FEATURES OF MICROBIOTA IN PSORIATIC DISEASE: FROM SKIN AND GUT PERSPECTIVES (REVIEW).

Psoriatic disease is a chronic inflammatory disease characterized by skin lesions. Psoriasis development has been associated both with genetic and environmental factors. Though skin and gut microbiota has been implicated in number of pathologies including atopic dermatitis, inflammatory bowel disease, Crohn's disease, allergy, and obesity, its role has been poorly studied in psoriatic disease, which incorporates both psoriasis and psoriatic arthritis. This literature review summarizes the most recent and major findings on microbiota features in psoriatic disease. Despite conflicting findings, psoriasis patients were frequently found to have distinct microbial composition in both skin and guts especially in the major bacterial phyla, Firmicutes, Bacteroidetes, and genus Akkermansia. Furthermore, bacterial DNA has been found in psoriatic patients both locally and systemically, and altogether suggesting a crucial role of bacteria in psoriatic disease and future studies in this field.

СLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH ADOLESCENCE ACNE AND ACNE TARDA.

Acne is a chronic recurrent androgen-mediated disease of the pilosebaceous complex with a multifactorial genetically determined development mechanism. Currently, there is a tendency to persistent course of the disease, resistance to therapy forms of acne, late debut and change the clinical picture of acne. This could be due to various factors, such as polycystic ovary syndrome, microadenoma and pituitary adenoma, congenital adrenal hyperplasia, SAHA syndrome, etc. Objective - to study the degree of incidence of hyperprolactinemia in patients with acne and features of the clinical course of juvenile and late acne with a background of hyperprolactinemia. We conducted a case-control study, which included 267 patients with varying disease severity. All patients underwent clinical and dermatological examination and determination of prolactin level. The study found that hyperprolactinemia, associated and nonassociated with adenoma, or pituitary microadenoma, can act as a primary factor in the development of acne, promote the persistence of the disease, as well as change skin manifestations in the form of an increase in the area of skin lesions with a smaller accumulation of sebaceous follicles and low androgen-sensitivity, such as the lower third of the back. Thus, in the diagnosis of acne vulgaris, it is necessary to evaluate the hormonal profile of patients, in particular prolactin, especially in the presence of a persistent course, a late start, resistant to therapy forms.