A non-invasive AI-based system for precise grading of anosmia in COVID-19 using neuroimaging.

COVID-19 (Coronavirus), an acute respiratory disorder, is caused by SARS-CoV-2 (coronavirus severe acute respiratory syndrome). The high prevalence of COVID-19 infection has drawn attention to a frequent illness symptom: olfactory and gustatory dysfunction. The primary purpose of this manuscript is to create a Computer-Assisted Diagnostic (CAD) system to determine whether a COVID-19 patient has normal, mild, or severe anosmia. To achieve this goal, we used fluid-attenuated inversion recovery (FLAIR) Magnetic Resonance Imaging (FLAIR-MRI) and Diffusion Tensor Imaging (DTI) to extract the appearance, morphological, and diffusivity markers from the olfactory nerve. The proposed system begins with the identification of the olfactory nerve, which is performed by a skilled expert or radiologist. It then proceeds to carry out the subsequent primary steps: (i) extract appearance markers (i.e., 1 s t and 2 n d order markers), morphology/shape markers (i.e., spherical harmonics), and diffusivity markers (i.e., Fractional Anisotropy (FA) & Mean Diffusivity (MD)), (ii) apply markers fusion based on the integrated markers, and (iii) determine the decision and corresponding performance metrics based on the most-promising classifier. The current study is unusual in that it ensemble bags the learned and fine-tuned ML classifiers and diagnoses olfactory bulb (OB) anosmia using majority voting. In the 5-fold approach, it achieved an accuracy of 94.1%, a balanced accuracy (BAC) of 92.18%, precision of 91.6%, recall of 90.61%, specificity of 93.75%, F1 score of 89.82%, and Intersection over Union (IoU) of 82.62%. In the 10-fold approach, stacking continued to demonstrate impressive results with an accuracy of 94.43%, BAC of 93.0%, precision of 92.03%, recall of 91.39%, specificity of 94.61%, F1 score of 91.23%, and IoU of 84.56%. In the leave-one-subject-out (LOSO) approach, the model continues to exhibit notable outcomes, achieving an accuracy of 91.6%, BAC of 90.27%, precision of 88.55%, recall of 87.96%, specificity of 92.59%, F1 score of 87.94%, and IoU of 78.69%. These results indicate that stacking and majority voting are crucial components of the CAD system, contributing significantly to the overall performance improvements. The proposed technology can help doctors assess which patients need more intensive clinical care.

Prostate Cancer Diagnosis via Visual Representation of Tabular Data and Deep Transfer Learning.

Prostate cancer (PC) is a prevalent and potentially fatal form of cancer that affects men globally. However, the existing diagnostic methods, such as biopsies or digital rectal examination (DRE), have limitations in terms of invasiveness, cost, and accuracy. This study proposes a novel machine learning approach for the diagnosis of PC by leveraging clinical biomarkers and personalized questionnaires. In our research, we explore various machine learning methods, including traditional, tree-based, and advanced tabular deep learning methods, to analyze tabular data related to PC. Additionally, we introduce the novel utilization of convolutional neural networks (CNNs) and transfer learning, which have been predominantly applied in image-related tasks, for handling tabular data after being transformed to proper graphical representations via our proposed Tab2Visual modeling framework. Furthermore, we investigate leveraging the prediction accuracy further by constructing ensemble models. An experimental evaluation of our proposed approach demonstrates its effectiveness in achieving superior performance attaining an F1-score of 0.907 and an AUC of 0.911. This offers promising potential for the accurate detection of PC without the reliance on invasive and high-cost procedures.

Advanced OCTA imaging segmentation: Unsupervised, non-linear retinal vessel detection using modified self-organizing maps and joint MGRF modeling.

