RESUMO
The clinical observation and analysis of the reasons for late diagnosis of congenital heart disease is presented. A feature of this observation is diagnosed complex congenital heart defect with shunting of blood in elderly woman with the second disease--chronic viral hepatitis C and cirrhosis of the liver. Long-term compensation circulation and lack of pulmonary fibrosis in our patient with patent foramen ovale was due to the presence of a second malformation--confluence of the left pulmonary veins in vena cava superior that apparently contributed to the constant lung tissue haemooxygenation.
Assuntos
Forame Oval Patente , Insuficiência Cardíaca , Hepatite C Crônica , Hipertensão Pulmonar , Cirrose Hepática , Veias Pulmonares/anormalidades , Veia Cava Superior/anormalidades , Idoso , Feminino , Forame Oval Patente/complicações , Forame Oval Patente/patologia , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/patologia , Hepatite C Crônica/complicações , Hepatite C Crônica/patologia , Humanos , Hipertensão Pulmonar/complicações , Hipertensão Pulmonar/patologia , Cirrose Hepática/complicações , Cirrose Hepática/patologiaRESUMO
Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17ß-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.
Assuntos
Estradiol/sangue , Ciclo Estral/efeitos dos fármacos , Plastoquinona/análogos & derivados , Animais , Relação Dose-Resposta a Droga , Feminino , Plastoquinona/química , Plastoquinona/farmacologia , Ratos , Ratos WistarRESUMO
The ability of cationic plastoquinone derivative 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) to modify processes of spontaneous and induced mutagenesis was studied. It is shown that daily introduction of this compound into male Wistar rats in doses of 25 and 250 nmol/kg during two weeks decreases spontaneous level of chromosome aberrations in anaphase in the eye cornea from 0.39 +/- 0.09 to 0.13 +/- 0.08 and 0.14 +/- 0.05, respectively. The level of 8-hydroxy-2'-deoxyguanosine in blood serum of the investigated animals decreases from 32.12 +/- 1.55 to 25.90 +/- 2.26 and 25.76 +/- 1.50 ng/ml, respectively. These facts indicate that the decrease in spontaneous clastogenesis is caused by decreased level of DNA damage by endogenous reactive oxygen species. A higher dose of SkQ1 also decreases to control level chromosome aberrations caused by oxygen under pressure of 0.5 MPa for 60 min. It is also shown in experiments with bacterial biosensors that SkQ1 is able to efficiently protect cells against genotoxic effect of UV radiation at 300-400 nm.
Assuntos
Antimutagênicos/farmacologia , Mitocôndrias/efeitos dos fármacos , Plastoquinona/farmacologia , Animais , Masculino , Ratos , Ratos WistarRESUMO
Introduction of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17ß-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamateïiron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg.