Spinal epidural haematoma as a result of warfarin/fluconazole drug interaction.

This is the first reported case in the emergency medicine literature of a drug interaction between warfarin and fluconazole. We present a case of spinal epidural haematoma and summarize four other case reports reported elsewhere from 1988 to 1996. We admonish emergency physicians to be aware of this dangerous drug combination. Warfarin and fluconazole are frequently encountered drugs in the emergency department and thus any interaction between these drugs is of considerable importance.

Exertional rhabdomyolysis in a body builder abusing anabolic androgenic steroids.

Rhabdomyolysis, or acute skeletal muscle destruction, may be accompanied by myoglobinaemia, myoglobinuria, and an elevated serum creatine kinase level. This disorder has many potential causes. In this article, the authors describe a case of rhabdomyolysis occurring after vigorous weight lifting by a man who was supplementing his weight-training programme with the intake of anabolic androgenic steroids dispensed to him by a colleague.

Elder abuse and neglect: the emergency medicine perspective.

The diagnosis of elder abuse and neglect is difficult to accomplish, making intervention elusive, primarily because to date there is no set definition of either abuse or neglect. This paper, written primarily from the American viewpoint, addresses definitions; assessment and diagnosis; aetiology of abuse; intervention; prevention and management; ethical and legal considerations; elder abuse and the emergency physician; and future goals.

Extortion in the emergency department.

We present the case of a 33-yr-old female patient who, along with members of her family, attempted to extort approximately $6000.00 from our institution and her insurance company. This attempted extortion was done under the guise of a missed retained foreign body. The patient initially presented to our emergency department with a laceration to her right forearm; X-ray studies obtained after the wound had been sutured revealed no foreign body. Several days later, the patient and family members approached our administrative staff demanding recompense for metal fragments discovered in the patient's wound at another facility. Comparison of radiographs revealed that the metallic fragments were placed in the wound after she was treated and released from our emergency department, and monetary compensation was denied.

Photograph documentation of motor vehicle damage by EMTs at the scene: a prospective multicenter study in the United States.

The purpose of this study was to determine if emergency medical service (EMS) personnel could take instant photographs of motor vehicle damage at crash scenes depicting the area and severity of damage of the crash under adverse weather conditions, in different lighting, and quickly enough so as not to interfere with patient care. This prospective multicenter trial involved 35 ambulances responding to motor vehicle crash scenes in rural, suburban, and urban areas in five centers in four states. Emergency medical technicians (EMTs) reported their experience implementing a protocol for use of an instant camera to photograph vehicle damage at crash scenes. Time reported by EMTs to take the photographs was 1 minute or less in 204 of 288 (70.9%) of motor vehicle crashes and 2 minutes or longer in 12 of 288 (4.2%) of motor vehicle crashes. From one EMS agency in the study, 48 scene times during which photographs were taken were, on average, 1.5 minutes shorter than 48 scene times immediately before implementation of on-scene crash photography. Photographs were taken in different weather and lighting conditions. EMTs reported they were able to determine both area and severity of damage in 260 of 290 (92.5%) crash photographs, but they were unable to determine area and severity of damage in only 2 of 290 (0.7%) crash photographs.

Acute myocardial infarction in a 16-year-old boy with no predisposing risk factors.

Chest pain in the pediatric age group is a common presentation to the emergency department and rarely signifies underlying cardiopulmonary pathology. However, when chest pain occurs in association with symptoms such as dyspnea, diaphoresis, or syncope/near-syncope, a cardiac etiology must be urgently considered. We present the case of an otherwise healthy adolescent male patient with no discernible risk factors for coronary artery disease or other heart disease who experienced a myocardial infarction.

Patient and physician perception of need for emergency medical care: a prospective and retrospective analysis.

