[Comparative evaluation of the antihypertensive efficacy of amlodipine versus enalapril]. / Uporedna analiza antihipertenzivnog efekta amlodipina i enalaprila.

Goal of this study was to compare the efficacy and safety of amlodipine with enalaprile in case of patients with moderate essential arterial hypertension. Study involved 40 patients with hypertension, 22 males and 18 females, age 39-80 years. Diastolic blood pressure was from 100-120 mmHg. Patients were for two weeks without any therapy and after that were divided into two groups of 20, fortherapy with amlodipine or enalaprile. The patients received 5-10 mg of amlodipine or enalaprile once daily. Initial blood pressure, before therapy was similar in groups, 173.00/108.00 mmHg and 175.25/106.75 mmHg (mean value). After four weeks on treatment the BP was reduced in both groups, in group on amlodipine from 173.00/108.00 to 129.75/78.50 mmHg (mean value), and in the group on enalaprile from 175.25/106.75 to 133.50/81.50 mmHg. Patients did not report any side effects in either of the groups. We prove that one day therapy with small doses, 5-10 mg of amlodipine, new calcium channels blocker and enalaprile, ACE inhibitor were efficient and safe in therapy of the essential hypertension. We found that amlodipine was somewhat more efficient than enalaprile in lowering the blood pressure.

Epidemiology features of brucellosis at the Zenica-Doboj Canton area in period 2000-2007.

Area of Zenica Doboj Canton (ZDC), as well as other areas in Bosnia and Herzegovina, due to geographic, climate and agricultural features, also because of the fact, that animal farms and human habitats are closely related, as well as due to the poor hygiene conditions in places with dominant sheep farming, have fruitful conditions for endemic persistence and spreading of brucellosis, as a typical zoonosis. Lack of systematic research about farms that keeping the animals, and Program of control and suppression of brucellosis, as well as other veterinary measures in order to control the health of domestic animals, in order to protect the health of the human population, have the consequence in continuous presence of brucellosis among animals and humans in this area. As the confirmation of this is also the data about the frequency of this disease in the period 2000-2007, is analyzed in this paper. Follow up and control of brucellosis within human population in ZDC during the period observed showed continuous presence of brucellosis with changing morbidity rate and with the tendency for increasing in this period. During observed time period also noticed was the epidemic occurrence of this disease in two municipalities with the largest number and concentration of herds and sheep farms in ZDC (Zenica and Zepce). In total during the epidemic and non epidemic period we registered 294 patients. The number of occasional cases is contained within the total number of cases reported during epidemics.

Analysis of the electroencephalogram and pain characteristic in patients before and after carbamazepine treatment.

GOAL OF THE STUDY: To determine the changes of the electroencephalogram and the changes of the quantity in percentage terms of alpha, beta, theta and delta waves in the electroencephalogram in migraine patients after a carbamazepine treatment. Analyze pain characteristics after the carbamazepine treatment of these patients and the efficiency of the carbamazepine treatment in the prevention of new attacks. PATIENTS, METHODS, RESULTS: A retrospective-prospective study has been conducted on 40 persons of approximately 42,9 years of age, with normal cranium CT finding, craniogram and fundus. They were divided in two groups: Group A--21 person who prophylactically took a daily dosage of 400 mg Carbamezepin and during acute pain attacks Naproksen; and group B--19 persons who prophylactically took daily dosage of 400 mg Carbamezepin. EEG test was done twice--before and after the medication, in order to check the concentration of different waves in the EEG in percentages. The T-test doesn't show a statistically significant difference between the alpha (p 0,719), beta 1 (p 0,865), beta 2 (p 0,710), theta (p 0,867) and delta (p 0,272) waves for the group A and for the group B alpha (p 0,996), beta 1 (p 0,920), beta 2 (p 0,826), theta (p 0,324) and delta (p 0,820) waves, on the significance level p 0,05 in the EEG at the beginning and the EEG at the end of the examination. The t-test does show a statistically significant difference between the intensity, frequency, duration and relief of pain at the beginning and at the end of the examination for both test groups. CONCLUSION: Carbamazepin and Paracetamol do not cause changes in the EEG nor in the quantity in percentage terms of concentration of different waves in the control EEG in patients with vascular headaches. Statistically Carbamazepin and Paracetamol significantly change characteristics of pain and can be used for migraine treatment and prophylaxis.

The advantages and limitations of international classification of diseases, injuries and causes of death from aspect of existing health care system of bosnia and herzegovina.

CONFLICT OF INTEREST: NONE DECLARED. INTRODUCTION: The International classification of diseases (ICD) is the most important classification in medicine. It is used by all medical professionals. CONCEPT: The basic concept of ICD is founded on the standardization of the nomenclature for the names of diseases and their basic systematization in the hierarchically structured category. ADVANTAGES AND DISADVANTAGES: The health care provider institutions such as hospitals are subjects that should facilitate implementation of medical applications that follows the patient medical condition and facts connected with him. The definitive diagnosis that can be coded using ICD can be achieved after several visits of patient and rarely during the first visit. CONCLUSION: The ICD classification is one of the oldest and most important classifications in medicine. In the scope of ICD are all fields of medicine. It is used in statistical purpose and as a coding system in medical databases.