1.
Biochim Biophys Acta
; 1627(2-3): 85-9, 2003 Jun 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12818426
RESUMO
The Dexras1 gene responds to glucocorticoids with a rapid and profound induction. A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. This element conferred rapid glucocorticoid responsiveness when inserted into a homologous promoter-driven luciferase reporter. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness.