RESUMO
OBJECTIVE: To investigate the relationship between the density of house dust mites allergens in bedroom and the attacks of allergic rhinitis in patients sensitive to mite. METHOD: Seventy-five houses (35 patients with allergic rhinitis and 30 healthy controls) were visited for dust sampling from mattresses, sofas, beddings and pillows. Der p1 and Der f1 levels were measured by ELISAs. RESULT: Der p1 and Der f1 levels in healthy control group were significantly higher than levels in patient group(P < 0.05). CONCLUSION: The amount of mite allergens might not be the determining factor for allergic rhinitis sensitization.
Assuntos
Alérgenos/análise , Antígenos de Dermatophagoides/efeitos adversos , Rinite Alérgica Perene/etiologia , Adulto , Animais , Antígenos de Dermatophagoides/análise , Feminino , Habitação , Humanos , Masculino , Pessoa de Meia-Idade , Rinite Alérgica Perene/prevenção & controleRESUMO
OBJECTIVE: Our purpose was to determine whether alleles at one or more HLA loci are associated with hypersensitivity to wormwood pollen in patients with allergic rhinitis. METHOD: By using PCR-SSP(sequence-specific primer polymerase chain reaction), we tested the frequency distribution of HLA-DQA1, DQB alleles in 41 patients with allergic rhinitis(AR) and 41 healthy controls from Beijing. RESULT: The frequency of HLA-DQA1* 0201, DQB1 * 0602 was lower in AR than in controls(24.39%, 4.88% vs 46.34%, 26.83%), and the frequency of DQA1 * 0302 was increased among patients(58.54% vs 14.63%). CONCLUSION: HLA-DQA1 * 0201, DQB1 * 0602 alleles might confer protection against AR, and DQA1 * 0302 may be a susceptibility factor for hypersensitivity to wormwood pollen.