In-Utero exposure to potential sources of indoor air pollution and umbilical cord blood leukocyte telomere length.

Indoor air pollution (IAP) has been associated with various adverse health effects. However, the evidence regarding such an association with leukocyte telomere length (LTL) in cord blood samples is still scarce. Therefore, the present study aimed to assess the relationship between exposure to indicators of IAP and LTL in umbilical cord blood samples. This cross-sectional study was based on 188 mother-newborn pairs who participated in our study between 2020 and 2022 in Isfahan, Iran. Umbilical LTL was measured by quantitative real-time polymerase chain reaction (qRT-PCR) technique. Linear mixed-effect models were used to assess the relationship between IAP indicators and umbilical LTL, adjusted for relevant covariates. The median (interquartile range (IQR)) of umbilical LTL was 0.92 (0.47). In fully adjusted models, frequency of using degreasing spray during pregnancy (times per month) (ß = -0.047, 95% CI:0.09, -0.05, P-value = 0.02), using air freshener spray during pregnancy (ß = -0.26, 95% CI: -0.5, -0.02, P-value = 0.03) and frequency of using insecticides during pregnancy (times per month) (ß = -0.025, 95% CI: -0.047, -0.003, P-value = 0.02) were significantly associated with shorter umbilical LTL. There was a positive significant relationship between the frequency of using cleaning spray during pregnancy (times per month) with umbilical LTL (ß = 0.019, 95% CI: 0.005, 0.033, P-value = 0.01). Furthermore, the direct connection of the parking with home and the frequency of using barbecue (times per week) were marginally associated with shorter umbilical LTL. For other indicators of IAP, we did not observe any statistically significant associations. Overall, this study suggested a negative association between prenatal exposure to IAP during pregnancy and umbilical LTL.

Potential role of serum vitamin D as a risk factor in pediatric acute lymphoblastic leukemia.

Vitamin D deficiency/insufficiency (VDD, VDI) is common in children yet limited experience exists on the association of VDD and hematologic malignancies amongst this population. Therefore, this study aimed to compare serum vitamin D levels in children with acute lymphoblastic leukemia (ALL) and controls. Moreover, vitamin D levels is compared in subjects with and without relapse and evaluated as a prognostic factor for relapse-free survival (RFS). Children with newly diagnosed ALL were recruited as case group. Data on demographic variables as well as the dietary habits were collected by interview. In addition, serum 25(OH)D3 was measured. The case group was followed up for 36 months to assess RFS. Overall, 358 subjects were included in the study (n = 169 cases, n = 189 controls). The mean levels of 25(OH)D3 were 28.05 ± 18.87 and 28.76 ± 12.99 in cases and controls, respectively (p = .68). VDD was found in 15.4% (n = 26) and 4.2% (n = 8) of the case and control groups, respectively (p < .001). Relapse was seen in 18.34% of patients and vitamin D levels of 20 ng/mL or above were associated with longer RFS (p = .044 by log-rank test). In this study, VDD and VDI amongst children with ALL were significantly higher than controls. In addition, lower levels of Vitamin D were associated with increased risk of relapse.

Environmental Risk Factors for Pediatric Acute Leukemia: Methodology and Early Findings.

Background: Acute leukemia is the most common type of malignancy in children, and no major environmental risk factors have been identified relating to its pathogenesis. This study has been conducted with the aim for identifying risk factors associated with this disease. Methods: This study was conducted in 2016-2020 among children aged <15 years residing in Isfahan Province, Iran. Children with newly diagnosed Acute lymphoblastic leukemia, including Acute myeloid leukemia (ALL and AML) were considered a case group. The control group was selected among children hospitalized in orthopedic and surgery wards in the same region. Demographic data, parental occupational exposures and educational level, maternal obstetric history, type of feeding during infancy and parental smoking habits, exposure to pesticides, and hydrocarbons besides dietary habits (using a food frequency questionnaire) were evaluated. Results: Overall, 497 children (195 cases and 302 controls) completed the survey. In the initial analysis, there was no significant difference between case and control groups about type of milk feeding (P = 0.34) or parental age (P = 0.56); however, an association between mothers' education and increased risk for ALL was observed (P = 0.02). Conclusions: The results of this study can be helpful in better understanding the environmental risk factors involved in the incidence of acute leukemia. Future publications based on the analysis of the database created in the present study can lead to recognizing these factors. In addition, evaluating the effect of these factors on treatment outcomes is an important step in reducing the burden of the disease.

