[The health and nutrition of indigenous children in Chile (Mapuche)]. / Salud y nutrición del niño indígena chileno (Mapuche).

The aim of this study was to conduct a review of the health and nutritional status of Chilean indigenous children, specifically Mapuche children, as published in the literature and specific population-based studies. The searches were conducted in PubMed and LILACS in the last 15 years. From 2006 to 2015, the poverty rate was higher in the indigenous population, with a decrease in the gap from 16% in 2006 to 7.7% in 2015 (p < 0.001). In the first decade of this century, infant mortality in indigenous children was 17.1/1,000 live births, while in non-indigenous children it was 8.8/1,000, and the gap was maintained in the five-year follow-up (p < 0.001). Newborns with birthweight < 2,500g in the year 2000 did not reach 6% (5.6% in non-indigenous and 5.2% in indigenous children). Low height at first school enrollment was 8.4% in indigenous schoolchildren and 3.1% in non-indigenous children, decreasing to 3.7% in indigenous children and 2.6% in non-indigenous children in 2004, while obesity increased more in indigenous children, reaching 24.2% in indigenous and 25.3% in non-indigenous children (p < 0.001). Menarche appeared four months later on average in indigenous girls (12.7 years), and body mass index, waist circumference, and fat mass were significantly greater in indigenous girls at the time of thelarche, as was the overweight rate (55%, vs. 42% in non-indigenous). Mapuche children show favorable health and nutritional status compared to indigenous children elsewhere in Latin America, but there is still an adverse gap compared to non-indigenous Chilean children. This inequality affecting indigenous Chilean children should be acknowledged and corrected.

El objetivo de este trabajo fue realizar una revisión de la situación de salud y nutrición del niño indígena chileno, específicamente del Mapuche, en lo publicado en las bases de datos de referencias bibliográficas y en investigaciones específicas que tienen base poblacional. Para este trabajo se buscó lo publicado en PubMed, LILACS, organismos nacionales e internacionales, durante los últimos 15 años. Desde el 2006 hasta el 2015 la proporción de pobres era mayor en los indígenas, con disminución de la brecha de 16% el 2006 a 7,7% el 2015 (p < 0,001). En la primera década de este siglo la mortalidad infantil en los niños indígenas tenía una tasa de 17,1/1.000 nacidos vivos, mientras en los no indígenas era de de 8,8/1.000 y, en el seguimiento de cinco años, la brecha se mantuvo (p < 0,001). Los recién nacidos con peso < 2,500g el año 2000 no superaban el 6% (5,6% en no indígenas y 5,2% en los indígenas). La talla baja al ingreso a la escuela era 8,4% en los escolares indígenas y 3,1% en los no indígenas, disminuyendo a 3,7 en los indígenas y 2,6% en los no indígenas el 2004, la obesidad en cambio aumentó más en los indígenas, llegando a 24,2 y 25,3% en los no indígenas (p < 0,001). La menarquia se presentó cuatro meses más tarde en las indígenas (12,7 años) y el índice de masa corporal, circunferencia de cintura y el porcentaje de grasa, fueron significativamente mayores en las indígenas en el momento de la telarquia, así como la frecuencia de exceso de peso (55% vs. 42% en las no indígenas). Los niños Mapuche presentan una condición de salud y nutrición favorable, comparada con los indígenas de otros países del continente, sin embargo, aun existe una brecha adversa -comparada con los no indígenas-, en que la desigualdad desfavorece al niño indígena y esta debe ser reconocida y corregida.

O objetivo deste trabalho foi realizar una revisão da situação da saúde e nutrição da criança indígena chilena, especificamente da Mapuche, nas publicações relacionadas em bases de dados de referências bibliográficas e em pesquisas específicas que têm base populacional. A pesquisa foi realizada em publicações relacionadas: PubMed, LILACS, organismos nacionais e internacionais, nos últimos 15 anos. Desde 2006 até 2015 a proporção de pobres era maior nos indígenas, com diminuição de uma diferença de 16% em 2006 a 7,7% em 2015 (p < 0.001). Na primeira década de este século a mortalidade infantil nas crianças indígenas teve una taxa de 17,1/1.000 nascidas vivas, enquanto nos não indígenas era de 8,8/1.000 e, em um acompanhamento de cinco anos, a diferença se manteve (p < 0,001). Os recém-nascidos com peso < 2.500g no ano de 2000 não superavam 6% (5,6% em não indígenas e 5,2% nos indígenas). A baixa estatura ao momento do ingresso na escola era 8,4% nos escolares indígenas e 3,1% nos não indígenas, diminuindo a 3,7 nos indígenas e 2,6% nos não indígenas em 2004, a obesidade pelo contrário teve um aumento maior nos indígenas, chegando a 24,2 e 25,3% nos não indígenas (p < 0,001). A menarca ocorreu quatro meses mais tarde nas indígenas (12,7 anos) e o índice de massa corporal, circunferência da cintura e a porcentagem da gordura, foram significativamente maiores nas indígenas no período da telarca, à semelhança da frequência do sobrepeso (55% vs. 42% nas não indígenas). As crianças Mapuche apresentam uma condição de saúde e nutrição favorável, comparada com os indígenas de outros países do continente, no entanto, ainda existe uma brecha adversa - comparada com os não indígenas - , onde a desigualdade desfavorece a criança indígena e por isso deve ser reconhecida e corrigida.