BACKGROUND AND OBJECTIVE: This paper proposes a fully automated and unsupervised stochastic segmentation approach using two-level joint Markov-Gibbs Random Field (MGRF) to detect the vascular system from retinal Optical Coherence Tomography Angiography (OCTA) images, which is a critical step in developing Computer-Aided Diagnosis (CAD) systems for detecting retinal diseases. METHODS: Using a new probabilistic model based on a Linear Combination of Discrete Gaussian (LCDG), the first level models the appearance of OCTA images and their spatially smoothed images. The parameters of the LCDG model are estimated using a modified Expectation Maximization (EM) algorithm. The second level models the maps of OCTA images, including the vascular system and other retina tissues, using MGRF with analytically estimated parameters from the input images. The proposed segmentation approach employs modified self-organizing maps as a MAP-based optimizer maximizing the joint likelihood and handles the Joint MGRF model in a new, unsupervised way. This approach deviates from traditional stochastic optimization approaches and leverages non-linear optimization to achieve more accurate segmentation results. RESULTS: The proposed segmentation framework is evaluated quantitatively on a dataset of 204 subjects. Achieving 0.92 ± 0.03 Dice similarity coefficient, 0.69 ± 0.25 95-percentile bidirectional Hausdorff distance, and 0.93 ± 0.03 accuracy, confirms the superior performance of the proposed approach. CONCLUSIONS: The conclusions drawn from the study highlight the superior performance of the proposed unsupervised and fully automated segmentation approach in detecting the vascular system from OCTA images. This approach not only deviates from traditional methods but also achieves more accurate segmentation results, demonstrating its potential in aiding the development of CAD systems for detecting retinal diseases.

Precise Prostate Cancer Assessment Using IVIM-Based Parametric Estimation of Blood Diffusion from DW-MRI.

Prostate cancer is a significant health concern with high mortality rates and substantial economic impact. Early detection plays a crucial role in improving patient outcomes. This study introduces a non-invasive computer-aided diagnosis (CAD) system that leverages intravoxel incoherent motion (IVIM) parameters for the detection and diagnosis of prostate cancer (PCa). IVIM imaging enables the differentiation of water molecule diffusion within capillaries and outside vessels, offering valuable insights into tumor characteristics. The proposed approach utilizes a two-step segmentation approach through the use of three U-Net architectures for extracting tumor-containing regions of interest (ROIs) from the segmented images. The performance of the CAD system is thoroughly evaluated, considering the optimal classifier and IVIM parameters for differentiation and comparing the diagnostic value of IVIM parameters with the commonly used apparent diffusion coefficient (ADC). The results demonstrate that the combination of central zone (CZ) and peripheral zone (PZ) features with the Random Forest Classifier (RFC) yields the best performance. The CAD system achieves an accuracy of 84.08% and a balanced accuracy of 82.60%. This combination showcases high sensitivity (93.24%) and reasonable specificity (71.96%), along with good precision (81.48%) and F1 score (86.96%). These findings highlight the effectiveness of the proposed CAD system in accurately segmenting and diagnosing PCa. This study represents a significant advancement in non-invasive methods for early detection and diagnosis of PCa, showcasing the potential of IVIM parameters in combination with machine learning techniques. This developed solution has the potential to revolutionize PCa diagnosis, leading to improved patient outcomes and reduced healthcare costs.

Transformer-based framework for multi-class segmentation of skin cancer from histopathology images.

Introduction: Non-melanoma skin cancer comprising Basal cell carcinoma (BCC), Squamous cell carcinoma (SCC), and Intraepidermal carcinoma (IEC) has the highest incidence rate among skin cancers. Intelligent decision support systems may address the issue of the limited number of subject experts and help in mitigating the parity of health services between urban centers and remote areas. Method: In this research, we propose a transformer-based model for the segmentation of histopathology images not only into inflammation and cancers such as BCC, SCC, and IEC but also to identify skin tissues and boundaries that are important in decision-making. Accurate segmentation of these tissue types will eventually lead to accurate detection and classification of non-melanoma skin cancer. The segmentation according to tissue types and their visual representation before classification enhances the trust of pathologists and doctors being relatable to how most pathologists approach this problem. The visualization of the confidence of the model in its prediction through uncertainty maps is also what distinguishes this study from most deep learning methods. Results: The evaluation of proposed system is carried out using publicly available dataset. The application of our proposed segmentation system demonstrated good performance with an F1 score of 0.908, mean intersection over union (mIoU) of 0.653, and average accuracy of 83.1%, advocating that the system can be used as a decision support system successfully and has the potential of subsequently maturing into a fully automated system. Discussion: This study is an attempt to automate the segmentation of the most occurring non-melanoma skin cancer using a transformer-based deep learning technique applied to histopathology skin images. Highly accurate segmentation and visual representation of histopathology images according to tissue types by the proposed system implies that the system can be used for skin-related routine pathology tasks including cancer and other anomaly detection, their classification, and measurement of surgical margins in the case of cancer cases.