Evaluation of health risk of glyphosate pesticide intake via surface and subsurface water consumption: A deterministic and probabilistic approach.

As the usage of pesticides for both agricultural and non-agricultural uses increases, it is more important than ever to employ probabilistic methods rather than deterministic ones to calculate the danger to human health. The current work demonstrates the application of deterministic and probabilistic approaches to assess the human health risk related to glyphosate during the consumption of surface and groundwater by different population groups. To that aim, the concentration of glyphosate pesticide in the surface and groundwater was measured and human health risk for three population groups including children, teens, and adults was evaluated. Overall, the probabilistic approach via Monte Carlo simulation showed a valid result for the estimation of human health risk and determination of dominant input parameters.•The health risk of glyphosate exposure during water consumption for various population groups were evaluated using deterministic and probabilistic methods.•The modeling is performed by Crystal Ball (11.1.2.4) software, as open access software, and requires a limited number of inputs.•The probabilistic method could reliably assess the risks of glyphosate by considering the variability and uncertainty in input variables.

Association of Polycyclic Aromatic Hydrocarbons Urine Metabolites with Type 1 Diabetes.

Purpose: Polycyclic aromatic hydrocarbons (PAHs) are believed to be a possible factor in the development of cancer, ischemic heart disease, obesity, and cardiovascular disease. The objective of this study was to explore the association between certain metabolites of urinary PAH and type 1 diabetes (T1D). Methods: In Isfahan City, a case-control study was carried out involving 147 T1D patients and an equal number of healthy individuals. The study measured the levels of urinary metabolites of PAHs, specifically 1-hydroxynaphthalene, 2-hydroxynaphthalene, and 9-hydroxyphenanthrene, in both the case and control groups. The levels of these metabolites were then compared between the two groups to assess any potential association between the biomarkers and T1D. Results: The mean (SD) age of participants in the case and control groups was 8.4 (3.7) and 8.6 (3.7) years old, respectively, (P > 0.05). In terms of gender distribution, 49.7% and 46% of participants in the case and control groups were girls, respectively (P > 0.05). Geometric mean (95% CI) concentrations were: 36.3 (31.4-42) µg/g creatinine for 1-hydroxynaphthalene, 29.4 (25.6-33.8) µg/g creatinine for 2-hydroxynaphthalene, and 72.26 (63.3-82.5) µg/g creatinine for NAP metabolites. After controlling for variables such as the child's age, gender, maternal and paternal education, duration of breastfeeding, exposure to household passive smoking, formula feeding, cow's milk consumption, body mass index (BMI), and five dietary patterns, it was observed that individuals in the highest quartile of 2-hydroxynaphthalene and NAP metabolites had a significantly greater odd ratio for diabetes compared to those in the lowest quartile (P < 0.05). Conclusion: Based on the findings of this study, it is suggested that exposure to PAH might be linked to an increased risk of T1D in children and adolescents. To clarify a potential causal relationship related to these findings, further prospective studies are needed.

Health Risk Assessment of Exposure to Bisphenol A in Polymeric Baby Bottles.

In recent decades, paying attention to bisphenol A (BPA), as one of the endocrine disruptor compounds, has increased due to its harmful effects. Although, scattered studies have been conducted in order to measure BPA concentration migrated into polymeric baby bottles in different countries of the world, there are no review studies and evaluation with a global perspective in the field of BPA risk. Some of these studies indicated the potential risks and estrogenic effects associated with BPA in babies' daily intake. For this purpose, we reviewed the information on the migration levels of BPA into baby bottles has been reported in 10 countries. The potential risks associated with BPA through the daily intake as well as the estrogenic effect on 3 age groups of babies which include 0 to 6, 6 to 12, and 12 to 24 months were analyzed using the Monte Carlo simulation. Also, kinetic models were applied to predict the kinetics of the migration process of BPA. The median daily intake for 3 age groups was obtained as 191.1, 161.37, and 153.76 µg/kg/day, respectively; which indicated Hazard Index (HI) > 1. The median estrogenic effect for the 3 groups was estimated to be 0.021 ngE2/L. The kinetics of contaminant transfer with Polynomial model at 2 temperatures of 24°C and 40°C showed a better fit with R 2 = 0.99 and 0.91, respectively. Based on the risk assessment analysis conducted in the present study, the BPA migration in baby bottles appeared to be a health concern for babies. Therefore, it is needed to increase the safety level of bottles for babies as they are sensitive and vulnerable members of every society. Furthermore, in this study, only the investigation of the global situation of BPA in polymeric baby bottles was stated; therefore, more investigation about another potential sources of BPA in food chain is needed.

