Beam profile assessment in spectral CT scanners.

In this paper, we present a method that uses a combination of experimental and modeled data to assess properties of x-ray beam measured using a small-animal spectral scanner. The spatial properties of the beam profile are characterized by beam profile shape, the angular offset along the rotational axis, and the photon count difference between experimental and modeled data at the central beam axis. Temporal stability of the beam profile is assessed by measuring intra- and interscan count variations. The beam profile assessment method was evaluated on several spectral CT scanners equipped with Medipix3RX-based detectors. On a well-calibrated spectral CT scanner, we measured an integral count error of 0.5%, intrascan count variation of 0.1%, and an interscan count variation of less than 1%. The angular offset of the beam center ranged from 0.8° to 1.6° for the studied spectral CT scanners. We also demonstrate the capability of this method to identify poor performance of the system through analyzing the deviation of the experimental beam profile from the model. This technique can, therefore, aid in monitoring the system performance to obtain a robust spectral CT; providing the reliable quantitative images. Furthermore, the accurate offset parameters of a spectral scanner provided by this method allow us to incorporate a more realistic form of the photon distribution in the polychromatic-based image reconstruction models. Both improvements of the reliability of the system and accuracy of the volume reconstruction result in a better discrimination and quantification of the imaged materials.

Monte Carlo characterization of 169Yb as a high-dose-rate source for brachytherapy application by FLUKA code.

Higher initial dose rate and simplifying HDR room treatment of 169Yb element among other brachytherapy sources has led to investigating its feasibility as high-dose-rate seed. In this work, Monte Carlo calculation was performed to obtain dosimetric parameters of 169Yb, Model M42 source at different radial distances according to AAPM TG-43U1 and HEBD Report about HDR sources in both air vacuum and spherical homogeneous water phantom. The deposited energy resulted by FLUKA as Monte Carlo code using binning estimators around 169Yb source was converted into radial dose rate distribution in polar coordinates surrounding the brachytherapy source. The results indicate a dose rate constant of 1.14 ± 0.04 cGy.h(-1).U(-1) with approximate uncertainty of 0.04%, air kerma strength, 1.082± 2.6E-06 U.mCi(-1) and anisotropy function ranging from 0.386 to 1.00 for radial distances of 0.5-10 cm and polar angles of 0°-180°. Overall, FLUKA dosimetric outputs were benchmarked with those published by Cazeca et al. via MCNP5 as one of validate dosimetry datasets related to 169Yb HDR source. As a result, it seems that FLUKA code can be applicable as a valuable tool to Monte Carlo evaluation of novel HDR brachytherapy sources.