[The pharmacokinetics of fluorescein, hematoporphyrin and its derivative during the development of granuloma]. / Farmakokinetika fliuorestseina, gematoporfirina i ego proizvodnogo pri razvitii granulemy.

In experiments on rats with granuloma reproduced by subcutaneous implantation of foreign material there was shown a slowing of excretion from the organism as well as a considerable redistribution between the organs of fluorescein, hematoporphyrin and its derivative as compared with intact animals. The noted changes practically did not depend on the time of granuloma development.

[The pharmacokinetics of hematoporphyrin, its derivative and fluorescein during the development of carcinosarcoma]. / Farmakokinetika gematoporfirina, ego proizvodnogo i fliuorestseina pri razvitii kartsinosarkomy.

The pharmacokinetics of fluorescein, hematoporphyrin and a derivative of hematoporphyrin was studied microspectrofluorometrically on rats with transplanted carcinosarcoma. It was shown that in the rats in contrast to intact animals the tissue concentration of fluorescein exhibits a general tendency towards an increase, that of hematoporphyrin towards a decrease and that of hematoporphyrin derivative towards an increase in all parenchymatous organs and a decrease in the skin and mucosae of the hollow organs. At the equally short period of the maximal accumulation of luminophores, the tumour tissue differs from the normal one by a pronounced delay of excretion only of hematoporphyrin derivative.

[Pathogenesis of porphyrin-sensitized lethal and sub-lethal photo-injury]. / Patogenez sensibilizirovannogo porfirinami letal'nogo i subletal'nogo fotopovrezhdeniia.

By means of morphological methods the mechanisms of thanatogenesis were studied in 57 white mice after the hematoporphyrin derivative administration and xenon lamp radiation imitating the sun spectrum. In dependence of integrative doses of sensitized photoradiation and individual resistance of the organism there was observed immediate (hours), retained (days) and remote (weeks) death of animals. In the first two groups death came as a result of photocoagulation of plasma proteins and toxemic shock with liver, lung and brain injury, and in the third group--as a result of suppurative resorptive intoxication against the background of ulcerous skin necrosis.