Biomonitoring of organochlorine pesticides and cancer survival: a population-based study.

Organochlorine pesticides (OCPs) are endocrine-disrupting chemicals (EDCs) that even at very low levels can cause cancer by increasing the activity of tumor cells and suppressing the immune system. There is also little information on OCPs and survival after diagnosis. The aim of this study was to monitor the concentration of OCPs in the blood serum of cancer patients and its relationship with their socio-demographic characteristics and ultimately that impact on survival time and hazard ratio (HR). This cross-sectional study included 89 diagnosed patients with cancer in Isfahan, Iran. 12 types of OCPs were measured in serum by gas chromatography (7GC) with an electron capture detector and equipped with mass spectrometer (MS). Also, participants' questionnaire was completed to collect information. T-test, ANOVA, and Chi-square tests were used to evaluate the association between serum levels of OCPs and quantitative and qualitative information of patients. Survival analysis was also examined based on Kaplan-Meier method, log-rank test, and Cox model. The mean of total OCPs in patients' serum was calculated to be 1.82 ± 1.36 µg/L. Concentration of 2,4' DDE had a significant relationship with body mass index (BMI) (kg/m2) (P < 0.05). In addition, gender revealed a significant correlation in estimating survival time (P < 0.05). Non-exposure to OCPs showed a positive effect on increasing the life expectancy of patients. Lindane and endosulfan increased the risk of death by 16% and 37%, respectively, with insignificant P value (P > 0.05). The findings of the present study showed adverse effects of OCPs on patients' survival time and increased mortality of HR. Moreover, as the first research conducted in the study area, it is suggested management of environmental, individual and social factors that could be influenced the biological accumulation of OCPs in humans and cause health promotion.

Concentrations of urinary parabens and reproductive hormones in Iranian women: Exposure and risk assessment.

Parabens are antimicrobial preservatives in a variety of processed foods and beverages, cosmetics, pharmaceuticals, and personal care products. Parabens may be associated with reproductive and endocrine disorders among women of reproductive age. The first objective of this study was to examine the association between urinary parabens concentrations and follicle-stimulating hormone(FSH), luteinizing hormone (LH), and prolactin disorders. The second objective of this study was to calculate the Hazard Quotient (HQ) and Margin of Exposure (MOE) to assess the potential risk for endocrine disrupts for each woman based on urinary paraben concentrations. To address these two objectives, a cross-sectional study was designed in the Imam Reza Hospital in Kermanshah. The association between early morning urinary paraben concentrations and the serum of fasting blood specimens was analyzed using multivariable linear regressions adjusted for confounding variables (i.e., creatinine, age, body mass index, and time spent on physical activity). Among the 96 women who participated in the study, those with BMI> 25 and aged 18-40 years showed higher levels of total urinary parabens. The highest sum of urinary parabens (54,955.16 µg/L) was observed among the women who were using toothpaste several times per day. Almost all the parabens such as methyl paraben(MeP), ethyl paraben(EtP), propyl paraben(PrP), butyl paraben(BuP) had a positive and negative significant association with serum concentrations of FSH and LH (p-value < 0.05). However, no significant association was found between any of the four parabens and serum prolactin hormone (p-value > 0.05). The Margin of Exposure (MOE) approach calculated for all parabens (<10000) showed a potential risk in the studied population. The results suggested that parabens could adversely affect reproductive and endocrine systems in women. Further studies relying on long-term exposure to parabens are necessary to better understand the potential risk of the association between urinary parabens concentrations with reproductive hormones.

Health risk assessment of exposure to chlorpyrifos in pregnant women using deterministic and probabilistic approaches.

