RESUMO
An mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection. Most cases of mpox in sold organ transplant (SOT) recipients reported in the literature were treated with tecovirimat. Here we report two cases of severe disseminated mpox infection in renal transplant recipients that were successfully treated with brincidofovir. Both patients were discharged from the hospital with no immediate significant side effects from brincidofovir reported until the submission of this report.
Assuntos
Antivirais , Citosina , Citosina/análogos & derivados , Hospedeiro Imunocomprometido , Transplante de Rim , Organofosfonatos , Humanos , Transplante de Rim/efeitos adversos , Antivirais/uso terapêutico , Citosina/uso terapêutico , Masculino , Organofosfonatos/uso terapêutico , Adulto , Transplantados , Resultado do Tratamento , Pessoa de Meia-IdadeRESUMO
Aspergillus endocarditis is a rare infection that occurs most commonly in patients with prior cardiac surgery but cases in post-transplant recipients without prior cardiac surgery have been reported. Diagnosis is often delayed and requires high index of suspicion. We here report a case of Aspergillus endocarditis in solid organ transplant recipient.
Assuntos
Aspergilose/microbiologia , Aspergillus flavus/isolamento & purificação , Endocardite/microbiologia , Transplante de Rim/efeitos adversos , Transplante de Fígado/efeitos adversos , Aspergilose/diagnóstico por imagem , Aspergilose/patologia , Aspergilose/cirurgia , Ecocardiografia Transesofagiana , Endocardite/diagnóstico por imagem , Endocardite/patologia , Endocardite/cirurgia , Feminino , Rejeição de Enxerto/prevenção & controle , Valvas Cardíacas/microbiologia , Valvas Cardíacas/patologia , Valvas Cardíacas/cirurgia , Humanos , Imunossupressores/efeitos adversos , Pessoa de Meia-IdadeRESUMO
Herein, we report a case of a 27-year-old man with Ebstein's anomaly and a history of unexplained recurrent venous thrombosis despite adequate anticoagulation. After surgical correction of the Ebstein's anomaly, the venous thromboembolic events did not recur. This case demonstrates the possible etiopathogenesis of Ebstein's anomaly in causing recurrent venous thromboembolism, which is likely caused through impedance of venous blood flow.Our objective in presenting this particular case is to highlight the possible association between Ebstein's anomaly and venous thrombosis.