Bebidas endulzadas en adultos jóvenes y su asociación con adiposidad y riesgo metabólico / Sweetened beverages in young adults and its association to adiposity and metabolic risk

Resumen: Objetivo: Estimar la asociación entre consumo de bebidas endulzadas (BE) con indicadores de adiposidad y riesgo metabólico en adultos jóvenes. Material y métodos: Se analizó la frecuencia de consumo de alimentos, índice de masa corporal (IMC), circunferencia de cintura (CC), grasa corporal (PGC), glicemia y triglicéridos de 931 participantes seleccionados aleatoriamente (Región de Valparaíso, Chile), mediante modelos de regresión múltiple, controlando factores de confusión. Resultados: La mediana de edad fue 24.9 años; 94% (IC95% :92.3-95.3) de los participantes consumía BE, 33.1% de ellos consumía más de dos porciones (≥500 ml) diarias, que se asoció con incremento en glicemia (ambos sexos) (β=2.17; p=0.007) y con IMC (β=1.48, p=0.04), CC (β=4.50; p=0.009) y PGC (β=3.02; p<0.001) sólo en mujeres. Conclusión: La alta ingesta de BE incrementa la glicemia en adultos jóvenes y los indicadores de adiposidad en mujeres, antecedentes relevantes para formular políticas que disminuyan el consumo de BE y sus consecuencias.

Abstract: Objective: To estimate the association between sweetened beverages (SB) consumption with adiposity indicators and metabolic status among young Chilean adults. Materials and methods: We analyzed food frequency consumption, body mass index (BMC), waist circumference (WC), body fat percentage (BFP), glucose and triglycerides in 931 young adults randomly selected from Valparaiso Region using multivariate regression models controlling confusion and interactions factors. Results: The median age was 24.9 years; (95%CI: 92.3-95.3) reported SB consumption, 33.1% received more than two portions (≥500 ml) daily what was associated with an increase in glycemia (β=2.40; p=0.024) (both sexes), with BMI (β=1.48, p=0.04), WC (β= 4.50; p=0.009) and BFP (β=3.02, p< 0.001) only in women. Conclusion: High consumption of SB increases glycemia in young adults and only in women, indicators of adiposity, relevant antecedents to formulate policies that decrease SB consumption and its consequences.

[Sweetened beverages in young adults and its association to adiposity and metabolic risk]. / Bebidas endulzadas en adultos jóvenes y su asociación con adiposidad y riesgo metabólico.

OBJECTIVE: To estimate the association between sweetened beverages (SB) consumption with adiposity indicators and metabolic status among young Chilean adults. MATERIALS AND METHODS: We analyzed food frequency consumption, body mass index (BMC), waist circumference (WC), body fat percentage (BFP), glucose and triglycerides in 931 young adults randomly selected from Valparaiso Region using multivariate regression models controlling confusion and interactions factors. RESULTS: The median age was 24.9 years; (95%CI: 92.3-95.3) reported SB consumption, 33.1% received more than two portions (≥500 ml) daily what was associated with an increase in glycemia (ß=2.40; p=0.024) (both sexes), with BMI (ß=1.48, p=0.04), WC (ß= 4.50; p=0.009) and BFP (ß=3.02, p< 0.001) only in women. CONCLUSIONS: High consumption of SB increases glycemia in young adults and only in women, indicators of adiposity, relevant antecedents to formulate policies that decrease SB consumption and its consequences.

OBJECTIVE: Estimar la asociación entre consumo de bebidas endulzadas (BE) con indicadores de adiposidad y riesgo metabólico en adultos jóvenes. MATERIALS AND METHODS: Se analizó la frecuencia de consumo de alimentos, índice de masa corporal (IMC), circunferencia de cintura (CC), grasa corporal (PGC), glicemia y triglicéridos de 931 participantes seleccionados aleatoriamente (Región de Valparaíso, Chile), mediante modelos de regresión múltiple, controlando factores de confusión. RESULTS: La mediana de edad fue 24.9 años; 94% (IC95% :92.3-95.3) de los participantes consumía BE, 33.1% de ellos consumía más de dos porciones (≥500 ml) diarias, que se asoció con incremento en glicemia (ambos sexos) (ß=2.17; p=0.007) y con IMC (ß=1.48, p=0.04), CC(ß=4.50; p=0.009) y PGC (ß=3.02; p<0.001) sólo en mujeres. CONCLUSIONS: La alta ingesta de BE incrementa la glicemia en adultos jóvenes y los indicadores de adiposidad en mujeres, antecedentes relevantes para formular políticas que disminuyan el consumo de BE y sus consecuencias.

