RESUMO
The immunogenetic features of the HLA system were studied in 116 Kirghiz patients with pulmonary tuberculosis and 120 apparently healthy individuals of the same nationality (a control group). HLA antigen typing was made by the routine microlymphocytotoxic test. The antigens Bw53, Bw62(15), DR2 and DR7 which should be regarded as markers of the disease were more commonly found in the HLA phenotype in Kirghiz patients with tuberculosis than in healthy individuals. The risk for tuberculosis increased in carriers having HLA haplotypes with the DR allele.
Assuntos
Genes MHC da Classe II/imunologia , Genes MHC Classe I/imunologia , Tuberculose Pulmonar/imunologia , Feminino , Marcadores Genéticos , Antígenos HLA/imunologia , Haplótipos , Heterozigoto , Humanos , Quirguistão , Masculino , Linhagem , Fenótipo , Fatores de Risco , Tuberculose Pulmonar/genéticaRESUMO
Tuberculosis incidence and mortality rates are rising steeply, reflecting economic hardship and the deterioration of the health infrastructure. The human and technical resources needed to reverse this trend are on hand, but cannot be used effectively without an adequate financial input. The cost of controlling tuberculosis now is modest compared with the cost of allowing it to increase.