RESUMO
BACKGROUND AND OBJECTIVE: Generally, protection against SARS-CoV-2 was assessed by the measurement of antibody titers against spike protein and receptor binding domain "RBD". Many global efforts lead to development of several vaccines based on various strategies. The aim of the present study was to evaluate the efficacy of Sputnik V vaccine among Sari healthcare staff population, Iran. METHODS: Seventy-nine health professional staffs that were vaccinated with two doses of Sputnik V vaccine were selected. The Immune response against spike and RBD proteins was evaluated by ELISA assays 3-4 weeks after second dose of vaccine injection. RESULTS: The results showed the antibody titers were raised after vaccination. Data analysis has also demonstrated that the efficacy of vaccine was not related to age, gender and previous infection of SARS-CoV-2. CONCLUSION: Sputnik V vaccine can lead to a protective response against COVID-19 infection in high percentage of the population. J. Med. Invest. 70 : 317-320, August, 2023.
