Human Herpesvirus 8-Positive Multicentric Castleman Disease in an Immunocompetent Patient: A Diagnostic Challenge.

We present a clinical case of a 79-year-old male admitted to inpatient care for longstanding asthenia and respiratory symptoms. Associated features were polyserositis, multiple enlarged lymphatic nodules, acute kidney injury, and heart failure. The patient's recent medical history revealed SARS-CoV-2 vaccination a week prior and an upper respiratory tract infection. The laboratory results from thoracentesis were compatible with a transudate, with no immunological stain. Epstein-Barr virus polymerase chain reaction (PCR) was positive. The thoracic, abdominal, and pelvic CT scans revealed multiple enlarged lymphatic nodules, worsening the pre-existent polyserositis and hepatosplenomegaly. The patient began to show signs of neurologic symptoms and deterioration of the global health status. An enlarged lymphatic nodule was excised and the pathology showed human herpesvirus 8 multicentric Castleman disease. The disease evolved rapidly into hematological dysfunction and blood transfusions were necessary. Even though the patient was started on high-dose rituximab therapy combined with etoposide, the disease evolved into multiorgan dysfunction with a fatal outcome.

Does thermoplastics' thickness influence joint stabilization and movement coordination? An inferential study of wrist orthoses.

BACKGROUND: Given the existence of multiple low-temperature thermoplastics, clinicians fabricating can readily modify an orthoses' thickness, weight and flexibility, among other properties. However, there is limited evidence on the impact of such different materials on upper extremities' biomechanics. OBJECTIVE: Our study aimed to investigate differences in joint stabilization and movement coordination provided by upper extremity orthotics fabricated with low-temperature thermoplastics of different thicknesses. STUDY DESIGN: Inferential, cross-sectional study. METHOD: We conducted a kinematic analysis of a standardized task through a three-dimensional motion capture system. Ten participants (5 female) performed the same task under three circumstances: 1) wearing a volar wrist immobilization orthosis, made with a 3.2-mm thick low-temperature thermoplastic; 2) using the same orthotic fabricated with a 1.6-mm thick material; and (3) without orthoses. We divided the standardized task into five logical phases for data analysis, obtaining the active range of motion of the shoulder, elbow, forearm, and wrist joints as the primary outcome. Secondary outcomes included movement smoothness and coordination, measured by the number of motor units, time, and distance travelled by the upper extremity. RESULTS: Despite changes in thermoplastic thickness, both orthotics significantly restricted the wrist motion during task performance (F(2,16) = 14.32, P < .01, and η2p = 0.797), with no difference between the 2 devices and no significant changes to proximal joints' active range of motion. Although orthoses use increased the time required for task performance (F(2,16) = 23.05, P < .01, and η2p = 0.742), no significant differences in movement smoothness or coordination were noted. CONCLUSION: Our results indicate that wrist orthoses fabricated with a 1.6-mm thick low-temperature thermoplastic can provide joint stabilization similar to a device made from a 3.2-mm thickness material, suggesting thinner thermoplastics' efficacy to stabilize joints in the absence of contractures or preexisting chronic conditions.

Psychometric Properties of the Patient-Specific Functional Scale in Patients with Low Back Pathology: A Systematic Review and Meta-Analysis.

Purpose: This systematic review and meta-analysis identifies, critically appraises, synthesizes, and meta-analyses the reported psychometric properties of the Patient-Specific Functional Scale (PSFS) in patients with low back pain or pathology. Method: The MEDLINE, Embase, PubMed, and Google Scholar databases were searched from their inception to September 2019. We included prospective measurement studies that reported on the psychometric properties (reliability, validity, responsiveness) of the PSFS in people with low back pain or pathology. We followed the COnsensus-based Standards for the selection of health Measurement INstruments 2018 guideline for systematic reviews. We performed both quantitative and qualitative syntheses in which the results were summarized on the basis of the reported measurement properties and study quality. Results: Ten eligible studies were included. The pooled PSFS reliability measure was excellent (intra-class correlation coefficient = 0.89; 95% CI: 0.75, 0.95). Validity measures displayed correlations that ranged from -0.47 to 0.69 when compared with other patient-reported outcome measures (PROMs) or other tests. Eight studies had assessed the responsiveness of the PSFS. Effect sizes reported were large (≥ 0.91). Conclusions: The PSFS is a reliable, valid, and responsive PROM for patients with low back pain or pathology.

Objectif : procéder à la détermination, à l'évaluation critique, à la synthétisation et à la méta-analyse des propriétés psychométriques déclarées de l'échelle fonctionnelle propre aux patients (PSFS) ayant des douleurs ou une pathologie dorsales. Méthodologie : les chercheurs ont consulté les bases de données MEDLINE, Embase, PubMed et Google Scholar depuis leur création jusqu'en septembre 2019. Ils ont inclus les études de mesures prospectives sur les propriétés psychométriques (fiabilité, viabilité, réactivité) du PSFS chez les personnes souffrant de douleurs ou d'une pathologie dorsales. Ils ont respecté les directives COSMIN 2018 sur les normes consensuelles pour la sélection d'instruments de mesure de la santé en vue d'analyses systématiques. Ils ont effectué à la fois une synthèse quantitative et une synthèse qualitative dans lesquelles ils ont résumé les résultats en fonction des propriétés métriques déclarées et de la qualité des études. Résultats : dix études admissibles ont été retenues. La mesure de fiabilité regroupée de la PSFS était excellente, avec un coefficient de corrélation intraclasse de 0,89 (IC à 95 % : 0,75, 0,95). Les mesures de validité ont révélé des corrélations entre −0,47 et 0,69 par rapport à d'autres mesures de résultats déclarées par les patients (PROM) ou d'autres tests. Huit études ont évalué les mesures de réactivité du PSFS. Les ampleurs de l'effet déclarées étaient importantes, à 0,91 ou plus. Conclusion : la PSFS est une PROM fiable, valide et réactive chez les patients ayant des douleurs ou des pathologies lombaires.

