[Evaluation of alpha 1-antitrypsin phenotypes in Castilla-León: study of a population of newborn infants]. / Valoración de fenotipos de alfa 1-antitripsina en Castilla-León: estudio en una población de recién nacidos.

We have screened a population of newborn babies without any previous apparent pathology in order to discover the distribution of alpha 1-anti-trypsin phenotypes (AAT) in our community. The research has been done on 457 babies born in the province of Valladolid, determining the plasma levels of AAT and the corresponding phenotype. AAT quantification was done by nephelometry, and the phenotypic study was done by the technique described by Jeppsson. It has been possible to identify 8 different phenotypes, PIM being the one that had the highest incidence rate (72.42%), followed by PIMS (19.69%). In relation to the serum levels of AAT, the highest values were found for PIM (220 +/- 60 mg/dl) and the lowest for PIZ (43 +/- 2 mg/dl). Finally, the results obtained by our laboratory are compared with those of other authors.