Since chlorpyrifos (CPF), a major organophosphorus pesticide, is widely used for agricultural and domestic purposes, thus, humans may be exposed to these toxic compounds through multiple sources. In recent years, significant concerns have been raised regarding the deleterious effects of exposure to CPF on human health, especially growing fetus. Therefore, in this study, we aimed to evaluate the health risks of exposure to CPF among pregnant women living in Isfahan province, Iran, using deterministic and probabilistic approaches. The urinary concentration of 3, 5, 6-trichloro-2-pyridinol (TCP), the most common metabolite of CPF, was measured as the biomarker of current exposure to CPF. For this purpose, spot urine samples were taken from 110 pregnant women and the urinary concentrations of TCP were quantified. The estimated daily intake and hazard quotient (HQ) for CPF exposure were measured according to the reference values set by World Health Organization (WHO) and United States Environmental Protection Agency (US EPA) for acute and chronic exposure to CPF. Based on the results, TCP was detected in more than 70% of samples (3.8 ± 2.72 µg/L). The estimated daily intake for some participants was found to be higher than the suggested reference dose by USEPA for chronic exposure to CPF. Furthermore, the HQ>1 was obtained for 20% of the study population in Monte-Carlo analysis using USEPA chronic reference dose, indicating that chronic toxic effects are expected at least for a part of the target population. Based on the findings, proper measures should be taken to reduce the exposure of Iranian pregnant women to CPF and resultant health risks.

Indoor radon measurement in buildings of a university campus in central Iran and estimation of its effective dose and health risk assessment.

Indoor radon is a serious health concern and contributes about 10% of deaths from lung cancer in the USA and Europe. In this study, radon and thoron levels of 20 multi-floor buildings on the campus of Isfahan University of Medical Sciences were measured in cold and hot seasons of a year. SARAD- RTM1688 radon and thoron monitor was used for measurement. The annual effective dose of radon exposure was also estimated for residences on the campus. The results showed that radon concentration was below the WHO guideline (100 Bq m- 3) in most of the buildings. The ranges of radon were from 3 ± 10% to 322 ± 15% Bq m- 3 in winter and from below the detectable level to 145 ± 8% Bq m- 3 in summer. Mostly, the radon concentration in the basement or ground floors was higher than upper floors, however, exceptions were observed in some locations. For thoron, no special trends were observed, and in the majority of buildings, its concentration was below the detectable level. However, in a few locations besides radon, thoron was also measured at a high level during both seasons. The average annual effective dose via radon exposure was estimated to be 0.261 ± 0.339 mSv y- 1. The mean excess lung cancer risk (ELCR) was estimated to be 0.10%. It was concluded that indoor air ventilation, buildings' flooring and construction materials, along with the geological structure of the ground could be the factors influencing the radon concentration inside the buildings. Thus, some applicable radon prevention and mitigation techniques were suggested.

Association of maternal exposure to bisphenol A with her ß-hCG level and neonatal anthropometric measures.

Bisphenol A (BPA) is one of the organic compounds that might interfere with estrogenic receptors, which would make difficulties in pregnancy hormones and fetal growth. Human chorionic gonadotropin (ß-hCG) is one of the important pregnancy hormones that might be affected by environmental pollutants. The aim of this study is to investigate the probable impacts of maternal exposure to BPA on anthropometric measures of newborns. This cross-sectional study was conducted in 2019-2020 in Isfahan, Iran. During the first trimester of pregnancy, we measured the urinary BPA concentration and serum ß-hCG level of 120 pregnant women, who were randomly selected from participants of a birth cohort. BPA concentration was measured using gas chromatography-mass spectrometry (GC-MS). Serum blood sample was derived and used for ß-hCG analysis. Anthropometric measurement of neonates was conducted at the time of birth. BPA and ß-hCG level were grouped by quartiles, and their associations with birth weight, height, and head circumference were tested using multiple linear regression model. The adjustment was done for urine creatinine, gender, and gestational age, as well as maternal age, body mass index, and education level. Data of 119 pairs of mothers and infants were available for the present study. The mean (SD) age of mothers was 29.19 (5.75) years; 56.3% of newborns were boys. Geometric mean of urinary BPA and ß-hCG concentrations were 0.36 ng/g crea. (creatinine) and 17736 mIU/ml, respectively. Across the BPA tertiles, the differences in mean values were not significant for none of the anthropometric measurements and gestational age (GA). Furthermore, no significant association existed between unadjusted and adjusted tertiles of BPA and ß-hCG with abovementioned birth outcomes. It seems that the non-significant association found in this study is because of low levels of urinary BPA levels than in other studies; the adverse effects on infants might be related to high concentration of BPA passed from placenta. Future longitudinal studies with large sample size are necessary to document the adverse health effects of maternal exposure to endocrine disruptor chemicals including BPA.

