1.
Mem Inst Oswaldo Cruz
; 104(5): 703-5, 2009 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19820828
RESUMO
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.
Assuntos
Amino Álcoois/farmacologia , Antituberculosos/farmacologia , Diaminas/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Amino Álcoois/síntese química , Antituberculosos/química , Diaminas/síntese química , Testes de Sensibilidade Microbiana
2.
Mem. Inst. Oswaldo Cruz
; 104(5): 703-705, Aug. 2009. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-528076
RESUMO
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.