HEIGHT AND WEIGHT CHARACTERISTICS OF MILITARY SERVICEMEN OF MOBILIZATION AGE WITH DISEASES OF THE CARDIOVASCULARY SYSTEM.

OBJECTIVE: The aim establish the height and weight characteristics of servicemen of mobilization age with cardiovascular diseases, the frequency and etiological fraction of excess body weight and obesity in the risk of developing cardiovascular diseases. PATIENTS AND METHODS: Materials and methods: The study included military personnel, exclusively male (n=127), who made up the observation group. The age of the study participants varied from 19 to 64 years, the average age - 43.06±4.07. All study participants were undergoing inpatient examination and treatment with cardiovascular diseases. The material for the study was the results of anthropological examinations and data from primary accounting medical documentation (medical history, primary medical card, evacuation ticket, etc.). RESULTS: Results: It was established that the prevalence of obesity in the observation group was 26.0%, which is significantly higher compared to the frequency of obesity in the control group of 13.2% (χ2=17.02; P=0.0003). It was found that obesity of the III stage degree occurred significantly more often in the experimental group - 3.03% compared to the control group - 0.4%, (χ2=5.73; #=0.01). The calculated value of the etiological share (EF of obesity) was equal to 51-66%, which indicates a high contribution of obesity to the development of cardiovascular diseases. CONCLUSION: Conclusions: It was established that the prevalence of obesity of various degrees among servicemen with diseases of the cardiovascular system is significantly higher compared to the frequency of obesity in the male population of Ukraine.

Bioethical problems arising in the study of single-nucleotide gene polymorphisms of occupational diseases.

In Ukraine, about 3 million people work in hazardous and dangerous conditions. The study of hereditary specificity in development of occupational diseases is being actively conducted through molecular genetic analysis of single-nucleotide gene polymorphisms. While studying single-nucleotide gene polymorphisms of occupational diseases, many complicated bioethical questions arise regarding the confidentiality of personal data, the choice between the profession chosen and the risk to one's own health. Complicated bioethical issues that arise when studying single-nucleotide gene polymorphisms of occupational diseases need to be actively discussed, not only by physicians, occupational pathologists, employers, scientists, but also by politicians and lawyers, taking into account ethical and social norms and implications.

THE IMPACT OF THE PANDEMIC LOCKDOWN ON AIR POLLUTION, HEALTH AND ECONOMIC GROWTH: SYSTEM DYNAMICS ANALYSIS.

OBJECTIVE: The aim of the paper is checking the hypothesis on the linking between consequences of pandemic lockdown and air pollution, public health, and economic growth. PATIENTS AND METHODS: Materials and methods: for prediction and modelling of the pandemic lockdown's impact on the air pollution, health, and economic growth with the system dynamics analysis and software Vensim; for the analysis, the authors used the methods as follows: bibliometric analysis with Scopus Tools Analysis and software VOSviewer. RESULTS: Results: The findings confirmed that the current rate of infected from growing disease was 11%. If quarantine continues the rate of infected from the growing disease will be 15%. If the quarantine cancels the rate of infected from the growing disease will be 5%, and the declining of GDP increment will be higher, than in scenario with quarantine. CONCLUSION: Conclusions: The findings confirmed the hypothesis that lockdown has the negative impact on the economic, social, and ecological growth of the country. At the same time, in the case, if the government cancel the quarantine, the declining of GDP increment will be higher, and the rate of infected from the growing disease will be the highest - 15%. In this case, the government should provide the quarantine regime and strengthen the control of the compliance.

Allelic polymorphisms of dna repair genes and their influence on the formation of resistance to the development of bronchopulmonary pathology under the action of industrial aerosols.

OBJECTIVE: Introduction: The frequency of alleles and genotypes of DNA repair genes in people working due to the influence of industrial aerosols (miners and workers of asbestos-cement plants (n = 215)) was studied. The aim of the work was to identify allelic polymorphisms affecting the formation of resistance or leading to an increased risk of developing bronchopulmonary pathology. PATIENTS AND METHODS: Materials and methods: In 90 patients with bronchopulmonary pathology and 125 persons working under the same conditions but without respiratory system diseases, the polymerase chain reaction in real time was determined by the polymorphisms of DNA repair genes: XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC1 ( rs25487) and XRCC3 (rs861539), ATM (rs664677), XRCC7 (rs7003908) and MLH1 (rs1799977). RESULTS: Results: In the course of this study the alleles and genotypes contributing to resistance to the development of respiratory system pathologies were determined: XRCC1•G/A (rs25487) (OR=0.57; 95% CI: 0.32-1.02; P≤0.040; Χ²=4.14); MLH1•A (rs1799977) (OR=0.62; 95% CI: 0.40-0.96; P≤0.020; Χ²=5.06); MLH1•A/A (rs1799977) (OR=0.43; 95% CI: 0.24-0.79; P≤0.003; Χ²=8.73). Also, we established the alleles and genotypes associated with the risk of developing bronchopulmonary pathology: XPD•C/C (rs13181) (OR=2.20, 95% CI: 1.02-4.77; P≤0.020; Χ²=4.85); XRCC1•A/A (rs25487) (OR=3.37; 95 % CI: 1.22-9.63; P≤0.008; Χ²=6.94); ATM•T/T (rs664677) (OR=2.48; 95% CI: 1.16-5.31; Р≤0.010; Χ²=6.61); MLH1•G (rs1799977) (OR=1.61; 95% CI: 1.04-2.49; P≤0.020; Χ²=5.06); MLH1•A/G (rs1799977) (OR=2.32; 95% CI: 1.29-4.21; P≤0.002; Χ²=9.01). CONCLUSION: Conclusions: The results indicate the influence of allelic polymorphisms of DNA repair genes on the formation of resistance to the development of bronchopulmonary pathology under the action of industrial aerosols and open up prospects for the development of modern preventive measures.