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1.
Sci Rep ; 14(1): 10588, 2024 05 08.
Artigo em Inglês | MEDLINE | ID: mdl-38719919

RESUMO

Solitary wave solutions are of great interest to bio-mathematicians and other scientists because they provide a basic description of nonlinear phenomena with many practical applications. They provide a strong foundation for the development of novel biological and medical models and therapies because of their remarkable behavior and persistence. They have the potential to improve our comprehension of intricate biological systems and help us create novel therapeutic approaches, which is something that researchers are actively investigating. In this study, solitary wave solutions of the nonlinear Murray equation will be discovered using a modified extended direct algebraic method. These solutions represent a uniform variation in blood vessel shape and diameter that can be used to stimulate blood flow in patients with cardiovascular disease. These solutions are newly in the literature, and give researchers an important tool for grasping complex biological systems. To see how the solitary wave solutions behave, graphs are displayed using Matlab.


Assuntos
Dinâmica não Linear , Humanos , Modelos Cardiovasculares , Vasos Sanguíneos/fisiologia , Velocidade do Fluxo Sanguíneo , Algoritmos
2.
Sci Rep ; 13(1): 21993, 2023 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-38081842

RESUMO

Salmonella Typhi, a bacteria, is responsible for typhoid fever, a potentially dangerous infection. Typhoid fever affects a large number of people each year, estimated to be between 11 and 20 million, resulting in a high mortality rate of 128,000 to 161,000 deaths. This research investigates a robust numerical analytic strategy for typhoid fever that takes infection protection into consideration and incorporates fuzzy parameters. The use of fuzzy parameters acknowledges the variation in parameter values among individuals in the population, which leads to uncertainties. Because of their diverse histories, different age groups within this community may exhibit distinct customs, habits, and levels of resistance. Fuzzy theory appears as the most appropriate instrument for dealing with these uncertainty. With this in mind, a model of typhoid fever featuring fuzzy parameters is thoroughly examined. Two numerical techniques are developed within a fuzzy framework to address this model. We employ the non-standard finite difference (NSFD) scheme, which ensures the preservation of essential properties like dynamic consistency and positivity. Additionally, we conduct numerical simulations to illustrate the practical applicability of the developed technique. In contrast to many classical methods commonly found in the literature, the proposed approach exhibits unconditional convergence, solidifying its status as a dependable tool for investigating the dynamics of typhoid disease.


Assuntos
Febre Tifoide , Humanos , Febre Tifoide/microbiologia , Salmonella typhi
3.
Comput Intell Neurosci ; 2022: 9957514, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36188674

RESUMO

Game theory is an excellent mathematical tool to describe the interaction between the immune system and cancerous leukocytes (c.leu). The feature of cancerous leukocytes to differentiate and mutate to give rise to leukemia is in the domain of ecological models as well. In this work, the dynamic of leukemia is described and compared by two models: firstly by a simple probabilistic mathematical model using the zero-sum two player game of Hawk and Dove, and secondly by Leslie Predator Prey model of ecology. The main goal of this study is to compare the results of both models and then discuss the treatment of leukemia i.e., Hematopoietic Stem cell transplant with the best model among them. Hawk and Dove model also describes the cell to cell interaction of cancerous leukocytes and healthy leukocytes (leu) after diagnoses and the condition of the patient before and after treatments. In this work, Hematopoietic Stem cell transplant is discussed by using concepts of a zero-sum three player game. Also, both models will be characterized by determining the stability properties, identifying basins of attraction, and locating the equilibrium points to see, at what extent the patient's survival is possible with leukemia in its body. Results for both models will be presented graphically.


Assuntos
Teoria dos Jogos , Leucemia , Ecologia , Humanos , Leucemia/terapia , Modelos Biológicos , Modelos Teóricos
4.
Math Biosci Eng ; 19(9): 9357-9370, 2022 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-35942763

RESUMO

During the past few years, freelancing has grown exponentially due to the pandemic and subsequent economical changes in the world. In fact, in the last ten years, a drastic increase in freelancing has been observed; people quit their jobs to be their own boss. There are various reasons for this: downsizing of employees, not having fun in their jobs, unemployment, part time work to earn more, etc. Observing this vast change, many individuals on Facebook/YouTube, NGOs, and government departments started teaching freelancing as a course; to date, thousands of youngsters have been trained to start their careers as freelancers. It has been observed that the ratio of informed freelancers is more successful than those who start their careers independently. We construct a compartmental model to explore the influence of information on the expansion of freelancing in this article, which was motivated by this surge in freelancing. Following that, the model is subjected to dynamical analysis utilizing dynamical systems and differential equation theory. To validate our analytical conclusions, we used numerical simulation.

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