Application of UV/chlorine processes for the DR83:1 degradation from wastewater: Effect of coexisting anions.

In the present work, effect of coexisting anions on the degradation performance of UV/chlorine (UV/Cl) processes as an advanced oxidation treatment for the dye containing wastewater was investigated. The results showed that by increasing pH of the solution from 3 to 11, degradation efficiency of UV/Cl process was reduced from 96.2 ± 1.4% to 62.9 ± 3.1%. In the case of 100 mg/L of DR83:1, the removal efficiency was improved from 30.2 ± 1.5% to 93.3 ± 4.7% when the chlorine dose was increased from 100 to 1000 µM. The HCO3- and Br- ions were the main inhibitor and promotor anions responsible for the degradation of DR83:1. The relative contribution of Cl• was higher than that for HO• and UV, which was about three-times higher than that for HO•. The lowest and highest amounts of trihalomethanes were generated at acidic and alkaline conditions as well as low disinfection by products at low pH due to the generation of more HO• radicals at acidic pH in comparison to higher pH such that less intermediates were remained to react with chlorine.

Artificial intelligence modeling to predict transmembrane pressure in anaerobic membrane bioreactor-sequencing batch reactor during biohydrogen production.

The complex nature of wastewater treatment has led to search for alternative strategies such as different artificial intelligence (AI) techniques to model the various operational parameters. The present work is aimed at predicting the transmembrane pressure (TMP) as a key operational parameter in the case of anaerobic membrane bioreactor-sequencing batch reactor (AnMBR-SBR) during biohydrogen production using the adaptive neuro-fuzzy inference systems (ANFIS) and artificial neural network (ANN). In both the models, organic loading rates (OLR) ranging from 0.5 to 8.0 g COD/L/d, effluent pH (3.6-6.9), mixed liquor suspended solid (4.6-21.5 g/L) and mixed liquor volatile suspended solid (3.7-15.5 g/L) were used as the input parameters to test TMP as an output parameter. The ANFIS model was trained using the hybrid algorithms for TMP prediction. The higher prediction performance was obtained by using the Gauss membership function with four membership numbers. A back-propagation algorithm was also employed for the feed forward training of ANN model; the best structure was a Levenberg-Marquardt training algorithm with nine neurons in the hidden layer. By employing ANFIS and ANN models, relatively a good prediction of TMP was obtained with the R2 values of 0.93 and 0.88, respectively while the calculated mean square error for TMP in the ANFIS model (7.3 × 10-3) was lower than that of ANN model (8.02 × 10-3). The higher R2 and lower MSE values for the ANFIS model exhibited a better TMP prediction performance than the ANN model. Finally, it was observed that in the sensitivity analysis of ANN model, OLR was the most important input parameter on the variation of TMP.

Advanced oxidation of 4-chlorophenol via combined pulsed light and sulfate radicals methods: Effect of co-existing anions.

Pulsed light (PL) technology, which is based on photonic technology involves the application of broadband emission of light with short and high-power pulses is beginning to emerge for the treatment of wastes via advanced oxidation processes (AOP). The present work investigates the efficiency of PL as a light source for persulfate (PS) activation (PL/PS) and 4-chlorophenol)4-CP) degradation, an organic model pollutant. The influencing parameters on 4-CP degradation such as solution pH, reaction time, initial concentration of 4-CP, PS dose, pulse intensity and frequency, and distance from PL source are systematically investigated. With increasing pH from 3 to 9, the 4-CP degradation decreased from 49.79 ± 2.49 to 33.12 ± 1.66%. The 4-CP degradation followed the first order kinetics that was improved with increasing reaction time, PS dose, pulse intensity, frequency of pulse, and decreasing pH, initial 4-CP concentration and distance from the PL source. The presence of sulfate, chloride, and carbonate anions in the solution has the inhibitory effects on 4-CP degradation, while nitrate anion improved the performance of PL/PS system. In addition, presence of humic acid had an inhibitory effect on the PL/PS system, which led to a decrease of reaction rate constant and 4-CP degradation was performed in PL/PS system with OH, SO4-, O2- and 1O2 radicals. The contributions of OH and SO4- radicals were 46% and 51%, respectively for the 4-CP degradation and synergistic effect of PL/PS system showed a significant influence on 4-CP degradation while using a combination of PL and PS, suggesting that PL is an effective activator of PS.

Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents.

