RESUMO
Copper-based radiopharmaceuticals are of high interest these days owing to the decay properties of copper radioisotopes. In contrast, labeled zinc compounds have been less studied for applications in nuclear medicine. In this study, the stability of labeled zinc and copper complexes with two azacrown ether ligands was investigated and compared. Then, the in vitro and in vivo stability of the studied zinc complexes was demonstrated, with the complexes showing promise for biomedical applications. In contrast, analogous copper complexes quickly dissociated in the presence of serum proteins. Furthermore, a simple method for the production of radiochemically pure 65Zn was proposed, and the opportunity for its use as a surrogate radionuclide for research into potential zinc-containing radiopharmaceuticals was demonstrated.
Assuntos
Complexos de Coordenação/química , Cobre/química , Éteres de Coroa/química , Zinco/química , Animais , Complexos de Coordenação/sangue , Complexos de Coordenação/urina , Cristalografia por Raios X , Ligantes , Espectroscopia de Ressonância Magnética , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Conformação Molecular , Radioisótopos de Zinco/químicaRESUMO
A new benzoazacrown ligand H4BATA was synthesized and its complexation ability towards bismuth cations was evaluated. Binding of cation occurs at room temperature in a few minutes and formed complex exhibits the same level of inertness as highly stable complex with the well-known H4DOTA in biologically relevant and challenging media under in vivo conditions.