Salud y nutrición del niño indígena chileno (Mapuche) / The health and nutrition of indigenous children in Chile (Mapuche) / Saúde e nutrição da criança indígena chilena (Mapuche)

El objetivo de este trabajo fue realizar una revisión de la situación de salud y nutrición del niño indígena chileno, específicamente del Mapuche, en lo publicado en las bases de datos de referencias bibliográficas y en investigaciones específicas que tienen base poblacional. Para este trabajo se buscó lo publicado en PubMed, LILACS, organismos nacionales e internacionales, durante los últimos 15 años. Desde el 2006 hasta el 2015 la proporción de pobres era mayor en los indígenas, con disminución de la brecha de 16% el 2006 a 7,7% el 2015 (p < 0,001). En la primera década de este siglo la mortalidad infantil en los niños indígenas tenía una tasa de 17,1/1.000 nacidos vivos, mientras en los no indígenas era de de 8,8/1.000 y, en el seguimiento de cinco años, la brecha se mantuvo (p < 0,001). Los recién nacidos con peso < 2,500g el año 2000 no superaban el 6% (5,6% en no indígenas y 5,2% en los indígenas). La talla baja al ingreso a la escuela era 8,4% en los escolares indígenas y 3,1% en los no indígenas, disminuyendo a 3,7 en los indígenas y 2,6% en los no indígenas el 2004, la obesidad en cambio aumentó más en los indígenas, llegando a 24,2 y 25,3% en los no indígenas (p < 0,001). La menarquia se presentó cuatro meses más tarde en las indígenas (12,7 años) y el índice de masa corporal, circunferencia de cintura y el porcentaje de grasa, fueron significativamente mayores en las indígenas en el momento de la telarquia, así como la frecuencia de exceso de peso (55% vs. 42% en las no indígenas). Los niños Mapuche presentan una condición de salud y nutrición favorable, comparada con los indígenas de otros países del continente, sin embargo, aun existe una brecha adversa -comparada con los no indígenas-, en que la desigualdad desfavorece al niño indígena y esta debe ser reconocida y corregida.

The aim of this study was to conduct a review of the health and nutritional status of Chilean indigenous children, specifically Mapuche children, as published in the literature and specific population-based studies. The searches were conducted in PubMed and LILACS in the last 15 years. From 2006 to 2015, the poverty rate was higher in the indigenous population, with a decrease in the gap from 16% in 2006 to 7.7% in 2015 (p < 0.001). In the first decade of this century, infant mortality in indigenous children was 17.1/1,000 live births, while in non-indigenous children it was 8.8/1,000, and the gap was maintained in the five-year follow-up (p < 0.001). Newborns with birthweight < 2,500g in the year 2000 did not reach 6% (5.6% in non-indigenous and 5.2% in indigenous children). Low height at first school enrollment was 8.4% in indigenous schoolchildren and 3.1% in non-indigenous children, decreasing to 3.7% in indigenous children and 2.6% in non-indigenous children in 2004, while obesity increased more in indigenous children, reaching 24.2% in indigenous and 25.3% in non-indigenous children (p < 0.001). Menarche appeared four months later on average in indigenous girls (12.7 years), and body mass index, waist circumference, and fat mass were significantly greater in indigenous girls at the time of thelarche, as was the overweight rate (55%, vs. 42% in non-indigenous). Mapuche children show favorable health and nutritional status compared to indigenous children elsewhere in Latin America, but there is still an adverse gap compared to non-indigenous Chilean children. This inequality affecting indigenous Chilean children should be acknowledged and corrected.

O objetivo deste trabalho foi realizar una revisão da situação da saúde e nutrição da criança indígena chilena, especificamente da Mapuche, nas publicações relacionadas em bases de dados de referências bibliográficas e em pesquisas específicas que têm base populacional. A pesquisa foi realizada em publicações relacionadas: PubMed, LILACS, organismos nacionais e internacionais, nos últimos 15 anos. Desde 2006 até 2015 a proporção de pobres era maior nos indígenas, com diminuição de uma diferença de 16% em 2006 a 7,7% em 2015 (p < 0.001). Na primeira década de este século a mortalidade infantil nas crianças indígenas teve una taxa de 17,1/1.000 nascidas vivas, enquanto nos não indígenas era de 8,8/1.000 e, em um acompanhamento de cinco anos, a diferença se manteve (p < 0,001). Os recém-nascidos com peso < 2.500g no ano de 2000 não superavam 6% (5,6% em não indígenas e 5,2% nos indígenas). A baixa estatura ao momento do ingresso na escola era 8,4% nos escolares indígenas e 3,1% nos não indígenas, diminuindo a 3,7 nos indígenas e 2,6% nos não indígenas em 2004, a obesidade pelo contrário teve um aumento maior nos indígenas, chegando a 24,2 e 25,3% nos não indígenas (p < 0,001). A menarca ocorreu quatro meses mais tarde nas indígenas (12,7 anos) e o índice de massa corporal, circunferência da cintura e a porcentagem da gordura, foram significativamente maiores nas indígenas no período da telarca, à semelhança da frequência do sobrepeso (55% vs. 42% nas não indígenas). As crianças Mapuche apresentam uma condição de saúde e nutrição favorável, comparada com os indígenas de outros países do continente, no entanto, ainda existe uma brecha adversa - comparada com os não indígenas - , onde a desigualdade desfavorece a criança indígena e por isso deve ser reconhecida e corrigida.

