Insights into the potential use of microRNAs as biomarker in cancer.

MicroRNAs (miRs) are small non-coding RNAs, which regulate gene expression profiles of several genes. Consequently, miRs control and regulate several vital cellular processes like proliferation, apoptosis, differentiation, etc. Not surprisingly, altered expression of miRs has been linked to cancer development and progression. Recent studies have shown that sufficiently stable miRs can be isolated from the serum and other body fluids of cancer patients. The distinct miR profiles in the cell free circulating fluids of cancer patients have a potential to become a new class of biomarkers to detect and prognosticate cancers. In this review, we first briefly address the biogenesis of miRs and their role in gene regulation. Subsequently, we highlighted the role of miRs in pathogenesis of diseases with an emphasis on cancers. Finally, since, miRs have been shown to be promising circulating biomarkers for cancer detection, we 1) summarize the work done to date and 2) highlight the most significant advances resulting from these studies.

An international basic science and clinical research summer program for medical students.

An important part of training the next generation of physicians is ensuring that they are exposed to the integral role that research plays in improving medical treatment. However, medical students often do not have sufficient time to be trained to carry out any projects in biomedical and clinical research. Many medical students also fail to understand and grasp translational research as an important concept today. In addition, since medical training is often an international affair whereby a medical student/resident/fellow will likely train in many different countries during his/her early training years, it is important to provide a learning environment whereby a young medical student experiences the unique challenges and value of an international educational experience. This article describes a program that bridges the gap between the basic and clinical research concepts in a unique international educational experience. After completing two semester curricula at Alfaisal University in Riyadh, Kingdom of Saudi Arabia, six medical students undertook a summer program at St. Boniface Hospital Research Centre, in Winnipeg, MB, Canada. The program lasted for 2 mo and addressed advanced training in basic science research topics in medicine such as cell isolation, functional assessment, and molecular techniques of analysis and manipulation as well as sessions on the conduct of clinical research trials, ethics, and intellectual property management. Programs such as these are essential to provide a base from which medical students can decide if research is an attractive career choice for them during their clinical practice in subsequent years. An innovative international summer research course for medical students is necessary to cater to the needs of the medical students in the 21st century.