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J Zoo Wildl Med ; 51(4): 994-998, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33480580

RESUMO

Ketamine-free, midazolam-based protocols have successfully immobilized cervids in the past but their impact on physiological function has not yet been thoroughly investigated. Six deer received IM dexmedetomidine (30.96 ± 3.06 µg/kg) and midazolam (0.31 ± 0.03 mg/kg). Heart rates (HR), respiratory rates (f ), rectal temperature, mean arterial blood pressure (MAP), and oxygen saturation (SpO2) were recorded 25 min after drug delivery (T25) and every 5 min until T55. An arterial blood sample was collected at T40. Mean HR and temperature significantly decreased throughout sedation, but were maintained above critical values (> 60 beats/ min and 37°C, respectively). Although not statistically different, f clinically decreased during sedation. MAP remained within acceptable ranges (60-80 mmHg) and SpO2 above 95%. Mean PaO2 was normal (>80 mmHg), but a mild hypoxemia was observed on two occasions. Recovery was smooth yet prolonged, as the first head movement, attempt to stand, sternal recumbency, and standing position were recorded within 9.36 ± 3.47, 10.32 ± 1.37, 13.13 ± 2.70, and 15.34 ± 2.57 min after IM atipamezole, respectively. This protocol was effective for short-term procedures in captive brown brocket deer, and appeared to be safe on the basis of arterial blood gases and cardiorespiratory variables.


Assuntos
Cervos , Dexmedetomidina/farmacologia , Frequência Cardíaca/efeitos dos fármacos , Imidazóis/farmacologia , Midazolam/farmacologia , Fenômenos Fisiológicos Respiratórios/efeitos dos fármacos , Antagonistas de Receptores Adrenérgicos alfa 2/administração & dosagem , Antagonistas de Receptores Adrenérgicos alfa 2/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Dióxido de Carbono/sangue , Dexmedetomidina/administração & dosagem , Eletrólitos/sangue , Hipnóticos e Sedativos/administração & dosagem , Hipnóticos e Sedativos/farmacologia , Imidazóis/administração & dosagem , Midazolam/administração & dosagem , Oxigênio/sangue
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