Ethnic group inequalities in coverage with reproductive, maternal and child health interventions: cross-sectional analyses of national surveys in 16 Latin American and Caribbean countries.

BACKGROUND: Latin American and Caribbean populations include three main ethnic groups: indigenous people, people of African descent, and people of European descent. We investigated ethnic inequalities among these groups in population coverage with reproductive, maternal, newborn, and child health interventions. METHODS: We analysed 16 standardised, nationally representative surveys carried out from 2004 to 2015 in Latin America and the Caribbean that provided information on ethnicity or a proxy indicator (household language or skin colour) and on coverage of reproductive, maternal, newborn, and child health interventions. We selected four outcomes: coverage with modern contraception, antenatal care coverage (defined as four or more antenatal visits), and skilled attendants at birth for women aged 15-49 years; and coverage with three doses of diphtheria-pertussis-tetanus (DPT3) vaccine among children aged 12-23 months. We classified women and children as indigenous, of African descent, or other ancestry (reference group) on the basis of their self-reported ethnicity or language. Mediating variables included wealth quintiles (based on household asset indices), woman's education, and urban-rural residence. We calculated crude and adjusted coverage ratios using Poisson regression. FINDINGS: Ethnic gaps in coverage varied substantially from country to country. In most countries, coverage with modern contraception (median coverage ratio 0·82, IQR 0·66-0·92), antenatal care (0·86, 0·75-0·94), and skilled birth attendants (0·75, 0·68-0·92) was lower among indigenous women than in the reference group. Only three countries (Nicaragua, Panama, and Paraguay) showed significant gaps in DPT3 coverage between the indigenous and the reference groups. The differences were attenuated but persisted after adjustment for wealth, education, and residence. Women and children of African descent showed similar coverage to the reference group in most countries. INTERPRETATION: The lower coverage levels for indigenous women are pervasive, and cannot be explained solely by differences in wealth, education, or residence. Interventions delivered at community level-such as vaccines-show less inequality than those requiring access to services, such as birth attendance. Regular monitoring of ethnic inequalities is essential to evaluate existing initiatives aimed at the inclusion of minorities and to plan effective multisectoral policies and programmes. FUNDING: The Bill & Melinda Gates Foundation (through the Countdown to 2030 initiative) and the Wellcome Trust.

[Pattern of smoking and socioeconomic status in two cohorts of young adults]. / Patrón de tabaquismo y nivel socioeconómico en dos cohortes de adultos jóvenes.

BACKGROUND: One in five deaths that occur in Chile can be attributed to smoking whose prevalence remains high, despite interventions aimed at reducing it. AIM: To compare the prevalence of smoking and its intensity among young adults born 15 years apart and determine their association with socioeconomic status (SES). MATERIAL AND METHODS: Two cohorts of young adults living in the Valparaiso Region of Chile were evaluated in the third decade of life. Cohort 1 was evaluated between 2000 and 2002 (n = 1232) and cohort 2 between 2014 and 2017 (n = 1078). RESULTS: In cohort 1, 57.5% (95% Confidence Interval (CI) 54.6-58.7) of the subjects reported smoking, with a median of 3 (Interquartile range (ICR:1-6) cigarettes/day. This percentage fell to 40.2% (CI: 37.5-43.1) with a similar median in cohort 2. Analyzing cohort 2, the odds ratio (OR) for smoking was 2.24 (CI 1.48-3.38) in the medium SES, compared with the medium high SES. The figures for low medium and low SES were 2.72 (CI: 1.85-3.99) and 3.01 (1.85-4.88). Similarly, in this cohort there was a significantly higher risk of being a heavy smoker in lower SES. No associations between smoking or its intensity and SES were observed in cohort 1. CONCLUSIONS: Smoking behavior has decreased among young adults evaluated at the same age in two generational cohorts in the third decade of life. In the most recent cohort analyzed, smoking and its intensity increase along with a decrease in SES.

Changes in socio-economic level and their impact on nutritional status: a follow-up study among young Chilean adults.

OBJECTIVE: To verify the association between changes in socio-economic level (SEL) and nutritional status of Chilean adults over a 10-year period. DESIGN: Concurrent cohort study.Setting/SubjectsIndividuals born from 1974 to 1978 in the Valparaíso Region of Chile were evaluated between 2000 and 2002 (n 1232) and again between 2010 and 2012 (n 796). SEL was characterized according to the occupation and educational level of the head of household. Nutritional status was based on measurement of BMI and waist circumference (WC). RESULTS: Between the first and second evaluation there was a 13 % reduction in the number of individuals classified as poor and a 12 % increase in those classified in the medium high SEL. Increases in BMI were found among women who remained in the low SEL (ß=2·2, 95 % CI 0·16, 2·87) compared with women who maintained the same SEL (and whose SEL was above low over the 10-year period). Women who remained in the low SEL increased their WC (ß=4·10, 95 % CI 0·27, 7·93). There were no associations between nutritional status and SEL among males. CONCLUSIONS: In the period studied, the SEL of the study population improved between the third and fourth decade of life, but BMI and WC also increased among women, with the lowest socio-economic group experiencing the greatest changes. Meanwhile, among males we found no association between anthropometric measurements and changes in SEL.

