Morphotype induced changes in the life history and population dynamics of an hippolytid shrimp.

One of the most exceptional, loud paradigm of shape polymorphisms constitutes the "rostral loss" condition in hippolytid shrimps. The intertidal shrimp Hippolyte sapphica includes two conspecific morphotypes, one of which demonstrates a neotenic rostrum (morph-B). Morphs' rostral elongation is controlled by a single genetic locus, with long rostra (morph-A) representing the recessive state and short, larval-like ones the completely dominant state. Geometrics morphometry on the species morphotypes revealed also the homozygous/heterozygous state of the gene site along with some induced body' adaptations, which compete the micro-evolutionary disadvantage of the "rostral loss". We found recently that females' viability and maternal energy investment selectively favors morph-A. The present contribution detects and discuss comparatively demographic and reproductive traits in species mixed (both morphs) and unmixed populations. Our results show that this sharp dimorphic rostral condition is a sex-related marker and that the species is gonochoric. Presence of morph-B results to (a) lower egg production (b) higher seasonally males' percentage (c) morph-A females' earlier maturation and (d) higher fecundity in morph-A mixed populations. It seems that the "rostral loss" state induces complex adaptations between the two morphotypes through sex ratios equilibria, morphotypes' growth rates, and morphs' fecundity differentiate inputs throughout the seasons.

Effects of α-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study.

Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. T2DM is associated with a number of pathological complications, including cardiovascular disease that is mostly promoted by the increased oxidative stress in type 2 diabetic patients. We performed a randomized double-blind placebo-controlled trial to investigate the effectiveness of an individualized oral supplementation with α-lipoic acid (ALA), carnosine, and thiamine. For that purpose, 82 obese type 2 diabetic patients were randomly assigned to 2 groups, and were either supplemented daily with 7 mg ALA/kg body weight, 6 mg carnosine/kg body weight, and 1 mg thiamine/kg body weight or placebo for 8 weeks. An array of biochemical tests including the estimation of oxidative stress and platelet aggregation were performed at baseline and at follow-up. Moreover, the antiplatelet activity of each of the supplement's components was determined ex vivo at human and washed rabbit platelets. Glucose and HbA1c levels were significantly reduced after supplementation (135.7 ± 19.5 mg/dL vs. 126.5 ± 16.8 mg/dL and 8.3% ± 0.3% vs. 6.03% ± 0.58%, respectively, P < .05); however, insulin was significantly increased (3.6 ± 0.7 µIU/mL vs. 6.8 ± 0.2 µIU/mL, P < .05). The patients treated with the supplement recorded higher follow-up values for HOMA-IR and HOMA-ß, and a significant drop in serum hydroperoxide level. Only ALA inhibited platelets aggregation ex vivo through ADP, platelet activating factor, arachidonic acid, epinephrine, collagen, and thrombin pathways. Daily supplementation with an individualized ALA, carnosine, and thiamine supplement effectively reduced glucose concentration in type 2 diabetic patients, probably by increasing insulin production from the pancreas. In addition to that, the reduction of oxidative stress and inhibition of platelet aggregation could potentially provide greater cardiovascular protection. Further studies are needed to fine-tune the supplementation dose-response effects in T2DM patients.