Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model.

Mercury (Hg) and vitamin A (VitA) are two environmental factors with potential health impacts, especially during pregnancy and early childhood. Fish and seafood may present elevated levels of methylmercury (MeHg), the major Hg derivative, and VitA. This study aimed to evaluate the transgenerational effects of exposure to MeHg and/or VitA on epigenetic and toxicological parameters in a Wistar rat model. Our findings revealed persistent toxicological effects in generations F1 and F2 following low/mild doses of MeHg and/or VitA exposure during dams' (F0) gestation and breastfeeding. Toxicological effects observed in F2 included chronic DNA damage, bone marrow toxicity, altered microglial content, reduced neuronal signal, and diminished male longevity. Sex-specific patterns were also observed. Co-exposure to MeHg and VitA showed both synergistic and antagonistic effects. Additionally, the study demonstrated that MeHg and VitA affected histone methylation and caused consistent effects in F2. While MeHg exposure has been associated with transgenerational inheritance effects in other organisms, this study provides the first evidence of transgenerational inheritance of MeHg and VitA-induced toxicological effects in rodents. Although the exact mechanism is not yet fully understood, these findings suggest that MeHg and VitA may perpetuate their impacts across generations. The study highlights the need for remedial policies and interventions to mitigate the potential health problems faced by future generations exposed to MeHg or VitA. Further research is warranted to investigate the transgenerational effects beyond F2 and determine the matrilineal or patrilineal inheritance patterns.

A not so perfect plan: An examination of the differential influence of multidimensional perfectionism on missed and gained events during the COVID-19 pandemic.

During the COVID-19 pandemic, many individuals missed out on important life events, but it was also a chance for some to engage with new interests or values. This research examined how individuals higher in perfectionism experienced missed and gained events during the pandemic, and how their perceptions of these events influenced their mental health. University students (N = 350) were surveyed in September 2020, assessing perfectionism, depression, missed/gained events, and need satisfaction related to these events, and then followed up in December. A combined missed and gained event score was created to better understand overall need satisfaction from these changes. Individuals higher in self-critical perfectionism were more likely to experience need dissatisfaction overall and this partially explained why these individuals experienced more depressive symptoms over time during the pandemic. Conversely, those higher in personal standards perfectionism experienced more need satisfaction overall and this was related to reduced depressive symptoms. Results suggest that individuals higher in self-critical perfectionism were less flexible when things did not go according to their plan. This may be one reason these individuals had a more difficult time coping during the COVID-19 pandemic.