Patrón de tabaquismo y nivel socioeconómico en dos cohortes de adultos jóvenes / Pattern of smoking and socioeconomic status in two cohorts of young adults

Background: One in five deaths that occur in Chile can be attributed to smoking whose prevalence remains high, despite interventions aimed at reducing it. Aim: To compare the prevalence of smoking and its intensity among young adults born 15 years apart and determine their association with socioeconomic status (SES). Material and Methods: Two cohorts of young adults living in the Valparaiso Region of Chile were evaluated in the third decade of life. Cohort 1 was evaluated between 2000 and 2002 (n = 1232) and cohort 2 between 2014 and 2017 (n = 1078). Results: In cohort 1, 57.5% (95% Confidence Interval (CI) 54.6-58.7) of the subjects reported smoking, with a median of 3 (Interquartile range (ICR:1-6) cigarettes/day. This percentage fell to 40.2% (CI: 37.5-43.1) with a similar median in cohort 2. Analyzing cohort 2, the odds ratio (OR) for smoking was 2.24 (CI 1.48-3.38) in the medium SES, compared with the medium high SES. The figures for low medium and low SES were 2.72 (CI: 1.85-3.99) and 3.01 (1.85-4.88). Similarly, in this cohort there was a significantly higher risk of being a heavy smoker in lower SES. No associations between smoking or its intensity and SES were observed in cohort 1. Conclusions: Smoking behavior has decreased among young adults evaluated at the same age in two generational cohorts in the third decade of life. In the most recent cohort analyzed, smoking and its intensity increase along with a decrease in SES.

Change in postmenarche anthropometric indicators in indigenous and nonindigenous adolescents from Chile.

OBJECTIVE: To analyze the change in anthropometric indicators between menarche and 36 months after menarche among indigenous and non-indigenous adolescents from the Araucanía Region of Chile. METHOD: This was a concurrent cohort study. Of 8,504 girls interviewed, 114 indigenous adolescents and 123 nonindigenous adolescents who had recently experienced menarche were selected. Body mass index (BMI), BMI by age (BMI z-score), waist circumference (WC) and body fat percentage (BF%) were evaluated at menarche and 6, 12, 18, 24, 30, and 36 months postmenarche. Linear models estimated with generalized estimating equations were used to quantify disparities adjusted for baseline anthropometric values, age at menarche, place of residence, and socioeconomic level. RESULTS: Indigenous girls presented menarche 4 months later than nonindigenous girls and had significantly higher BMI (1.5 kg/m2 ), BMI z-score (0.4), WC (2.9 cm), and BF% (1.7%) at menarche. Adjusted results did not show an association between being indigenous and post-menarche anthropometric variables: BMI = 0.1 kg/m2 (CI = -0.3; 0.5), BMI z-score = 0 (CI = -0.1; 0.1), WC = 0.7 cm (CI = -0.6; 2.0), and BF% = 0.5% (CI = -0.2; 1.3). It is important to mention that the mean BMI z-score of both groups were in the overweight category. CONCLUSION: At menarche, indigenous girls had higher values than nonindigenous girls for all anthropometric variables, and this trend remained after menarche, with no further change in ethnic disparity over the subsequent three years. This reinforces the need to implement interventions to prevent or control excess weight prior to menarche, with emphasis on indigenous girls.

Índice, carga glicémica y fibra dietética de los alimentos y su asociación con resistencia a la insulina en adultos chilenos / Glycemic index, glycemic load and dietary fiber of foods and its association with insulin resistance in Chilean adults

El Índice y Carga Glicémica (IG y CG) categorizan los alimentos según su capacidad de incrementar la glicemia, considerando cantidad y calidad de hidratos de carbono consumidos. Diferentes estudios han postulado que una dieta con IG y CG altos y bajo consumo de fibra incrementan la glicemia e insulinemia, aunque con resultados heterogéneos.El objetivo de este estudio fue analizar la asociación entre IG, CG e ingesta de fibra y valores HOMA-IR en adultos jóvenes. En una muestra representativa de 738 personas que tenían entre 32 y 38 años, nacidos en el Hospital de Limache, Región de Valparaíso, Chile, se recogió información socioeconómica, de salud, se determinó estado nutricional, glicemia, insulina basal y HOMA, y con la encuesta de frecuencia de consumo se estimó IG, CG e ingesta de fibra. Se construyeron modelos de regresión múltiple, controlando efectos de confusión e interacción. En modelos ajustados, se observó que por cada 10 unidades que aumenta el IG y CG de la dieta en individuos con exceso de peso, aumenta el HOMA-IR en 0,31 (p=0,042) y 0,03 (p=0,012), respectivamente y por cada 10 gramos que aumenta la fibra total y soluble, disminuye el HOMA-IR en 0,10 (p=0,04) y 0,62 (p=0,034) respectivamente. En personas sin exceso de peso no hubo estos efectos. Existe una asociación directa entre el aumento de IG y CG de los alimentos y el incremento de HOMA-IR sólo en individuos con exceso de peso y una asociación inversa entre ingesta de fibra dietética total y soluble y HOMA-IR(AU)

