RESUMO
Immune checkpoint inhibitors have become a target for pharmacological research in lung cancer. Immune-related adverse events (irAEs) such as pneumonitis, colitis, hepatitis and endocrinopathies have been well characterized in immune checkpoint inhibitors, but coronary toxicities, like acute coronary syndrome, are poorly described. Herein, we report a possible acute coronary syndrome as immune-related adverse event in a lung cancer patient.
Assuntos
Síndrome Coronariana Aguda/induzido quimicamente , Antineoplásicos Imunológicos/efeitos adversos , Colite/induzido quimicamente , Neoplasias Pulmonares/tratamento farmacológico , Nivolumabe/efeitos adversos , Idoso , Humanos , Masculino , RecidivaRESUMO
No disponible
Assuntos
Masculino , Idoso , Humanos , Falha de Prótese , Fibrilação Ventricular/diagnóstico , Desfibriladores ImplantáveisRESUMO
We present a case of rupture of the balloon during percutaneous transluminal septal myocardial ablation with alcohol in a patient with hypertrophic obstructive cardiomyopathy. Rupture of the balloon caused reflux of alcohol into the left anterior descending artery. Angina, mild global hypokinesia of the left ventricle and advanced atrioventricular block were observed. Cardiac function recovered in a few minutes and peak creatine kinase was 526 U. Despite the restoration of sinus rhythm, there were episodes of complete atrioventricular block that made permanent pacemaker implantation necessary.
Assuntos
Cardiomiopatia Hipertrófica/cirurgia , Ablação por Cateter/efeitos adversos , Etanol/administração & dosagem , Bloqueio Cardíaco/etiologia , Septos Cardíacos/cirurgia , Vasos Coronários , Bloqueio Cardíaco/terapia , Humanos , Complicações Intraoperatórias , Masculino , Pessoa de Meia-Idade , Marca-Passo ArtificialRESUMO
Presentamos un caso de rotura del balón de oclusión septal durante el procedimiento de ablación con alcohol en un paciente con miocardiopatía hipertrófica obstructiva. La rotura causó reflujo de alcohol a la arteria descendente anterior y originó angina, leve hipocinesia global, transitoria de ventrículo izquierdo y bloqueo auriculoventricular avanzado. La función contráctil se recuperó en pocos minutos y el pico de creatincinasa fue de 526 U. A pesar de restaurarse el ritmo sinusal, hubo episodios de bloqueo auriculoventricular que obligaron al implante de marcapasos definitivo
We present a case of rupture of the balloon during percutaneous transluminal septal myocardial ablation with alcohol in a patient with hypertrophic obstructive cardiomyopathy. Rupture of the balloon caused reflux of alcohol into the left anterior descending artery. Angina, mild global hypokinesia of the left ventricle and advanced atrioventricular block were observed. Cardiac function recovered in a few minutes and peak creatine kinase was 526 U. Despite the restoration of sinus rhythm, there were episodes of complete atrioventricular block that made permanent pacemaker implantation necessary