The purpose of this study was to examine patients' and physicians' perceptions of the urgency of need for emergency medical care, and why patients come to the emergency department (ED). Survey instruments were utilized at EDs at an academic tertiary care center and a community hospital. Physicians' prospective assessment indicated that 65.8% (921 of 1,400) of the patients seen needed attention within 12 hours, whereas the patients' perception was that 86.5% (957 of 1,106) needed care within 12 hours. Patients' and physicians' retrospective responses were compared; in 19.5% (152 of 781) of cases patients rated urgency of their condition lower than the physician. These results indicate that patients and the physicians who treat them, despite the passage of a decade since a previous report of a similar study and a vastly different patient and physician population, have similar perceptions of the need for emergency care. Additionally, patients presented to EDs for a multitude of reasons; however, in strikingly different patient populations, a number of reasons are identified consistently.

Black widow spider bite in a child.

An 8-year-old boy who was bitten by a black widow spider was seen in the emergency department twice, as well as by his private family physician, within a 24-hour period of time before being admitted to the hospital. This patient should have been observed for a longer period of time in the emergency department or admitted to the hospital on the day of presentation for observation with conservative management. The current literature is reviewed with special emphasis on the pediatric patient, and management guidelines are recommended.

Vascular prostheses.

The quest for an ideal vascular graft began in the early 1950s and continues at a steady pace. The perfect graft has yet to be designed. As a result, patients with vascular prostheses may suffer complications that range from minor to catastrophic. The emergency physician may be faced with the initial presentation of patients with these vascular graft complications. If he or she is not familiar with these possibilities, then the resulting morbidity and mortality could be devastating. Probably the most unnerving complication involving the failure of vascular prostheses is that of the aortoenteric fistula. Instantaneous decisions and interventions must be made when a patient presents in this state of pre-exsanguination. Massive GI bleeding is at one end of the spectrum with other less-severe GI complications involving aortoenteric erosions and small bowel obstructions due to graft migration at the other end of the spectrum. Infection of a vascular prosthesis is a complication much feared by vascular surgeons. A spectrum of presentation also exists here whereby a patient may present with an obvious draining wound or with subtle complaints of fever, weakness, and a minimally elevated white blood cell count. The function of the emergency physician is critical here but only if he or she is able to suggest the possibility of graft infection to the admitting physician. Fortunately, thrombosis of a vascular graft is an infrequent complication that may occur at any time postoperatively, although the frequency decreases with time. There are many different causes of graft occlusion of which the emergency physician should be aware. If the cause of the thrombosis is known, then the secondary vascular reconstruction can be optimized. The dialysis population has grown rapidly over the past two decades and as a result so have complications of renal dialysis grafts. Because the dialysis population now includes large numbers of older subjects as well as those with systemic diseases such as diabetes and HIV, recognition and prompt aggressive management of clinical complications is of paramount importance.

Work-related stress and depression among practicing emergency physicians: an international study.

STUDY OBJECTIVE: To compare the levels of work-related stress and depression reported by practicing emergency physicians in three survey sites and to determine the effects of gender and marital status on the stress and depression experienced by these physicians. DESIGN: Cross-sectional mail surveys. SETTING AND PARTICIPANTS: Seven hundred sixty-four practicing emergency physicians from the United States, 91 fellows in full-time practice from Australasia, and 154 consultants and 47 senior registrars from the United Kingdom. INTERVENTION: Administration of questionnaires requesting demographic information and including an inventory to assess work-related stress and a scale to measure depressive symptomatology. MEASUREMENTS AND MAIN RESULTS: A 3 x 2 x 2 multivariate analysis of variance performed to compare scores on the stress inventory and depression scale simultaneously by survey site, gender, and marital status revealed significant differences in stress and depression by survey site and marital status. Univariate analyses of variance revealed significant differences in both stress and depression among the three survey sites and in depression by marital status. Adjusted means indicated that physicians from the United Kingdom reported higher levels of stress and depression than physicians from the United States and Australasia. Physicians from the United States and Australasia did not differ with respect to stress or depression. Physicians who were not married reported higher levels of depression than married physicians. No large mean differences, actual or adjusted, were found for any of the grouping factors. CONCLUSION: Statistical differences among practicing emergency physicians from the United States, Australasia, and the United Kingdom were observed, but the actual levels of work-related stress and depression were similar and did not appear severe. Marriage was associated with lower levels of depressive symptomatology.

Environmental temperature variations cause degradations in epinephrine concentration and biological activity.