Glycemic index, glycemic load and dietary fiber of foods and its association with insulin resistance in Chilean adults. Glycemic index and glycemic load (GI and GL) categorize foods according to their ability to increase blood sugar levels, considering quantity and quality of carbohydrates consumed. Different studies have postulated that a high GI and GL diet and low fiber intake increased glycemia and insulinemia, although with heterogeneous results. The aim of this study was to analyze the association between GI, GL and fiber intake and HOMA-IR values in young adults. In a representative sample of 738 people aged between 32 and 38 years old, born in the Limache’s Hospital, Valparaiso, Chile, socioeconomic and health information, nutritional status, basal glycemia, insulin and HOMA were collected. With a food frequency questionnaire, GI, GL and fiber intake were estimated. Multiple regression models were constructed, controlling confounding and interaction effects. In adjusted models, it was found that for every 10 units that increases diet GI and GL in overweight individuals, HOMA- IR increases in 0.31 (p = 0.042) and 0.03 (p = 0.012) respectively, and for every 10 grams that increases total and soluble fiber intake, HOMA-IR reduces in 0.10 (p = 0.04) and 0.62 (p = 0.034) respectively. In people without overweight such effects were not observed. There was a direct association bet- ween increased GI and GL foods and increased HOMA-IR only in individuals with overweight and an inverse association between total and soluble fiber intake and HOMA-IR(AU)

Síndrome metabólico e inflamación en adultos: un estudio poblacional / Association of C reactive protein levels with metabolic syndrome in adults: a population-based study

Background: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. Aim: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. Material and Methods: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP. This parameter was classified as normal for values from 0 to 3 mg/L, high for values from 3.01 to 10 mg/L and very high for values > 10 mg/L. Results: Median CRP was in the normal range (1.9 mg/L, interquartile range 0.7-5.2) and was higher among women than men (2.2 and 1.4 mg/L respectively, p < 0.01). Twenty seven percent of participants had MetS. One-fourth had high blood glucose values, one-third had high triglyceride levels and 28% had blood pressure values over those established as normal in MetS. Elevated waist circumference (WC) and low HDL cholesterol were found among almost 50% of participants. A relationship between MetS and high CRP was only found among men with an Odds ratio (OR) of 2.04 (95% confidence intervals (CI): 1.11-3.73). The same association was observed for high triglyceride levels with an OR of 2.02 (CI: 1.17-3.49) and high WC with an OR of 3.89 (CI: 2.06-7.36). Among women, the only relationship observed was between abdominal obesity and very high CRP with an OR of 2. 65 (CI: 1.20-5.84). Conclusions: Metabolic syndrome, high triglyceride levels, and abdominal obesity were associated with inflammation only in men.

Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults.

BACKGROUND: We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status. METHODS: One thousand one hundred ninety three Chilean adults subjects aged 22-28 living in a semi-rural area of central Chile answered a lifestyle and the European Community Respiratory Health Survey (ECRHS) questionnaires. Bronchial hyper-responsiveness (BHR) and skin prick test (SPT) to eight allergens were measured at baseline in 2001. Ten years later, 772 participants completed the questionnaires again. Estimates of adjusted net changes in prevalence of symptoms by sensitization status at baseline and association between sensitization status at baseline and respiratory symptoms ten years later were assessed. RESULTS: A quarter of the participants were sensitized to at least one allergen in 2001. Prevalence of wheeze had a net change per year of -0.37 % (95 % Confidence Interval -0.71 to 0.02 %; p = 0.067). Self-reported nasal allergies in the last 12 months increased by 0.83 % per year (95 % CI 0.49 to 1.17 %; p < 0.001). Those sensitized to either cat fur (OR 1.76; CI 1.01 to 3.05), cockroach, (OR 2.09; 1.13 to 3.86) blend of grass and pollens (1.78; 95 % CI 1.08 to 2.92), or weeds (OR 1.77; 95 % CI 1.01 to 3.12) in 2001 were more likely to have wheeze in the last 12 months 10 years later. CONCLUSION: Symptoms of asthma remained stable or slightly changed over 10 years in adults, whilst rhinitis and nasal allergies greatly increased. Being sensitized to at least one allergen is a risk factor for persistent symptoms of asthma and rhinitis, but not for determining net changes of symptoms over time. The underlying causes for the contrasting trends between asthma and nasal allergy are unknown.

Does the association between birth weight and blood pressure increase with age? A longitudinal study in young adults.

