Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Hospitalised Patients with Co-Infections and Clinical Outcomes.

The clinical severity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection may rise because of acquiring a co-infection during the hospital stay of the patients. The rate of hospital co-infection alongside COVID-19 infection remains low. However, the mortality rates and intensive care unit (ICU) admission remains ambiguous. The present study investigates the implications of COVID-19 hospitalised infected patients with co-infection and the clinical outcomes. In this study, 142 patients were included. The eligible patients who tested positive for COVID-19 infection were hospitalised for more than two days. Each patient's characteristics and laboratory results were collected, such as who was admitted to the intensive care unit and who was discharged or expired. The results revealed that out of the 142 hospitalised patients, 25 (17.6%) were co-infection positive, and 12 identified types of co-infection: two Gram-positive bacterial infections, one fungal infection and nine Gram-negative bacterial infections. In addition, 33 (23.2%) were ICU admitted, 21 were co-infection negative and 12 were co-infection positive. Among the 12 ICU admitted with co-infection, 33.4% were discharged. The death rate and ICU admission had a p-value < 0.05, indicating statistical significance for co-infected patients compared to non-co-infected patients. It was concluded that co-infection remains very low within hospitalised COVID-19-infected patients but can have severe outcomes with increased ICU admission and increased mortality rates. Thus, implementing infection preventive measures to minimize the spread of hospital-acquired infections among COVID-19 hospitalised patients.

A Cytological Study of Oral Human Papillomavirus (HPV) Infection Among Electronic Cigarette Smokers in Al-Madinah Al-Munawara.

Objective This study aims to determine how electronic cigarette (e-cigarette) use contributes to the spread of the human papillomavirus (HPV) and to assess the potential cellular proliferative activity it may produce. Methodology In Madinah, a case-control study was conducted between October 2022 and March 2023. Two oral cytologic smear samples were collected from each of the 500 volunteers; 250 consumers of electronic cigarettes and 250 non-smokers each provided two samples. To detect cytological changes and HPV infection, these samples were stained using Papanicolaou and immunocytochemical techniques. Results Twelve (4.8%) of the electronic cigarettes exhibited cytological atypia, while only one (0.4%) of the nonsmokers' group did. Infection with the human papillomavirus (HPV) was detected in eight (3.2%) of the e-cigarette users, but it was only found in two (0.8%) of the nonsmokers (P ≤ 0.05). Conclusion Electronic cigarette smoking increases the likelihood of contracting HPV and developing cytological atypia, both of which, if left untreated, can contribute to the development of precancerous and cancerous lesions in the mouth.

Knowledge, Attitudes, and Practices of Military Personnel Regarding Heat-Related Illness.

INTRODUCTION: Heat-related illnesses are a global concern, affecting millions of people and leading to numerous deaths annually. Since military personnel are exposed to heat, the purpose of the study was to evaluate military personnel's knowledge, attitudes, and practices (KAP) related to heat-related illnesses. Their KAP may help to prevent heat-related illness.  Methods: We conducted a cross-sectional study using a structured online questionnaire on 168 military personnel who were training and working in a high-temperature and high-humidity environment all year round in Jeddah, Saudi Arabia. The questionnaire assessed the KAP and associated factors and was distributed as a Google Form. RESULTS: The mean knowledge score was 9.04 (range = 2-13, SD = 1.832), the mean awareness score was 9.61 (range = 4-15, SD = 2.415), and the mean practice score was 3.39 (range = 0-6, SD = 1.703). Most participants correctly identified symptoms (n=130; 77.4%). In terms of attitudes, most participants showed a good attitude (n=151; 81%), though 24.4% did not perceive the risk. Regarding practice, most were attentive to heat-related illness signs and hydration(75.6%), but there were gaps in receiving briefings from doctors (69%) and adequate guidance on treatment (56%). There was a split opinion on whether commanders adjust field activities based on temperature warnings (54.8% Yes, 45.2% No). There were no significant differences in knowledge scores based on age or educational level (both p>0.05), while some age and education-related differences were noted in practice scores (p<0.05). There was a positive correlation between knowledge and attitudes (r = 0.222, p = 0.004), knowledge and practices (r = 0.165, p = 0.033), and attitudes and practice (r=0.326, p < 0.001). CONCLUSION: Our study found that military personnel generally possess good knowledge of heat-related illnesses and good attitudes and practices concerning heat-related illnesses. However, there are areas in need of improvement, and enhancing awareness and practical implementation of preventive measures, along with the development of precise guidance and protocols, should involve active collaboration between military commanders and healthcare professionals.