[Incidence of immune deficiency in children population from industrial city]. / Rasprostranennost' immunologicheskoi nedostatochnosti sredi detskogo naseleniia promyshlennogo goroda.

The authors relate the data on the incidence of different forms of immune deficiency (ID). The studies were carried out within the framework of the All-Union program of mass immunoepidemiological screenings, among the childhood population of industrial city numbering 59,178 persons. The primary group at ID risk amounting to 2.2% was distinguished. Based on the clinico-anamnestic data a group at higher ID risk was made up (n-421). 450 children were examined by the level I tests. The children were characterized clinicoimmunologically according to different immunopathological syndromes. All the children with the identified forms of ID and those without well-defined forms of immunodeficiency conditions but with steady alterations of the immunologic parameters and the clinical signs need prophylactic medical examinations.

[Mechanism of the suppression of the formation of immunologic memory]. / O mekhanizme supressii formirovaniia immunologicheskoi pamiati.

An extract from splenocytes of mice immunized with sheep red blood cells contains suppressor factor (SF) that specifically inhibits the primary immune response. The system of adoptive transfer was studied for the action of the SF on the formation of immunologic memory for sheep and rat blood cells. It was established that the SF carrying a receptor for specific antigen causes nonspecific suppression of the generation of immunologic memory cells. Within the system in question radioresistant T helper cells act as suppression targets. It is suggested that the final effect of the SF lies in the inhibition of the release of transmitters promoting differentiation or proliferation of T memory cells.

[Nonspecific antigenic suppression of the formation of immunologic memory to heteroerythrocytes]. / Antigennespetsificheskaia supressia formirovaniia immunologicheskoi pamiati k chuzherodnym éritrotsitam.

Spleen cells (SC) of mice immunized with sheep red blood cells contain factor that suppresses primary immune response and the formation of immunologic memory. During studies of antigen-specific suppression of the immunogenesis, it has been discovered that suppressor factor of SC non-specifically blocks the development of immunologic memory for the other antigen (rat red cells) without affecting primary immune response to this antigen administration. It is assumed that at an early stage the cells responsible for the formation of immunologic memory are more sensitive to the non-specific effect of suppressor factor than those involved in the generation of primary immune response.

[Effect of suppressor cells on the formation of immunologic memory in mice of various strains]. / Vliianie kletok supressorov na formirovanie immunologicheskoi pamiati u myshei raznykh linii.

The mice of different lines were immunized twice with low doses (10(6) of sheep red blood cells (SRBC) at a 7-day interval. The immune spleen cells (ISC) from syngeneic and allogeneic mice preliminarily (14 days before) given SRBC (5 . 10(8) were transplanted into the animals at varying times before or after primary antigen administration. It was discovered that the administration of the ISC from CBA and DBA/2 mice to syngeneic mice 1 or 2 days after the priming drastically lowers the production of antibody-forming cells in the recipients in response to the repeated antigen injection. The ISC from C57BL/6 mice provided low suppressor effect. ISC transplantation one, three or six days after the priming exerted no effect on the height of the secondary immune response. Suppression of antibody formation was also obtained in the allogeneic combinations CBA ISC leads to leads to C57BL/6 and DBA/2 ISC leads to CBA. It is concluded that the spleen cells from mice immunized with SRBC are capable to suppress the development of the immunological memory of SRBC.