RESUMO
The increased intake of omega-6 fatty acids together with the widely use of omega-3 supplements in Western diets can affect the host defence against infectious diseases. In the present review we focused on the impact of these fatty acids on salmonella and mycobacteria infection models in animals or in cell cultures. Particular attention was given to the molecular mechanisms involved.
Assuntos
Gorduras na Dieta/efeitos adversos , Gorduras na Dieta/farmacologia , Suscetibilidade a Doenças , Ácidos Graxos Ômega-3/efeitos adversos , Ácidos Graxos Ômega-3/farmacologia , Animais , Suscetibilidade a Doenças/dietoterapia , Ácidos Graxos Ômega-6/efeitos adversos , Ácidos Graxos Ômega-6/farmacologia , Humanos , Inflamação/dietoterapia , Inflamação/genética , Infecções por Salmonella/dietoterapia , Infecções por Salmonella/microbiologia , Tuberculose/dietoterapia , Tuberculose/microbiologiaRESUMO
A derivative of the temperate mycobacteriophage Ms6 containing the aph gene from transposon Tn5 was constructed. In the transductants the aph gene was integrated in the bacterial genome. The aph gene is stably maintained in the absence of positive selection after more than 150 generations. The results presented in this report show that Ms6 can be used as a vehicle for the integration of foreign DNA into the Mycobacterium smegmatis genome.
