High prevalence of cardiac post-acute sequelae in patients recovered from Covid-19. Results from the ARCA post-COVID study.

Background: Many data were published about Long-Covid prevalence, very few about the findings of new cardiac alterations (NCA) in COVID-19-recovered people. ARCA-post-COVID is an observational study designed to investigate the prevalence of NCA in patients recovered from Covid-19.Methods: from June 2020 to December 2022, we enrolled 502 patients with a positive nasopharyngeal swab for SARS-CoV2 and a subsequent negative one. We performed anamnesis, lab-test, and routine cardiological tests (ECG, Holter, TTE). Results: The median age was 56 years (IQR 44-67); women were 52.19%; in the acute phase 24.1% of patients were treated in a medical department, 7.2% in the ICU and the others at home. At the visit, 389 patients (77.49%) complained of a broad range of symptoms. We reported patients' characteristics according to the course of the disease and the persistence of symptoms. NCA were found in 138 patients (27.49%): among them 60 cases (11.95%) of pericardial effusion. Patients with NCA were older (median 60y, IQR: 47-72, vs median 56y, IQR 42-65), had a higher prevalence of smokers (27% vs 17%; p0.014), CAD (11% vs 6%; p0.048) and stroke/TIA (3.6% vs 0.3%; p0.002) and a lower prevalence of hypercholesterolemia (18% vs 30%; p0.007). The prevalence of NCA seems constant with different subtypes of the virus. Conclusion: the prevalence of NCA in patients who recovered from COVID-19 is high and constant since the beginning of the pandemic; it is predictable based on hospitalization and long-lasting symptoms (9.64%-42.52%). Patients with one of these characteristics should undergo cardiological screening.

Performance of Rigid and Soft Transfer Templates Using Viscous and Fluid Resin-Based Composites in the Attachment Bonding Process of Clear Aligners.

OBJECTIVES: The study aims at assessing the accuracy of the process of attachment bonding in aligner treatments. The analysis leads to the error estimation in the faithful reproduction of master model attachments using two types of transfer templates and two light-curing resin-based composites usually used in orthodontics. METHODS: The authors have used two transfer templates made of two different materials. The first, named Leone-biocompatible thermoforming material hard/soft, has a lower Young's modulus and is labelled as soft, while the other, named Leone-biocompatible thermoforming material, is marked as rigid. The resin-based composites possess different mechanical and rheological properties. Specifically, Transbond™ XT Light Cure Paste Adhesive, 3M has a higher viscosity than the TetricEvoflow, Ivoclar Vivadent, a flowable nanohybrid composite. The authors attempt to estimate the performance ranking between the four possible couples obtained by combining the two light-curing resin-based composites and transfer templates. Each combination was repeated in six models and compared with twelve master models, resulting in 36 total samples. A 3-D laser scanner is used to generate a digital model of each model. The comparison between digital models is the base for a comparative assessment in terms of relative and absolute error. The relative error is estimated using scalar performance indicators ranging from 0 to 1, where 1 indicates the optimum matching. The absolute error estimated from the mean square error between the coordinates of each digital model yields the reproduction accuracy in micrometer. Furthermore, the authors attempted to assess the error distribution by evaluating the point-by-point difference between the digital models. RESULTS: This analysis aims at localizing the sources of error in the considered models. The use of Transbond™ XT Light Cure Paste Adhesive, 3M with a rigid transfer template is always associated with significant accuracy and minor dispersion. However, in a few instances, using the soft template or the flowable resin-based composite can lead to bad performances. Significance. The data processing bestowed the following performance ranking from the first with lower reproduction error to the last characterized by the worst performance: (1) attachments bonding with rigid template and Transbond™ XT Light Cure Paste Adhesive, 3M, (2) attachments bonding with soft template and Transbond™ XT Light Cure Paste Adhesive, 3M, (3) attachments bonding with rigid template and TetricEvoflow, Ivoclar Vivadent, and (4) attachments bonding with soft template and TetricEvoflow, Ivoclar Vivadent.

A new interpretation of nonpulmonary vein substrates of the left atrium in patients with atrial fibrillation.

BACKGROUND: Substrate analysis of the left atrium in patients undergoing atrial fibrillation ablation has limitations when performed by means of simple bipolar acquisition. OBJECTIVE: To evaluate the incidence of low-voltage zones (LVZs) through maps constructed by means of various catheters: multipolar (MC), omnipolar (OC), and circular catheters (CMCs) with the 3D electro-anatomical systems (3d-S) CARTO3 and EnSite Precision. METHODS: To assess LVZs, we acquired maps by means of CMC and MC in the voltage range 0.05-0.5 mV in 70 consecutive patients in sinus rhythm. In the case of OC only, we made an intra-patient comparison of bipolar maps constructed by means of the along and across, and HD-Wave configurations of the EnSite 3d-S in the ranges of 0.05-0.5 and 0.5-1.0 mV. On the basis of this comparison, we chose the range that best identified LVZs as a set of different colors (SDC) compatible with patchy fibrosis (qualitative analysis). Subsequently, we detected the voltage values corresponding to purple and gray points, close to SDC, and the value inside corresponding to blue, green, and red colors, and we evaluated the color change in other voltage ranges. Finally, we performed a quantitative analysis of LVZs by applying the qualitative characteristics described above. RESULTS: On the basis of our settings, for OC, the optimal range identifying LVZs was 0.3-0.6 mV. OC revealed smaller LVZs than MC (P < .05 or P < .001), except in the lateral wall. No significant differences were observed between CMCs. CONCLUSIONS: In our experience, OC does not present the limits of bipolar HD maps, though further studies are needed in order to confirm that 0.3-0.6 mV is the optimal voltage range within which to identify LVZs.

Effectiveness of Implantable DEfibrillators Alert Systems: comparison between audible and vibratory alert: IDEAS study.

INTRODUCTION: Implantable cardioverter-defibrillator (ICD) alarm systems are an important means of monitoring device functioning. The aim of this study was to compare the ability of patients with sense two types of device alert systems: an audible alert and a vibratory alarm. METHODS: The ability to recognize the alarms was assessed in three alarm tests performed in a series of consecutive ICD patients enrolled during routine outpatient device follow-up. To avoid overestimating the rate of patients able to sense the alarm, the first test was performed without forewarning. Subsequently, the second test was performed after the patients had been forewarned. Finally, to assess the learning effect of a demonstration test, a third test was performed, again without forewarning. RESULTS: A total of 528 patients (65.4 ±â€Š14.4 years, 74.6% male) were enrolled: 347 (65.7%) with an audible alert-endowed device and 181 (34.3%) with a vibratory alarm-endowed device. When emitted without warning, the alarms were sensed by 72.4% of patients. When patients were forewarned, the probability of sensing the alarms rose to 92.5% (P < 0.001). In both cases, the vibratory alarm was more likely to be sensed than the audible alert (77.3 vs. 67.7% in the first case; 96.1 vs. 87.9% in the second case; all P < 0.05). CONCLUSION: ICD alarms emitted in an outpatient setting are sensed by a large proportion of patients, but not by all. Training patients by means of demonstration tests significantly increases the rate of patients who recognize the alarm. Vibratory alarm seems to be more effective than audible alert.