The clinical outcome of physiotherapy after reversed shoulder arthroplasty: a systematic review.

PURPOSE: The purpose of this systematic review was to analyze the current literature on the clinical outcomes of physiotherapy (PT) program after reversed total shoulder arthroplasty (rTSA) and to summarize the improvements in this population. METHODS: A search was performed in four databases (MEDLINE, Embase, PubMed, Google Scholar) from its inception to 30 April 2020. Data were extracted to describe the study design and rehab programs. The quality of evidence was assessed as high, moderate, and low-level according to the Evaluation of Quality of an Intervention Study critical appraisal criteria. RESULTS: There were 22 eligible studies including two randomized controlled trials, four prospective cohort studies, 10 retrospective reviews, five case-series, and one case-control study, with the sample sizes ranging from 9 to 474 patients followed for 1-10 years. All studies indicated substantial improvement in patients after PT program in terms of functional outcomes and forward flexion. CONCLUSIONS: High-quality RCTs are required to provide more conclusive results. We identified substantial variation in the post-operative PT programs except for the progressive mobilization strategy and the common management following surgery to increase the soft tissue healing within 4-6 weeks.Implications for RehabilitationThe reverse shoulder arthroplasty (rTSA) has been widely utilized for patients with rotator cuff arthropathy, primary arthritis, and proximal fractures.A successful outcome of rTSA is not only depending on the surgical management, but also depended on physiotherapy (PT) programs.Our systematic review concluded that a 12-week PT program starting with immobilization for 4-6 weeks, followed by 3-4 phases PT exercises including PROM, AAROM, AROM, and strength training was recommended as common management for patients received rTSA.Due to the huge variation in the included studies, the evidence of PT protocol in our study was not sufficient to summarize the better clinical practice suggestions regarding rTSA rehabilitation.

Short-Term Impact of Social Distancing Measures During the COVID-19 Pandemic on Cognitive Function and Health Perception of Brazilian Older Adults: A Pre-Post Study.

Social distancing, a critical measure to manage COVID-19 transmission, is consistently associated with social isolation, a major health issue. Social isolation negatively impacts mental and physical health, particularly among older adults. A pre-post comparison study examined changes in cognitive function and perceived health among 36 community-dwelling Brazilian older adults, assessed pre and post social distancing measures enacted due to COVID-19. A significant increase in cognitive function was found 1 month into social distancing (M = 16.3, p = .002, power = 0.88), with declining scores for vitality (M = -29.3, p < .001, power = 0.99) and mental health (M = -38.1, p < .001, power = 0.99), particularly among participants who lived alone (t = -3.8, p = .001). Older adults exhibit rapid changes in perceived health when excluded from participation in social activities. Health care professionals should consider holistic approaches when addressing the impacts of social isolation on this population.

Orthotic use for CMC osteoarthritis: Variations among different health professionals in Brazil.

STUDY DESIGN: Cross-sectional descriptive study. INTRODUCTION: Osteoarthritis (OA) is the most prevalent musculoskeletal disease in the adult and older adult populations. The use of orthoses to stabilize the thumb's articular complex is one of the most common conservative management strategies. Despite substantial research about this topic, there is insufficient evidence about the optimal use of orthoses to inform clinical practice, contributing to practice variations within and across health professionals. PURPOSE OF THE STUDY: To identify the prescription patterns, design preferences, and barriers for the use of orthotic devices among Brazilian health care professionals involved in the treatment of patients with OA of the basal thumb joint. METHODS: An electronic questionnaire was sent to occupational therapists, physiotherapists, and rheumatologists across Brazil through professional association mailing lists. Survey included questions about orthosis design, materials, and barriers to the use of orthotic interventions. Respondents indicated their use based on photographs of 25 orthoses models that were selected through bibliographic review and expert consultation. Descriptive statistics, the chi-square test for independence, and the Fisher exact test were used to compare differences among orthotic prescription preferences, barriers, and challenges observed amidst the 3 participants' professional classes. RESULTS: There was no consensus about orthotic prescription among 275 professionals who answered the survey. About 69% of participants reported the use of multiple orthosis during treatment of patients with thumb OA. Results suggest significant variations in the number of joints included and stabilization strategies adopted, with a preference for orthotics made in rigid materials and involving the wrist, carpometacarpal, and metacarpophalangeal joints (P < .001). The lack of knowledge about orthotic options, institutional regulations, and policies were the major barriers reported by respondents (P < .01). CONCLUSION: A plentiful variety of different orthoses designs were observed in this study, and the prescriptions made by 3 professional classes showed differences regarding types of stabilization, joint involvement, and positioning. Despite the existence of clinical trials suggesting benefits for specific custom-made design models, our results indicated widespread clinical variation in practices and preferences. LEVEL OF EVIDENCE: Not applicable.