OBJECTIVES: To assess whether the association between birth weight and blood pressure (BP) increases with age using three different statistical methods. METHODS: A representative sample of 1232 study participants born between 1974-1978 in Limache, Chile were assessed in 2000-2002, of whom 796 were reassessed in 2010-2012. An 'amplification effect' was assessed by the change in the ß coefficient in the two periods, the association between birth weight and the difference of BP overtime, and the interaction between birth weight and BP in the two periods. RESULTS: Birth weight was negatively associated with SBP in 2000-2002 (ß = -2.46, 95% confidence interval (CI) -3.77 to -1.16) and in 2010-2012 (ß = -3.64, 95% CI -5.20 to -2.08), and with DBP in 2000-2002 (ß = -1.26, 95% CI -2.23 to -0.29) , and 2010-2012 (ß = -1.64, 95% CI -2.84 to -0.45) after adjustment for sex, physical activity, and BMI. There was no association between birth weight and the difference in BP between the two periods or the interaction between birth weight, BP, and time interval. CONCLUSION: Birth weight is a factor associated with BP in adults. This association increased with age, but amplification was shown only with one of the three methods.

Indigenous and tribal peoples' health (The Lancet-Lowitja Institute Global Collaboration): a population study.

BACKGROUND: International studies of the health of Indigenous and tribal peoples provide important public health insights. Reliable data are required for the development of policy and health services. Previous studies document poorer outcomes for Indigenous peoples compared with benchmark populations, but have been restricted in their coverage of countries or the range of health indicators. Our objective is to describe the health and social status of Indigenous and tribal peoples relative to benchmark populations from a sample of countries. METHODS: Collaborators with expertise in Indigenous health data systems were identified for each country. Data were obtained for population, life expectancy at birth, infant mortality, low and high birthweight, maternal mortality, nutritional status, educational attainment, and economic status. Data sources consisted of governmental data, data from non-governmental organisations such as UNICEF, and other research. Absolute and relative differences were calculated. FINDINGS: Our data (23 countries, 28 populations) provide evidence of poorer health and social outcomes for Indigenous peoples than for non-Indigenous populations. However, this is not uniformly the case, and the size of the rate difference varies. We document poorer outcomes for Indigenous populations for: life expectancy at birth for 16 of 18 populations with a difference greater than 1 year in 15 populations; infant mortality rate for 18 of 19 populations with a rate difference greater than one per 1000 livebirths in 16 populations; maternal mortality in ten populations; low birthweight with the rate difference greater than 2% in three populations; high birthweight with the rate difference greater than 2% in one population; child malnutrition for ten of 16 populations with a difference greater than 10% in five populations; child obesity for eight of 12 populations with a difference greater than 5% in four populations; adult obesity for seven of 13 populations with a difference greater than 10% in four populations; educational attainment for 26 of 27 populations with a difference greater than 1% in 24 populations; and economic status for 15 of 18 populations with a difference greater than 1% in 14 populations. INTERPRETATION: We systematically collated data across a broader sample of countries and indicators than done in previous studies. Taking into account the UN Sustainable Development Goals, we recommend that national governments develop targeted policy responses to Indigenous health, improving access to health services, and Indigenous data within national surveillance systems. FUNDING: The Lowitja Institute.

[Association of C reactive protein levels with metabolic syndrome in adults: a population-based study]. / Síndrome metabólico e inflamación en adultos: Un estudio poblacional.

BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP. This parameter was classified as normal for values from 0 to 3 mg/L, high for values from 3.01 to 10 mg/L and very high for values > 10 mg/L. RESULTS: Median CRP was in the normal range (1.9 mg/L, interquartile range 0.7-5.2) and was higher among women than men (2.2 and 1.4 mg/L respectively, p < 0.01). Twenty seven percent of participants had MetS. One-fourth had high blood glucose values, one-third had high triglyceride levels and 28% had blood pressure values over those established as normal in MetS. Elevated waist circumference (WC) and low HDL cholesterol were found among almost 50% of participants. A relationship between MetS and high CRP was only found among men with an Odds ratio (OR) of 2.04 (95% confidence intervals (CI): 1.11-3.73). The same association was observed for high triglyceride levels with an OR of 2.02 (CI: 1.17-3.49) and high WC with an OR of 3.89 (CI: 2.06-7.36). Among women, the only relationship observed was between abdominal obesity and very high CRP with an OR of 2. 65 (CI: 1.20-5.84). CONCLUSIONS: Metabolic syndrome, high triglyceride levels, and abdominal obesity were associated with inflammation only in men.

[Fruit and vegetable intake, and blood pressure. A population research]. / Consumo de frutas, verduras y presión arterial. Un estudio poblacional.

Consuming fruits and vegetables is known to lower blood pressure. However, it is unclear how much should be consumed in order to achieve this effect. The aim of this study was to analyze the association between fruit and vegetable consumption and blood pressure. A cross-sectional study was conducted among a random sample of 777 adults between the ages of 32 and 38 from the Region of Valparaiso, Chile. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured, and a survey was carried out to quantify consumption trends over the past month. The fruit and vegetable intake was divided into three groups: less than 200 g, 200-400 g, and more than 400 g. In the analysis, multiple linear regression models were used and were adjusted for sex, BMI, physical activity, socioeconomic status, smoking, and sodium intake. It was observed that increasing intake of fruits and vegetables lowers the systolic blood pressure (ß = -3.37 , 95% CI : -6.45 to -0.29; for consumption between 200 and 400 g ) (ß = -4.02, 95% CI: -7.06 to -0.98; for consumption great than 400 g), while an effect on diastolic pressure is only seen in those who meet the WHO recommendation of consuming more than 400 g per day (ß -2.87, CI = -5.17 to -0.57). In conclusion, consuming fruits and vegetables in amounts larger than 400 g per day, provides a protective effect against increases in both systolic and diastolic blood pressure.