This study determined the biological consequence of temperature induced epinephrine degradation. Two different epinephrine preparations (1:1,000 and 1:10,000) were exposed to either cold (5 degrees C) or hot (70 degrees C) temperature. The exposure occurred for 8-hour periods each day in 4-, 8-, and 12-week intervals. Samples and identical controls were then chemically evaluated using high-pressure liquid chromatography (HPLC), and biological activity of samples showing chemical degradation was assessed in conscious rats. Epinephrine (1:10,000) underwent a significant degradation and a loss of concentration of the parent compound after 8 weeks of heat treatment. By 12 weeks, 64% of the epinephrine was degraded. A smaller (30%) but significant loss of cardiovascular potency was determined by blood pressure and heart rate responses in conscious rats. The degradation of epinephrine (1:1,000) was not statistically significant even after 12 weeks of heat exposure. No change was noted from control in either epinephrine concentration when exposed to cold temperatures. In conclusion, epinephrine (1:10,000) deteriorates in the presence of elevated temperature and should be protected from high temperatures when carried by EMS providers. The degradation products may possess biological activity.

Correlates of work-related stress among consultants and senior registrars in accident and emergency medicine.

A mail survey was conducted of consultants and senior registrars practising accident and emergency (A&E) medicine in the United Kingdom. The 201 respondents (72%) comprised 154 consultants (70.6%) and 47 senior registrars (77%), who provided demographic information and completed inventories measuring stress, depression, task and role clarity, work group functioning and overall satisfaction with work. The respondents did not report particularly high levels of stress or depression and generally evaluated aspects of their work environments favourably. Higher levels of stress were reported by consultants and respondents from district general hospitals. Levels of stress were similar to those reported by other groups of health care providers. Respondents generally considered tasks and roles to be clearly defined, work groups to be supportive, efficient units and work satisfying. There was no statistically significant correlation on the affective scales for the number of patient attendances, on call commitment or staffing numbers. Senior staff with more than 10 years experience in the specialty reported more satisfaction with work and work group functioning, and perceived their tasks and roles to be significantly clearer. Consultants over 45 evaluated their work groups favourably and were more likely to view them as cohesive, smoothly functioning units than senior registrars. The results probably reflect the ad hoc coping strategies adopted by a group of doctors, who have already demonstrated appropriate personality characteristics by completing a long training programme, with no realistic alternative late career opportunities. To prevent mid or late career attrition, however, A&E doctors should receive formal training in stress recognition and avoidance. Accessible counselling without stigma should be easily available. Senior A&E doctors have a role in detecting and managing stress amongst other staff in the department.

Predictors of work satisfaction among SHOs during accident and emergency medicine training.

The purpose of this study was to assess the ability of work-related stress, and other work environment characteristics that might affect stress, to predict work satisfaction among senior house officers (SHOs) during accident and emergency (A&E) training. Questionnaires were returned by 365 SHOs, who indicated their year in training, the number of hours worked per week, the type of training hospital, the number of new A&E attendances per year, the ratios of patients and consultants to SHOs at their training hospitals and their likelihood of specializing in A&E. They also completed inventories measuring work-related stress, task and role clarity, work group functioning and work satisfaction. Scores on the satisfaction scale served as the dependent variable in a multiple regression equation. Using an alpha level of 0.05, a significant relationship was detected between satisfaction and the 10 independent variables (P = 0.0001). Direct relationships between task and role clarity (P = 0.0001) and work group functioning (P = 0.0002) were significant, as were inverse relationships between stress (P = 0.0001) and the number of new attendances (P = 0.0321). Management practices, such as orientation sessions, that define tasks and roles, enhance work group cohesiveness and mitigate against stress, should result in increased satisfaction among SHOs.

Thrombolytic therapy in review.

The use of thrombolytic agents for both coronary and noncoronary indications is a rapidly progressing field. There has been substantial debate over which disease processes ultimately benefit from the use of thrombolytic agents. In addition, many recent studies have focused on comparing different thrombolytic agents and dosing regimens in an attempt to gain optimal therapeutic benefit with minimal risk. This paper discusses the current status of thrombolytic therapy for coronary artery disease, pulmonary embolus, peripheral vascular thrombosis, and cerebrovascular infarction.