An AI-based novel system for predicting respiratory support in COVID-19 patients through CT imaging analysis.

The proposed AI-based diagnostic system aims to predict the respiratory support required for COVID-19 patients by analyzing the correlation between COVID-19 lesions and the level of respiratory support provided to the patients. Computed tomography (CT) imaging will be used to analyze the three levels of respiratory support received by the patient: Level 0 (minimum support), Level 1 (non-invasive support such as soft oxygen), and Level 2 (invasive support such as mechanical ventilation). The system will begin by segmenting the COVID-19 lesions from the CT images and creating an appearance model for each lesion using a 2D, rotation-invariant, Markov-Gibbs random field (MGRF) model. Three MGRF-based models will be created, one for each level of respiratory support. This suggests that the system will be able to differentiate between different levels of severity in COVID-19 patients. The system will decide for each patient using a neural network-based fusion system, which combines the estimates of the Gibbs energy from the three MGRF-based models. The proposed system were assessed using 307 COVID-19-infected patients, achieving an accuracy of [Formula: see text], a sensitivity of [Formula: see text], and a specificity of [Formula: see text], indicating a high level of prediction accuracy.

A concentrated machine learning-based classification system for age-related macular degeneration (AMD) diagnosis using fundus images.

The increase in eye disorders among older individuals has raised concerns, necessitating early detection through regular eye examinations. Age-related macular degeneration (AMD), a prevalent condition in individuals over 45, is a leading cause of vision impairment in the elderly. This paper presents a comprehensive computer-aided diagnosis (CAD) framework to categorize fundus images into geographic atrophy (GA), intermediate AMD, normal, and wet AMD categories. This is crucial for early detection and precise diagnosis of age-related macular degeneration (AMD), enabling timely intervention and personalized treatment strategies. We have developed a novel system that extracts both local and global appearance markers from fundus images. These markers are obtained from the entire retina and iso-regions aligned with the optical disc. Applying weighted majority voting on the best classifiers improves performance, resulting in an accuracy of 96.85%, sensitivity of 93.72%, specificity of 97.89%, precision of 93.86%, F1 of 93.72%, ROC of 95.85%, balanced accuracy of 95.81%, and weighted sum of 95.38%. This system not only achieves high accuracy but also provides a detailed assessment of the severity of each retinal region. This approach ensures that the final diagnosis aligns with the physician's understanding of AMD, aiding them in ongoing treatment and follow-up for AMD patients.

A convolutional neural network-based decision support system for neonatal quiet sleep detection.

Sleep plays an important role in neonatal brain and physical development, making its detection and characterization important for assessing early-stage development. In this study, we propose an automatic and computationally efficient algorithm to detect neonatal quiet sleep (QS) using a convolutional neural network (CNN). Our study used 38-hours of electroencephalography (EEG) recordings, collected from 19 neonates at Fudan Children's Hospital in Shanghai, China (Approval No. (2020) 22). To train and test the CNN, we extracted 12 prominent time and frequency domain features from 9 bipolar EEG channels. The CNN architecture comprised two convolutional layers with pooling and rectified linear unit (ReLU) activation. Additionally, a smoothing filter was applied to hold the sleep stage for 3 minutes. Through performance testing, our proposed method achieved impressive results, with 94.07% accuracy, 89.70% sensitivity, 94.40% specificity, 79.82% F1-score and a 0.74 kappa coefficient when compared to human expert annotations. A notable advantage of our approach is its computational efficiency, with the entire training and testing process requiring only 7.97 seconds. The proposed algorithm has been validated using leave one subject out (LOSO) validation, which demonstrates its consistent performance across a diverse range of neonates. Our findings highlight the potential of our algorithm for real-time neonatal sleep stage classification, offering a fast and cost-effective solution. This research opens avenues for further investigations in early-stage development monitoring and the assessment of neonatal health.

A Kullback-Liebler divergence-based representation algorithm for malware detection.

