Prophylactic therapy with valganciclovir in high-risk (cytomegalovirus D+/R-) kidney transplant recipients: a single-center experience.

BACKGROUND: A prospective study was performed in kidney transplant patients at risk of developing cytomegalovirus (CMV) infection (CMV D+/R-). They were treated with valganciclovir (VGC) for 3 months as prophylactic therapy. The aim was to determine the safety and efficacy of prophylactic therapy with VGC. METHODS: Antigenemia and/or polymerase chain reaction CMV was routinely performed every 2 weeks up to month 3, monthly to month 6, and every other month until the end of the first year posttranplantation, as well as when clinically indicated. RESULTS: From July 2007 to April 2010, 366 renal transplantations were performed at our center, including 34 (9%) high-risk patients for CMV infection. The median age was 47 years; 19 were males and 15 females. Twelve (35%) patients developed CMV infections: 10 (34%) gastrointestinal disease and 3 viral syndromes. The timing of the clinical manifestations was 16% (3/12) between months 1 and 3, 75% (8/12) between months 4 and 6, and 8% (1/12) in month 9 posttransplantation. CONCLUSION: Treatment with intravenous ganciclovir followed by oral VGC was successful in all patients. No opportunistic infections or allograft rejection were observed; only 1 patient developed thrombocytopenia as an adverse event to VGC.

[Herpes simplex virus encephalitis in a renal transplant patient]. / Encefalitis por virus herpes simple en paciente portadora de trasplante renal. Estudio de un caso y revisión de la literatura.

The incidence of herpes simplex virus (HSV) encephalitis is estimated to occur annually in 2-4 cases per million population. HSV encephalitis is exceptional in renal transplant patients, we have found two previous reports after an extensive bibliography search. We report a case of a 47 years old women renal transplant recipient who presented 3 months after transplantation fever, stupor and aphasia. The diagnosis HSV encephalitis was achieved by PCR in cerebrospinal fluid and magnetic resonance imaging. She was treated with aciclovir for 4 weeks and recovered completely without neurologic sequelae.

Encefalitis por virus herpes simple en paciente portadora de trasplante renal. Estudio de un caso y revisión de la literatura / Herpes simplex virus encephalitis in a renal transplant patient

La incidencia estimada de encefalitis por virus herpes simple (VHS) es de 2-4casos anuales por millón de población general. La encefalitis por VHS en pacientestrasplantados es una complicación muy poco frecuente, de la que sólo hemosencontrado dos citas en la revisión bibliográfica realizada.Presentamos el caso de una paciente de 47 años que a los 3 meses del trasplanterenal presentó un cuadro de fiebre, estupor y afasia debido a una encefalitispor VHS. El diagnóstico se realizó mediante PCR en líquido cefalorraquídeoy resonancia magnética cerebral. La paciente fue tratada con aciclovir, recuperándosesin secuelas clínicas

The incidence of herpes simplex virus (HSV) encephalitis is estimated to occurannually in 2-4 cases per million population. HSV encephalitis is exceptional inrenal transplant patients, we have found two previous reports after an extensivebibliography search.We report a case of a 47 years old women renal transplant recipient who presented3 months after transplantation fever, stupor and aphasia. The diagnosis HSVencephalitis was achieved by PCR in cerebrospinal fluid and magnetic resonanceimaging. She was treated with aciclovir for 4 weeks and recovered completely withoutneurologic sequelae

Nefrología basada en investigación clínica: bases conceptuales para la constitución de un grupo de trabajo en Nefrología Basada en la Evidencia de la Sociedad Española de Nefrología / No disponible

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Encefalitis por virus herpes simple en paciente portadora de trasplante renal. Estudio de un caso y revisión de la literatura / Herpes simplex virus encephalitis in a renal transplant patient

La incidencia estimada de encefalitis por virus herpes simple (VHS) es de 2-4casos anuales por millón de población general. La encefalitis por VHS en pacientestrasplantados es una complicación muy poco frecuente, de la que sólo hemosencontrado dos citas en la revisión bibliográfica realizada.Presentamos el caso de una paciente de 47 años que a los 3 meses del trasplanterenal presentó un cuadro de fiebre, estupor y afasia debido a una encefalitispor VHS. El diagnóstico se realizó mediante PCR en líquido cefalorraquídeoy resonancia magnética cerebral. La paciente fue tratada con aciclovir, recuperándosesin secuelas clínicas

The incidence of herpes simplex virus (HSV) encephalitis is estimated to occurannually in 2-4 cases per million population. HSV encephalitis is exceptional inrenal transplant patients, we have found two previous reports after an extensivebibliography search.We report a case of a 47 years old women renal transplant recipient who presented3 months after transplantation fever, stupor and aphasia. The diagnosis HSVencephalitis was achieved by PCR in cerebrospinal fluid and magnetic resonanceimaging. She was treated with aciclovir for 4 weeks and recovered completely withoutneurologic sequelae

Safety and efficacy of tacrolimus rescue therapy in 55 kidney transplant patients treated with cyclosporine.

To evaluate the efficacy and safety of conversion from cyclosporine to tacrolimus, we analyzed 55 kidney transplant patients who were converted due to cosmetic reasons in 42 patients, acute rejection in 2 patients, and other causes in 11 patients. At the doses and levels used, the development of diabetes mellitus was minimized. Disappearance of cosmetic side-effects and improvement of cardiovascular risk factors, together with conservation of renal function, encourage us to use tacrolimus as an efficacious and safe immunosuppressive therapy.

Case Reports. Infection due to Scedosporium apiospermum in renal transplant recipients: a report of two cases and literature review of central nervous system and cutaneous infections by Pseudallescheria boydii/Sc. apiospermum.

Two cases of infections due to Scedosporium apiospermum in renal transplant recipients, one localized in the central nervous system, the other in the skin, are presented, and a literature review of 21 cases of central nervous system and cutaneous infections due to Pseudallescheria boydii/Sc. apiospermum is given.

Registros sanitarios, una necesidad actual / The need of sanitary registries

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Informe de diálisis y trasplante de la sociedad española de nefrología y registros autonómicos correspondientes al año 1999 / Dyalisis and transplant registry of the Spanish Society of Nephrology

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