RESUMO
The relative bioavailability of the vasodilator naftidrofuryl from formulations containing its oxalate or citrate salt has been estimated using a specific HPLC assay, and a less specific fluorimetric assay, to measure plasma drug concentrations. The conclusions of the study were the same irrespective of the assay employed. The relative rate, but not the extent, of bioavailability of naftidrofuryl from the citrate salt (peak 1096 ng ml-1 at 0.76 h) was marginally greater (p = 0.003) than that from the oxalate salt (peak 922 ng ml-1 at 0.94 h). The degree of intersubject variability was similar after administration of either salt form. The mean half-life of naftidrofuryl was 1.8 h and its mean residence time was 2.5 h.
Assuntos
Furanos/sangue , Nafronil/sangue , Adulto , Disponibilidade Biológica , Cromatografia Líquida de Alta Pressão/métodos , Humanos , Cinética , Masculino , Espectrometria de Fluorescência/métodosRESUMO
Thirty-three patients with Crohn's Disease were studied to see if their symptoms were related to food intolerances. Initial treatment to produce remission of symptoms was total parenteral nutrition (20), elemental diet (2) or elimination diet (11). Twenty-nine patients reported specific food intolerances, and 21 of these remained in remission on diet alone, the mean length of remission being 15.2 months. The most important foods provoking symptoms were wheat and dairy products.