Background: Malware, malicious software, is the major security concern of the digital realm. Conventional cyber-security solutions are challenged by sophisticated malicious behaviors. Currently, an overlap between malicious and legitimate behaviors causes more difficulties in characterizing those behaviors as malicious or legitimate activities. For instance, evasive malware often mimics legitimate behaviors, and evasion techniques are utilized by legitimate and malicious software. Problem: Most of the existing solutions use the traditional term of frequency-inverse document frequency (TF-IDF) technique or its concept to represent malware behaviors. However, the traditional TF-IDF and the developed techniques represent the features, especially the shared ones, inaccurately because those techniques calculate a weight for each feature without considering its distribution in each class; instead, the generated weight is generated based on the distribution of the feature among all the documents. Such presumption can reduce the meaning of those features, and when those features are used to classify malware, they lead to a high false alarms. Method: This study proposes a Kullback-Liebler Divergence-based Term Frequency-Probability Class Distribution (KLD-based TF-PCD) algorithm to represent the extracted features based on the differences between the probability distributions of the terms in malware and benign classes. Unlike the existing solution, the proposed algorithm increases the weights of the important features by using the Kullback-Liebler Divergence tool to measure the differences between their probability distributions in malware and benign classes. Results: The experimental results show that the proposed KLD-based TF-PCD algorithm achieved an accuracy of 0.972, the false positive rate of 0.037, and the F-measure of 0.978. Such results were significant compared to the related work studies. Thus, the proposed KLD-based TF-PCD algorithm contributes to improving the security of cyberspace. Conclusion: New meaningful characteristics have been added by the proposed algorithm to promote the learned knowledge of the classifiers, and thus increase their ability to classify malicious behaviors accurately.

Visual Intelligence in Precision Agriculture: Exploring Plant Disease Detection via Efficient Vision Transformers.

In order for a country's economy to grow, agricultural development is essential. Plant diseases, however, severely hamper crop growth rate and quality. In the absence of domain experts and with low contrast information, accurate identification of these diseases is very challenging and time-consuming. This leads to an agricultural management system in need of a method for automatically detecting disease at an early stage. As a consequence of dimensionality reduction, CNN-based models use pooling layers, which results in the loss of vital information, including the precise location of the most prominent features. In response to these challenges, we propose a fine-tuned technique, GreenViT, for detecting plant infections and diseases based on Vision Transformers (ViTs). Similar to word embedding, we divide the input image into smaller blocks or patches and feed these to the ViT sequentially. Our approach leverages the strengths of ViTs in order to overcome the problems associated with CNN-based models. Experiments on widely used benchmark datasets were conducted to evaluate the proposed GreenViT performance. Based on the obtained experimental outcomes, the proposed technique outperforms state-of-the-art (SOTA) CNN models for detecting plant diseases.

Proliferative Diabetic Retinopathy Diagnosis Using Varying-Scales Filter Banks and Double-Layered Thresholding.

Diabetic retinopathy is one of the abnormalities of the retina in which a diabetic patient suffers from severe vision loss due to an affected retina. Proliferative diabetic retinopathy (PDR) is the final and most critical stage of diabetic retinopathy. Abnormal and fragile blood vessels start to grow on the surface of the retina at this stage. It causes retinal detachment, which may lead to complete blindness in severe cases. In this paper, a novel method is proposed for the detection and grading of neovascularization. The proposed system first performs pre-processing on input retinal images to enhance the vascular pattern, followed by blood vessel segmentation and optic disc localization. Then various features are tested on the candidate regions with different thresholds. In this way, positive and negative advanced diabetic retinopathy cases are separated. Optic disc coordinates are applied for the grading of neovascularization as NVD or NVE. The proposed algorithm improves the quality of automated diagnostic systems by eliminating normal blood vessels and exudates that might cause hindrances in accurate disease detection, thus resulting in more accurate detection of abnormal blood vessels. The evaluation of the proposed system has been carried out using performance parameters such as sensitivity, specificity, accuracy, and positive predictive value (PPV) on a publicly available standard retinal image database and one of the locally available databases. The proposed algorithm gives an accuracy of 98.5% and PPV of 99.8% on MESSIDOR and an accuracy of 96.5% and PPV of 100% on the local database.

Kidney Segmentation from Dynamic Contrast-Enhanced Magnetic Resonance Imaging Integrating Deep Convolutional Neural Networks and Level Set Methods.

The dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technique has taken on a significant and increasing role in diagnostic procedures and treatments for patients who suffer from chronic kidney disease. Careful segmentation of kidneys from DCE-MRI scans is an essential early step towards the evaluation of kidney function. Recently, deep convolutional neural networks have increased in popularity in medical image segmentation. To this end, in this paper, we propose a new and fully automated two-phase approach that integrates convolutional neural networks and level set methods to delimit kidneys in DCE-MRI scans. We first develop two convolutional neural networks that rely on the U-Net structure (UNT) to predict a kidney probability map for DCE-MRI scans. Then, to leverage the segmentation performance, the pixel-wise kidney probability map predicted from the deep model is exploited with the shape prior information in a level set method to guide the contour evolution towards the target kidney. Real DCE-MRI datasets of 45 subjects are used for training, validating, and testing the proposed approach. The valuation results demonstrate the high performance of the two-phase approach, achieving a Dice similarity coefficient of 0.95 ± 0.02 and intersection over union of 0.91 ± 0.03, and 1.54 ± 1.6 considering a 95% Hausdorff distance. Our intensive experiments confirm the potential and effectiveness of that approach over both UNT models and numerous recent level set-based methods.

Scale-adaptive model for detection and grading of age-related macular degeneration from color retinal fundus images.

Age-related Macular Degeneration (AMD), a retinal disease that affects the macula, can be caused by aging abnormalities in number of different cells and tissues in the retina, retinal pigment epithelium, and choroid, leading to vision loss. An advanced form of AMD, called exudative or wet AMD, is characterized by the ingrowth of abnormal blood vessels beneath or into the macula itself. The diagnosis is confirmed by either fundus auto-fluorescence imaging or optical coherence tomography (OCT) supplemented by fluorescein angiography or OCT angiography without dye. Fluorescein angiography, the gold standard diagnostic procedure for AMD, involves invasive injections of fluorescent dye to highlight retinal vasculature. Meanwhile, patients can be exposed to life-threatening allergic reactions and other risks. This study proposes a scale-adaptive auto-encoder-based model integrated with a deep learning model that can detect AMD early by automatically analyzing the texture patterns in color fundus imaging and correlating them to the vasculature activity in the retina. Moreover, the proposed model can automatically distinguish between AMD grades assisting in early diagnosis and thus allowing for earlier treatment of the patient's condition, slowing the disease and minimizing its severity. Our model features two main blocks, the first is an auto-encoder-based network for scale adaption, and the second is a convolutional neural network (CNN) classification network. Based on a conducted set of experiments, the proposed model achieves higher diagnostic accuracy compared to other models with accuracy, sensitivity, and specificity that reach 96.2%, 96.2%, and 99%, respectively.

Using Mean Arterial Pressure in Hypertension Diagnosis versus Using Either Systolic or Diastolic Blood Pressure Measurements.

Hypertension is a severe and highly prevalent disease. It is considered a leading contributor to mortality worldwide. Diagnosis guidelines for hypertension use systolic and diastolic blood pressure (BP) together. Mean arterial pressure (MAP), which refers to the average of the arterial blood pressure through a single cardiac cycle, can be an alternative index that may capture the overall exposure of the person to a heightened pressure. A clinical hypothesis, however, suggests that in patients over 50 years old in age, systolic BP may be more predictive of adverse events, while in patients under 50 years old, diastolic BP may be slightly more predictive. In this study, we investigated the correlation between cerebrovascular changes, (impacted by hypertension), and MAP, systolic BP, and diastolic BP separately. Several experiments were conducted using real and synthetic magnetic resonance angiography (MRA) data, along with corresponding BP measurements. Each experiment employs the following methodology: First, MRA data were processed to remove noise, bias, or inhomogeneity. Second, the cerebrovasculature was delineated for MRA subjects using a 3D adaptive region growing connected components algorithm. Third, vascular features (changes in blood vessel's diameters and tortuosity) that describe cerebrovascular alterations that occur prior to and during the development of hypertension were extracted. Finally, feature vectors were constructed, and data were classified using different classifiers, such as SVM, KNN, linear discriminant, and logistic regression, into either normotensives or hypertensives according to the cerebral vascular alterations and the BP measurements. The initial results showed that MAP would be more beneficial and accurate in identifying the cerebrovascular impact of hypertension (accuracy up to 95.2%) than just using either systolic BP (accuracy up to 89.3%) or diastolic BP (accuracy up to 88.9%). This result emphasizes the pathophysiological significance of MAP and supports prior views that this simple measure may be a superior index for the definition of hypertension and research on hypertension.

A Deep Learning Based Approach for Grading of Diabetic Retinopathy Using Large Fundus Image Dataset.