Introduction: Studies have proved that exposure of adults to phthalates might be related to cardiometabolic risk factors and changes in markers of oxidative stress. Such studies conducted on school-age children and adolescents are limited and fail to assess the simultaneous effect of phthalates on these risk factors and oxidative stress markers. Therefore, it was attempted to identify the relationship of urinary phthalate metabolites with cardiometabolic risk factors and oxidative stress markers in children and adolescents. Methods. In this cross-sectional study, 108 children and adolescents, living in Isfahan industrial city of Iran, were examined. Urine samples taken from the participants were analyzed for mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-exohexyl) phthalate (MEOHP), and mono-methyl phthalate (MMP). Results: Results showed that, among phthalate metabolites, MBP had the highest concentration, followed by MBzP, MEOHP, MEHHP, MEHP, and MMP. Concentrations of these metabolites had a significant relationship with some of the cardiometabolic risk factors including systolic blood pressure (SBP), fasting blood sugar (FBS), and triglycerides (TG) (p < 0.05). Furthermore, the crude and adjusted linear regression models indicated the significant association of phthalate metabolites with superoxide dismutase (SOD), malondialdehyde (MDA), and homeostasis model assessment of insulin resistance (HOMA-IR) (p < 0.05). Conclusion: Although urinary phthalate concentrations could not exactly reflect the long-term exposure level in the studied age groups, the consumption of phthalate-free products during childhood and adolescent development shall be assumed helpful in maintaining a healthy lifestyle. To confirm these findings and develop effective intervention strategies, it would be necessary to perform longitudinal studies on diverse population.

Enhanced removal of humic acid from aqueous solution by combined alternating current electrocoagulation and sulfate radical.

Application of alternating current in electrocoagulation and activation of persulfate (AEC-PS) for the effective removal of humic acid (HA) from aqueous solution was evaluated. In order to optimize the removal efficiency HA by the AEC-PS process, several influencing parameters such as pH, reaction time, PS dose, current density (CD), concentration of NaCl, initial concentration of HA, and coexisting cations and anions influence were investigated. From the batch experiments, the highest HA removal efficiency obtained was 99.4 ± 0.5% at pH of 5, reaction time of 25 min, CD of 4.5 mA/cm2, PS dose of 200 mg/L, and NaCl concentration of 0.75 g/L for an initial HA concentration of 30 mg/L. When CD increased from 1.25 to 4.5 mA/cm2, the HA removal efficiency was improved from 88.8 ± 4.4% to 96.1 ± 1.5%. In addition, the type of coexisting cations and anions exerted a significant role, leading to a reduction in the removal efficiency of HA. To investigate the dominant free activated radical, radical scavengers such as tert-butyl alcohol and ethanol were employed. It was observed that both OH and SO4- radicals substantially contributed to the removal of HA, and the contribution of SO4- radical was higher than that of OH radical, suggesting that AEC-PS process could serve as a novel and effective treatment technique for the removal of organic matters from aqueous sources.

Health risk assessment of potentially toxic elements intake via food crops consumption: Monte Carlo simulation-based probabilistic and heavy metal pollution index.

The aim of this study is to assess the content of heavy metals and their potential health risk in consumed food crops. To this end, the samples from vegetables, rice, potato, onion, and black tea were derived from high sales and commonly consumed types. The noncarcinogenic health risk of heavy metals to the adults, teens, and children was estimated by target hazard quotients (THQs) and hazard index (HI) calculation. Sensitivity and uncertainty analyses were carried out using Monte Carlo simulations. Heavy metal pollution index (HMI) was used for ranking noncarcinogenic heavy metal pollution in sampled food crops. THQs showed that noncarcinogenic health risks to the local population were largely related to As (0.71 for adults, 0.87 for teens, and 2.4 for children), Mn (0.43 for adults, 0.28 for teens, and 0.64 for children), and Mo (0.12 for adults, 0.02 for teens, and 0.4 for children). HI for individual food crops (HIΣfi) in terms of different populations showed that the highest HIΣfi was for children while the highest HIΣTea was for adults. The arrangement of the calculated HIΣfi along with its highest value was in the order of HIΣRice (3.71) > HIΣTea (0.39) > HIΣBeans (0.2) > HIΣVegetables (0.13) > HIΣOnion (0.12) > HIΣPotato (0.11). The value of HI for all sampled food crops based on their daily ingestion rate achieved by deterministic and probabilistic (Monte Carlo simulations) approaches for adults, teens, and children was 1.63, 1.28, and 1.87, 1.67, 4.51, and 2.48 respectively, and revealed that all populations are vulnerable to the significant noncarcinogenic health risks and children are at more risk. The sensitivity analysis revealed that the ingestion rate (IR) is the most influential factor that contributed to the total risk. The determined HMI showed no heavy metal pollution for all food crops, and rice had higher-order in HMI ranking. These results showed that heavy metals exposure due to food ingestion is a threat to human health and needs choosing a proper strategy to reduce heavy metal exposure.

