1.
RSC Chem Biol
; 3(4): 420-425, 2022 Apr 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35441142
RESUMO
Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.