Diabetic Retinopathy affects one-third of all diabetic patients and may cause vision impairment. It has four stages of progression, i.e., mild non-proliferative, moderate non-proliferative, severe non-proliferative and proliferative Diabetic Retinopathy. The disease has no noticeable symptoms at early stages and may lead to chronic destruction, thus causing permanent blindness if not detected at an early stage. The proposed research provides deep learning frameworks for autonomous detection of Diabetic Retinopathy at an early stage using fundus images. The first framework consists of cascaded neural networks, spanned in three layers where each layer classifies data into two classes, one is the desired stage and the other output is passed to another classifier until the input image is classified as one of the stages. The second framework takes normalized, HSV and RGB fundus images as input to three Convolutional Neural Networks, and the resultant probabilistic vectors are averaged together to obtain the final output of the input image. Third framework used the Long Short Term Memory Module in CNN to emphasize the network in remembering information over a long time span. Proposed frameworks were tested and compared on the large-scale Kaggle fundus image dataset EYEPAC. The evaluations have shown that the second framework outperformed others and achieved an accuracy of 78.06% and 83.78% without and with augmentation, respectively.

Multi-Stage Classification-Based Deep Learning for Gleason System Grading Using Histopathological Images.

In this work, we introduced an automated diagnostic system for Gleason system grading and grade groups (GG) classification using whole slide images (WSIs) of digitized prostate biopsy specimens (PBSs). Our system first classifies the Gleason pattern (GP) from PBSs and then identifies the Gleason score (GS) and GG. We developed a comprehensive DL-based approach to develop a grading pipeline system for the digitized PBSs and consider GP as a classification problem (not segmentation) compared to current research studies (deals with as a segmentation problem). A multilevel binary classification was implemented to enhance the segmentation accuracy for GP. Also, we created three levels of analysis (pyramidal levels) to extract different types of features. Each level has four shallow binary CNN to classify five GP labels. A majority fusion is applied for each pixel that has a total of 39 labeled images to create the final output for GP. The proposed framework is trained, validated, and tested on 3080 WSIs of PBS. The overall diagnostic accuracy for each CNN is evaluated using several metrics: precision (PR), recall (RE), and accuracy, which are documented by the confusion matrices.The results proved our system's potential for classifying all five GP and, thus, GG. The overall accuracy for the GG is evaluated using two metrics, PR and RE. The grade GG results are between 50% to 92% for RE and 50% to 92% for PR. Also, a comparison between our CNN architecture and the standard CNN (ResNet50) highlights our system's advantage. Finally, our deep-learning system achieved an agreement with the consensus grade groups.

A novel hybrid meta-heuristic contrast stretching technique for improved skin lesion segmentation.

The high precedence of epidemiological examination of skin lesions necessitated the well-performing efficient classification and segmentation models. In the past two decades, various algorithms, especially machine/deep learning-based methods, replicated the classical visual examination to accomplish the above-mentioned tasks. These automated streams of models demand evident lesions with less background and noise affecting the region of interest. However, even after the proposal of these advanced techniques, there are gaps in achieving the efficacy of matter. Recently, many preprocessors proposed to enhance the contrast of lesions, which further aided the skin lesion segmentation and classification tasks. Metaheuristics are the methods used to support the search space optimisation problems. We propose a novel Hybrid Metaheuristic Differential Evolution-Bat Algorithm (DE-BA), which estimates parameters used in the brightness preserving contrast stretching transformation function. For extensive experimentation we tested our proposed algorithm on various publicly available databases like ISIC 2016, 2017, 2018 and PH2, and validated the proposed model with some state-of-the-art already existing segmentation models. The tabular and visual comparison of the results concluded that DE-BA as a preprocessor positively enhances the segmentation results.

A Novel System for Precise Grading of Glioma.

