RESUMO
Objective: This study aimed to assess the relationship between chemerin and visfatin concentrations and insulin resistance in Saudi women with hyperthyroidism. Materials and Methods: Seventy healthy participants and 70 participants with hyperthyroidism were recruited for the study. Concentrations of chemerin, visfatin, thyroid profile, fasting glucose, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) were measured. Results: Hyperthyroid patients showed significantly higher concentrations of fasting glucose and insulin (P < 0.001) and significant increases in HOMA-IR values than the control group. Spearman's correlation coefficient analysis showed that thyroid-stimulating hormone was negatively correlated with glucose, insulin, and HOMA-IR, while free triiodothyronine was positively correlated with the same parameters. Total triiodothyronine and total thyroxine also showed a significant positive correlation with glucose, and the levels of thyroglobulin were also positively correlated with insulin and HOMA-IR. Furthermore, chemerin levels correlated positively with glucose, insulin, and HOMA-IR. Inversely, visfatin was negatively correlated with insulin and HOMA-IR. Conclusion: A significant relationship was observed between adipokines and thyroid profile, glucose, insulin, and insulin resistance in hyperthyroid patients. This suggests that visfatin and chemerin levels might affect insulin sensitivity in conjunction with thyroid hormones and thus may alter the metabolism of glucose and leads to insulin resistance.
RESUMO
Objectives: The aim of this study was to investigate the potential influence of hyperthyroidism on serum chemerin, visfatin, and omentin concentrations. The relationship between these adipokines and thyroid profile values was also investigated. Methods: A total of 140 female Saudi participants aged 20-45 years were recruited and divided into two groups, the euthyroid control group (n = 70) and the hyperthyroidism group (n = 70). Chemerin, visfatin, omentin, and thyroid profile including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), and thyroglobulin were measured for all participants. Results: Serum chemerin levels were significantly higher in patients with hyperthyroidism compared to the controls. In contrast, serum visfatin and omentin concentrations were significantly lower in hyperthyroid patients than controls. Moreover, serum chemerin concentrations were positively correlated with TT3, TT4, and FT3 and negatively correlated with TSH and FT4. A negative correlation was also found between FT4 and TT4 and serum visfatin concentrations. Inversely, TSH correlated positively with serum visfatin levels. No significant correlation was observed between serum omentin concentrations and any of the thyroid profile variables except FT3. Conclusion: Hyperthyroidism influences serum chemerin, visfatin, and omentin concentrations, and these adipokines are correlated with thyroid hormones.
