Structure, Optical and Magnetic Properties of Two Isomeric 2-Bromomethylpyridine Cu(II) Complexes [Cu(C6H9NBr)2(NO3)2] with Very Different Binding Motives.

Two isomeric 2-bromomethylpyridine Cu(II) complexes [Cu(C6H9NBr)2(NO3)2] with 2-bromo-5-methylpyridine (L1) and 2-bromo-4-methylpyridine (L2) were synthesized as air-stable blue materials in good yields. The crystal structures were different with [Cu(L1)2(NO3)2] (CuL1) crystallizing in the monoclinic space group P21/c, while the 4-methyl derivative CuL2 was solved and refined in triclinic P1¯. The orientation of the Br substituents in the molecular structure (anti (CuL1) vs. syn (CuL2) conformations) and the geometry around Cu(II) in an overall 4 + 2 distorted coordination was very different with two secondary (axially elongated) Cu-O bonds on each side of the CuN2O2 basal plane in CuL1 or both on one side in CuL2. The two Br substituents in CuL2 come quite close to the Cu(II) centers and to each other (Br⋯Br ~3.7 Å). Regardless of these differences, the thermal behavior (TG/DTA) of both materials is very similar with decomposition starting at around 160 °C and CuO as the final product. In contrast to this, FT-IR and Raman frequencies are markedly different for the two isomers and the UV-vis absorption spectra in solution show marked differences in the π-π* absorptions at 263 (CuL2) or 270 (CuL1) nm and in the ligand-to-metal charge transfer bands at around 320 nm which are pronounced for CuL1 with the higher symmetry at the Cu(II) center, but very weak for CuL2. The T-dependent susceptibility measurements also show very similar results (µeff = 1.98 µB for CuL1 and 2.00 µB for CuL2 and very small Curie-Weiss constants of about -1. The EPR spectra of both complexes show axial symmetry, very similar averaged g values of 2.123 and 2.125, respectively, and no hyper-fine splitting.

Polyethylenimine Grafted onto Nano-NiFe2O4@SiO2 for the Removal of CrO42-, Ni2+, and Pb2+ Ions from Aqueous Solutions.

Polyethyleneimine (PEI) has been reported to have good potential for the adsorption of metal ions. In this work, PEI was covalently bound to NiFe2O4@SiO2 nanoparticles to form the new adsorbent NiFe2O4@SiO2-PEI. The material allowed for magnetic separation and was characterized via powder X-ray diffraction (PXRD), showing the pattern of the NiFe2O4 core and an amorphous shell. Field emission scanning electron microscopy (FE-SEM) showed irregular shaped particles with sizes ranging from 50 to 100 nm, and energy-dispersive X-ray spectroscopy (EDX) showed high C and N contents of 36 and 39%, respectively. This large amount of PEI in the materials was confirmed by thermogravimetry-differential thermal analysis (TGA-DTA), showing a mass loss of about 80%. Fourier-transform IR spectroscopy (FT-IR) showed characteristic resonances of PEI dominating the spectrum. The adsorption of CrO42-, Ni2+, and Pb2+ ions from aqueous solutions was studied at different pH, temperatures, metal ion concentrations, and adsorbent dosages. The maximum adsorption capacities of 149.3, 156.7, and 161.3 mg/g were obtained for CrO42-, Ni2+, and Pb2+, respectively, under optimum conditions using 0.075 g of the adsorbent material at a 250 mg/L ion concentration, pH = 6.5, and room temperature.

The need for a standard for informed consent for collection of human fetal material.

The ISSCR has developed the Informed Consent Standards for Human Fetal Tissue Donation and Research to promote uniformity and transparency in tissue donation and collection. This standard is designed to assist those working with and overseeing the regulation of such tissue and reassure the wider community and public.

Process enhancing strategies for the reduction of Cr(VI) to Cr(III) via photocatalytic pathway.

This discourse aimed at providing insight into the strategies that can be adopted to boost the process of photoreduction of Cr(VI) to Cr(III). Cr(VI) is amongst the highly detestable pollutants; thus, its removal or reduction to an innocuous and more tolerable Cr(III) has been the focus. The high promise of photocatalysis hinged on the sustainability, low cost, simplicity, and zero sludge generation. Consequently, the present dissertation provided a comprehensive review of the process enhancement procedures that have been reported for the photoreduction of Cr(VI) to Cr(III). Premised on the findings from experimental studies on Cr(VI) reductions, the factors that enhanced the process were identified, dilated, and interrogated. While the salient reaction conditions for the process optimization include the degree of ionization of reacting medium, available photogenerated electrons, reactor ambience, type of semiconductors, surface area of semiconductor, hole scavengers, quantum efficiency, and competing reactions, the relevant process variables are photocatalyst dosage, initial Cr(VI) concentration, interfering ion, and organic load. In addition, the practicability of photoreduction of Cr(VI) to Cr(III) was explored according to the potential for photocatalyst recovery, reactivation, and reuse reaction conditions and the process variables.

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here.

A critical review on the occurrence of resistomes in the environment and their removal from wastewater using apposite treatment technologies: Limitations, successes and future improvement.

Recent reports are pointing towards the potential increasing risks of resistomes in human host. With no permissible limit in sight, resistomes are continually multiplying at an alarming rate in the ecosystem, with a disturbing level in drinking water source. The morphology and chemical constituent of resistomes afford them to resist degradation, elude membrane and counter ionic charge, thereby, rendering both conventional and advanced water and wastewater treatment inefficient. Water and wastewater matrix may govern the propagation of individual resistomes sub-type, co-selection and specific interaction towards precise condition may have enhanced the current challenge. This review covers recent reports (2011-2019) on the occurrence of ARB/ARGs and ease of spread of resistance genes in the aquatic ecosystem. The contributions of water matrix to the spread and mitigation, treatment options, via bulk removal or capture, and intracellular and extracellular DNA lysis were discussed. A complete summary of recent occurrences of ARB/ARGs, fate after disinfection and optimum conditions of individual treatment technology or in tandem, including process limitations, with a brief assessment of removal or degradation mechanism were highlighted.

Meet-U: Educating through research immersion.

We present a new educational initiative called Meet-U that aims to train students for collaborative work in computational biology and to bridge the gap between education and research. Meet-U mimics the setup of collaborative research projects and takes advantage of the most popular tools for collaborative work and of cloud computing. Students are grouped in teams of 4-5 people and have to realize a project from A to Z that answers a challenging question in biology. Meet-U promotes "coopetition," as the students collaborate within and across the teams and are also in competition with each other to develop the best final product. Meet-U fosters interactions between different actors of education and research through the organization of a meeting day, open to everyone, where the students present their work to a jury of researchers and jury members give research seminars. This very unique combination of education and research is strongly motivating for the students and provides a formidable opportunity for a scientific community to unite and increase its visibility. We report on our experience with Meet-U in two French universities with master's students in bioinformatics and modeling, with protein-protein docking as the subject of the course. Meet-U is easy to implement and can be straightforwardly transferred to other fields and/or universities. All the information and data are available at www.meet-u.org.