maintains sleep-wake cycles, and assists in normal olfaction. However, at pathological levels, NO adversely affects brain function producing nitroxidative stress and promoting development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and other disorders of the CNS. This review summarizes current knowledge of the role of NO in the CNS and the role of diet in regulating the levels of NO.


Assuntos
Arginina/fisiologia , Sistema Nervoso Central/fisiopatologia , Doenças Neurodegenerativas/fisiopatologia , Óxido Nítrico/fisiologia , Doença de Alzheimer/sangue , Doença de Alzheimer/líquido cefalorraquidiano , Doença de Alzheimer/fisiopatologia , Animais , Arginina/sangue , Arginina/líquido cefalorraquidiano , Doenças do Sistema Nervoso Central/fisiopatologia , Dieta , Humanos , Óxido Nítrico/sangue , Óxido Nítrico/líquido cefalorraquidiano , Óxido Nítrico Sintase , Doença de Parkinson/sangue , Doença de Parkinson/líquido cefalorraquidiano , Doença de Parkinson/fisiopatologia
2.
Crit Rev Food Sci Nutr ; 52(11): 980-7, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22823346

RESUMO

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system and characterized by neurological and cognitive manifestations. The disease is more common in populations living in high altitudes with low sun exposure, women more than men, and certain ethnic backgrounds more than others. The etiology of MS is yet unknown, although several factors have been implicated in its development. These include genetic factors and environmental factors as well as dietary components and their interactions. Among the dietary components that have recently attracted the attention is vitamin D. This mini-review summarizes current knowledge on the potential use of vitamin D in the protection and treatment of MS. In addition, the mechanism(s) by which vitamin D plays a role in the development and/or protection from MS are discussed.


Assuntos
Esclerose Múltipla/fisiopatologia , Deficiência de Vitamina D/fisiopatologia , Vitamina D/administração & dosagem , Vitaminas/administração & dosagem , Animais , Linfócitos B/efeitos dos fármacos , Células Dendríticas/efeitos dos fármacos , Dieta , Interação Gene-Ambiente , Predisposição Genética para Doença , Humanos , Esclerose Múltipla/etiologia , Esclerose Múltipla/prevenção & controle , Estado Nutricional , Linfócitos T/efeitos dos fármacos , Deficiência de Vitamina D/complicações
3.
Crit Rev Food Sci Nutr ; 52(2): 103-12, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22059957

RESUMO

The metabolic syndrome develops in an individual with any three of the following risk factors: obesity, diabetes, inflammation, hypertension, dyslipidemia, and thrombosis. Recent evidence suggests that vitamin D may play a role in the development of some of these risk factors. The metabolic syndrome is more common in western societies than the underdeveloped countries. Individuals in western societies usually consume a high calorie diet that lacks essential nutrients and, by virtue of being located in the northern hemisphere, they have limited sun exposures which restrict their vitamin D synthesis. Moreover, the lifestyle of these societies is considered sedentary. These dietary and environmental factors coupled with the sedentary lifestyle predispose them to metabolic syndrome risk factors. Active research revealed the role of vitamin D in the development of obesity, diabetes, inflammation, and hypertension. On the other hand, limited research has been done on the role of vitamin D in other risk factors such as dyslipidemia and thrombosis. The scientific community proposes to increase the current vitamin D fortification level in foods to reduce the risk factors of the metabolic syndrome.


Assuntos
Síndrome Metabólica/sangue , Síndrome Metabólica/complicações , Deficiência de Vitamina D/complicações , Vitamina D/sangue , Humanos , Fatores de Risco
4.
Nutr Rev ; 68(12): 729-38, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21091916

RESUMO

The incidence of obesity is increasing worldwide and is hence considered a major public health concern. Obesity underlies the development of several metabolic complications including cardiovascular diseases, diabetes, and inflammation. Research on ways to slow the development of obesity have traditionally focused on dietary and lifestyle modifications such as restricting caloric intake and increasing physical activity. An area that has recently aroused considerable research interest is investigating the potential role of spices, particularly the Asian spice turmeric, for combating obesity. Curcumin is the active ingredient in turmeric. Evidence suggests curcumin may regulate lipid metabolism, which plays a central role in the development of obesity and its complications. The present review addresses the evidence and mechanisms by which curcumin may play a role in downregulating obesity and reducing the impact of associated problems.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Curcumina/uso terapêutico , Inflamação/prevenção & controle , Metabolismo dos Lipídeos/efeitos dos fármacos , Obesidade/fisiopatologia , Anti-Inflamatórios não Esteroides/administração & dosagem , Antioxidantes/administração & dosagem , Antioxidantes/uso terapêutico , Curcumina/administração & dosagem , Regulação para Baixo , Medicina Baseada em Evidências , Humanos , Obesidade/dietoterapia
5.
Int Immunopharmacol ; 10(11): 1390-6, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20728596

RESUMO

Among the many functions of vitamin D (VD) is its role in the immunomodulation of macrophage. As VD deficiency is a wide-spread nutritional problem, there is a tendency for the public to overdose with vitamin D supplementation which can result in hypercalcemia and several associated disorders. The present study was designed to investigate the possibility that combining low doses of vitamin D with ß-sitosterol (SIT), a common phytosterol in the diet without toxicity, enhances the efficacy of the vitamin. Murine macrophages were stimulated with LPS and supplemented with VD3 (80 nM) and SIT (8 µM) for 24 hr and examined for cell proliferation, release of nitric oxide (NO) and cytokines and the activation of NFκB. SIT (8 µM) was found to reduce cell proliferation by 62% while VD3 was found to be not effective. In combination, SIT and VD3 reduced cell proliferation by 75%.The amount of NO released, as influenced by 8 µM SIT or 80 nM VD3 treatments, was not significantly different from control. Combining SIT and VD3, resulted in a 220% greater increase in NO release compared to control. The SIT + VD3 treatment brought about significant increase in all the cytokine release, regardless of whether they were pro- or anti-inflammatory. The effects were either additive or synergistic. We conclude that SIT enhances the action of VD3 on the immune function of macrophages which could be beneficial to vitamin D deficient individuals and to those with autoimmune diseases such as multiple sclerosis.


Assuntos
Colecalciferol/farmacologia , Fatores Imunológicos/farmacologia , Ativação de Macrófagos/efeitos dos fármacos , Macrófagos/efeitos dos fármacos , Sitosteroides/farmacologia , Vitaminas/farmacologia , Animais , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Citocinas/imunologia , Sinergismo Farmacológico , Lipopolissacarídeos/imunologia , Macrófagos/imunologia , Camundongos , NF-kappa B/imunologia , Óxido Nítrico/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...