Gliomas are the most common type of primary brain tumors and one of the highest causes of mortality worldwide. Accurate grading of gliomas is of immense importance to administer proper treatment plans. In this paper, we develop a comprehensive non-invasive multimodal magnetic resonance (MR)-based computer-aided diagnostic (CAD) system to precisely differentiate between different grades of gliomas (Grades: I, II, III, and IV). A total of 99 patients with gliomas (M = 49, F = 50, age range = 1-79 years) were included after providing their informed consent to participate in this study. The proposed imaging-based glioma grading (GG-CAD) system utilizes three different MR imaging modalities, namely; contrast-enhanced T1-MR, T2-MR known as fluid-attenuated inversion-recovery (FLAIR), and diffusion-weighted (DW-MR) to extract the following imaging features: (i) morphological features based on constructing the histogram of oriented gradients (HOG) and estimating the glioma volume, (ii) first and second orders textural features by constructing histogram, gray-level run length matrix (GLRLM), and gray-level co-occurrence matrix (GLCM), (iii) functional features by estimating voxel-wise apparent diffusion coefficients (ADC) and contrast-enhancement slope. These features are then integrated together and processed using a Gini impurity-based selection approach to find the optimal set of significant features. The reduced significant features are then fed to a multi-layer perceptron artificial neural networks (MLP-ANN) classification model to obtain the final diagnosis of a glioma tumor as Grade I, II, III, or IV. The GG-CAD system was evaluated on the enrolled 99 gliomas (Grade I = 13, Grade II = 22, Grade III = 22, and Grade IV = 42) using a leave-one-subject-out (LOSO) and k-fold stratified (with k = 5 and 10) cross-validation approach. The GG-CAD achieved 0.96 ± 0.02 quadratic-weighted Cohen's kappa and 95.8% ± 1.9% overall diagnostic accuracy at LOSO and an outstanding diagnostic performance at k = 10 and 5. Alternative classifiers, including RFs and SVMlin produced inferior results compared to the proposed MLP-ANN GG-CAD system. These findings demonstrate the feasibility of the proposed CAD system as a novel tool to objectively characterize gliomas using the comprehensive extracted and selected imaging features. The developed GG-CAD system holds promise to be used as a non-invasive diagnostic tool for Precise Grading of Glioma.

Predicting the Level of Respiratory Support in COVID-19 Patients Using Machine Learning.

In this paper, a machine learning-based system for the prediction of the required level of respiratory support in COVID-19 patients is proposed. The level of respiratory support is divided into three classes: class 0 which refers to minimal support, class 1 which refers to non-invasive support, and class 2 which refers to invasive support. A two-stage classification system is built. First, the classification between class 0 and others is performed. Then, the classification between class 1 and class 2 is performed. The system is built using a dataset collected retrospectively from 3491 patients admitted to tertiary care hospitals at the University of Louisville Medical Center. The use of the feature selection method based on analysis of variance is demonstrated in the paper. Furthermore, a dimensionality reduction method called principal component analysis is used. XGBoost classifier achieves the best classification accuracy (84%) in the first stage. It also achieved optimal performance in the second stage, with a classification accuracy of 83%.

A Fuzzy-Based Context-Aware Misbehavior Detecting Scheme for Detecting Rogue Nodes in Vehicular Ad Hoc Network.

A vehicular ad hoc network (VANET) is an emerging technology that improves road safety, traffic efficiency, and passenger comfort. VANETs' applications rely on co-operativeness among vehicles by periodically sharing their context information, such as position speed and acceleration, among others, at a high rate due to high vehicles mobility. However, rogue nodes, which exploit the co-operativeness feature and share false messages, can disrupt the fundamental operations of any potential application and cause the loss of people's lives and properties. Unfortunately, most of the current solutions cannot effectively detect rogue nodes due to the continuous context change and the inconsideration of dynamic data uncertainty during the identification. Although there are few context-aware solutions proposed for VANET, most of these solutions are data-centric. A vehicle is considered malicious if it shares false or inaccurate messages. Such a rule is fuzzy and not consistently accurate due to the dynamic uncertainty of the vehicular context, which leads to a poor detection rate. To this end, this study proposed a fuzzy-based context-aware detection model to improve the overall detection performance. A fuzzy inference system is constructed to evaluate the vehicles based on their generated information. The output of the proposed fuzzy inference system is used to build a dynamic context reference based on the proposed fuzzy inference system. Vehicles are classified into either honest or rogue nodes based on the deviation of their evaluation scores calculated using the proposed fuzzy inference system from the context reference. Extensive experiments were carried out to evaluate the proposed model. Results show that the proposed model outperforms the state-of-the-art models. It achieves a 7.88% improvement in the overall performance, while a 16.46% improvement is attained for detection rate compared to the state-of-the-art model. The proposed model can be used to evict the rogue nodes, and thus improve the safety and traffic efficiency of crewed or uncrewed vehicles designed for different environments, land, naval, or air.