Fabrication of activated carbon from pomegranate husk by dual consecutive chemical activation for 4-chlorophenol adsorption.

In the present work, the fabrication of activated carbon (AC) from pomegranate husk (PHAC) by dual consecutive activation processes with ZnCl2 and NaOH as a chemical agent was studied. After that, the synthesized PHAC was used for adsorption of 4-chlorophenol (4CP) as a highly toxic compound for the human health and the environment. Different analytical techniques characterized the synthesized PHAC using ZnCl2/NaOH. The isotherms of N2 adsorption and desorption showed that total pore volume (Vtotal) and specific surface area (SBET) of PHAC were 0.404 cm3/g and 811.12 m2/g, respectively. The 4CP adsorption by PHAC studies revealed that the highest 4CP removal efficiency was 100% and obtained at 50, 100, and 150 mg/L of 4CP concentration with 2.5 g/L of PHAC. Based on the batch experiments, the highest 4CP removal was achieved at pH 6, 2.5 g/L of PHAC, and contact time of 60 min. The 4CP adsorption data of equilibrium and kinetics were successfully fitted to Langmuir's isotherm and Avrami fractional order.

The association between familial and environmental factors and prevalence of congenital hypothyroidism in center of Iran.

The aim of this current study is to investigate the association between familial and environmental factors and prevalence of congenital hypothyroidism (CH) in Isfahan province. In this retrospective cohort study, data of the neonates referred for CH screening in different cities of Isfahan province were evaluated. Data regarding air and soil (lead, cadmium) pollutants were collected. The spatial association between mentioned environmental pollutants and prevalence of CH in different cities of Isfahan province was evaluated by using GIS software, and multilevel linear regression was used for evaluating the levels of environmental pollutants and neonates' serum TSH. During the study period, 389,945 neonates were screened, from which 934 diagnosed with CH (1 in 417 neonates).The prevalence rate of CH was ranged from < 20 in 10,000 live births to > 45 in 10,000 live births in different cities of Isfahan province. There was no any significant association between level of soil lead and cadmium and air pollutants with prevalence of CH in different cities of Isfahan province (P > 0.05).There was a significant positive association between soil cadmium and air pollution evaluated by air quality index (AQI) and level of screening serum TSH in CH patients. Considering the significant association between cadmium and AQI with first serum TSH, it is inferred that the interaction of genetic, autoimmune, familial, and environmental factors with each other could influence on neonatal thyroid function. It seems that the role of some mentioned component is more prominent which should be investigated in future researches.

Adsorption of 4-chlorophenol by magnetized activated carbon from pomegranate husk using dual stage chemical activation.

Separation under the influence of magnetic field has been widely explored to tackle environmental issues related to centrifuging and filtration. In this work, activated carbon produced from pomegranate husk (PHAC) using dual stage chemical activation was magnetized with iron salts and used for adsorption of 4-chlorophenol (4CP) from the synthetic wastewater. Adsorption experiments were conducted in batch mode to determine the removal efficiency of magnetized activated carbon pomegranate husk (MPHAC) as a function of initial 4CP concentration, solution pH, MPHAC dose, contact time, ionic strength, and temperature. The rough surface of MPHAC containing pores on the surface had a total pore volume of 0.623 cm3/g with a surface area of 1168 m2/g. The 4CP adsorption was highly dependent on ionic strength, solution pH, and temperature; the equilibrium was reached in 60 min of contact time. Kinetic models and equilibrium isotherms were employed to assess the fitness of adsorption data; results were fitted best with the Liu model giving maximum adsorption capacities of 446.89 ± 20.75 and 183.64 ± 17.85 mg/g for 1 and 2 g/L of MPHAC, respectively. For the investigation of the adsorption kinetics, Avrami fractionary-order model showed the best fit of the experimental data compared to other kinetic models.