[Intake of sugar-sweetened non-alcoholic beverages and body mass index: A national sample of Chilean school children]. / Ingesta de bebidas azucaradas analcohólicas e índice de masa corporal en escolares chilenos.

OBJECTIVE: To estimate the association between the intake of sugar-sweetened non-alcoholic beverages and body mass index (BMI) in Chilean school children. MATERIALS AND METHODS: Food consumption frequency data were analyzed for school children aged 6 to 18. The association between consumption of sugar-sweetened beverages and BMI was estimated by multivariate lineal regression models. RESULTS: Sugar-sweetened beverages are consumed on a daily basis by 92% (95%CI:90-94) of subjects with daily intake medians of 424 mL (p25-p75:212-707). Every extra daily portion of sugar-sweetened beverages consumed by school children aged 6 to 13 is associated with 0.13 BMI z-scores (95%CI:0.04-0.2;p=0.01). CONCLUSIONS: School children consume sugar-sweetened beverages daily with intake medians close to 0.5L. There is an association between sugar-sweetened beverage consumption and higher BMI in Chilean school children.

[Secular variation of births, weight and length at birth: Local perspective]. / Variación secular de los nacimientos, peso y longitud al nacer: perspectiva local.

OBJECTIVE: To analyse the outcomes of births and anthropometric measurements at birth of children born between 1974 and 2011 at Limache Hospital (Valparaíso, Chile). PATIENTS AND METHOD: Times series were constructed of births, weight and length at birth, and low weight and length at birth. The trend was modelled with linear and logistical regressions using splines to represent breaks in the trend by decade. RESULTS: The series includes 17,574 births. There was an increase in births per year in the 1970s (30/year) and declines in them to 17 and 22 births/year in the 1980s and 1990s, respectively (P<.001), with no significant trend thereafter. Newborns from 2000 to 2011 weighed 266 grams more than those in the 1970s (P<.001), and have now reached a mean weight of 3,530 g. Low birthweight fell from 8% in the 1970s to 1.1% after 2000. Birth length increased by 1cm in the 37 years studied, with a reduction of low birth length from 7.6% to 2.1% during the period. CONCLUSION: Live births in the Limache Hospital declined, and anthropometric measurements at birth improved in the years analysed. This information is useful in developing interventions, taking into account the possible selection biases that could distort these estimates and their interpretation.

Variación secular de los nacimientos, peso y longitud al nacer: perspectiva local / Secular variation of births, weight and length at birth: Local perspective

Objetivo: Analizar la evolución de los nacimientos y medidas antropométricas al nacer entre 1974-2011 en el Hospital de Limache, Región de Valparaíso, Chile. Pacientes y métodos: Se construyeron series de tiempo de nacimientos, peso y longitud al nacer, peso y talla baja al nacer. Se modelaron las tendencias con regresiones multivariadas usándose splines para representar los cambios de tendencia por década. Resultados: La serie comprende 17.574 nacimientos. Hubo un aumento de los nacimientos/año en los 70 (30/año) y disminución de 17 y 22 nacimientos/año en los 80 y 90 (p < 0,001); después, sin tendencia significativa. Los recién nacidos entre 2000-2011 registran 266 g más que los de la década de los 70 (p < 0,001), alcanzando actualmente en promedio 3.530 g. El bajo peso al nacer disminuyó de 8% en los 70 a 1,1% después de 2000. La longitud al nacer incrementó 1 cm en 37 años, con disminución de la talla baja de 7,6% a 2,1% en el periodo estudiado. Conclusión: Los nacimientos en el Hospital de Limache disminuyeron y las medidas antropométricas al nacer mejoraron; sin embargo, hay que considerar los posibles sesgos que distorsionan estas estimaciones.

Objective: To analyse the outcomes of births and anthropometric measurements at birth of children born between 1974 and 2011 at Limache Hospital (Valparaíso, Chile). Patients and method: Times series were constructed of births, weight and length at birth, and low weight and length at birth. The trend was modelled with linear and logistical regressions using splines to represent breaks in the trend by decade. Results: The series includes 17,574 births. There was an increase in births per year in the 1970s (30/year) and declines in them to 17 and 22 births/year in the 1980s and 1990s, respectively (P < .001), with no significant trend thereafter. Newborns from 2000 to 2011 weighed 266 grams more than those in the 1970s (P < .001), and have now reached a mean weight of 3,530 g. Low birthweight fell from 8% in the 1970s to 1.1% after 2000. Birth length increased by 1 cm in the 37 years studied, with a reduction of low birth length from 7.6% to 2.1% during the period. Conclusion: Live births in the Limache Hospital declined, and anthropometric measurements at birth improved in the years analysed. This information is useful in developing interventions, taking into account the possible selection biases that could distort these estimates and their interpretation.