[Advances and prospects of a combined therapy of acute radiation injury in experiments]. / Dostizheniia i perspektivy kompleksnoi terapii ostroi luchevoi bolezni v éksperimente.

We present the results of a long-standing experimental development of ways and means for acute radiation sickness treatment that have been authorized for application in medicine and are mostly aimed at large-scale accidental injuries. The paper describes means for early treatment (prodigiosan, desoxynate, typhoid vaccine, proteus vaccine), a myeolopoiesis stimulant (estradiol dipropionate), a detoxication procedure (hemosorption), substitution therapy with bone marrow cells and peripheral blood mononuclears, anti-infectious schemes comprising antibiotics and polyvitamins.

[Radiation-protective action of microbial substances]. / Protivoluchevoe deistvie veshchestv mikrobnogo proiskhozhdeniia.

The referenced and our data on the radioprotective effect of microbial substances have been analysed. It was shown that Gram-negative microbe polysaccharides produce the maximum effect. The radioprotective mechanism of polysaccharides is considered in connection with their effect on the immune and hemopoietic systems.

[In vivo study of the functional activity of peripheral blood leukocytes of intact and irradiated dogs with an inactivation test of endogenous hemopoietic stem cells of sublethally irradiated mice]. / Issledovanie funktsional'noi aktivnosti leikotsitov perifericheskoi krovi intaktnykh i obluchennykh sobak in vivo v teste inaktivatsii éndogennykh krovetvornykh stvolovykh kletok subletal'no obluchennykh myshei.

Peripheral blood leukocytes of intact dogs, when transplanted to sublethally irradiated mice, have been found to suppress endogenous colony formation. The inactivation effect in hemopoietic stem cells of mice is enhanced with an increase in the number of effector cells in the graft. Radiation exposure results in failure of the effector function of leukocytic cells at the peak of acute radiation sickness. Nine months after irradiation, the inactivating capacity of dog leukocytes is restored and exceeds that of the control. Administered to dogs 9 months after irradiation, proteus vaccine stimulated the effector function of leukocytes at days 7 and 28 and suppressed it at days 14 and 62 post-administration.

[Biological effect of 9 GeV protons and the radioprotective effect of ATP and AMP on epithelial cells of the mouse cornea]. / Biologicheskoe deistvie protonov 9 GeV i radiozashchitnoe vliianie ATF i AMF na kletki épiteliia rogovitsy myshei.

The cytogenetic and cytological effects induced in mouse cornea epithelium cells by 9 GeV protons and "standard" radiation have been studied. The RBE coefficients are different at different times of observation. ATP and AMP are shown to produce a protective effect on the frequency of formation of aberrant mitoses. DMF values for protons determined 24 and 72 h following irradiation are 1.8 +/- 0.2 and 1.7 +/- 0.2, respectively.