Prediction of pathological stage at radical prostatectomy: do commonly used prostate cancer nomograms apply to men from Far North Queensland?

BACKGROUND: Clinical nomograms are routinely used by urologists to predict pathological and clinical outcomes. Commonly used prostate cancer nomograms include Partin's tables and Memorial Sloan Kettering Cancer Centre (MSKCC) nomograms which were developed in high-volume centres in the United States. We aimed to assess whether these tools are valid for prostate cancer patients in Far North Queensland. METHODS: All patients undergoing radical prostatectomy in Cairns between August 2014 and September 2017 were identified. Preoperative data were entered into the online nomogram tools. The predicted probability of organ-confined (OC) disease, extra-prostatic extension (EPE) and seminal vesical invasion was compared to the observed outcomes. RESULTS: Preoperative clinical information was available for 290 patients. Partin's tables accurately estimated OC disease, EPE and seminal vesical invasion with the observed outcome plot overlying the ideal correlation curve. More patients in our cohort had OC disease than was predicted by the MSKCC nomogram; fewer patients had EPE that was predicted by the MSKCC nomogram. On logistic regression modelling, the area under the curve for MSKCC and Partin's were 0.751 and 0.706, respectively, suggesting both tests have good performance in predicting final pathological outcome for our population of patients with no statistical difference between the two nomograms (P = 0.29). CONCLUSION: The MSKCC preoperative nomogram and Partin's tables were both able to accurately predict pathological outcomes from preoperative clinical information in men from Far North Queensland, despite likely differences in population genetics and environmental exposures.

Male flexible cystoscopy: does waiting after insertion of topical anaesthetic lubricant improve patient comfort?

UNLABELLED: What's known on the subject? and What does the study add? Flexible cystoscopy is commonly performed. Several studies show that topical anaesthetic lubricant reduces patient discomfort, particularly with long lubricant retention times (15-25 min). No studies have specifically addressed whether a short, clinically manageable retention time provides any benefit over immediate cystoscopy. Our study demonstrates that delay by a 3-min interval provides no benefit to patients and a more expedient approach can be justified without compromising patient comfort. LAY-TERM SUMMARY: This prospective comparative trial randomizes 50 men to undergo flexible cystoscopy with insertion of local anaesthetic lubricant either immediately prior to cystoscope insertion or after a 3-min interval. Patients then report discomfort on a visual analogue scale. We show that there is no benefit to delay and therefore a more expedient approach can be justified. OBJECTIVE: • To determine whether a short, clinically manageable time delay between lubrication with topical local anaesthetic and insertion of the flexible cystoscope, vs immediate insertion, reduces discomfort in male patients. PATIENTS AND METHODS: • This was a prospective comparative trial. • Male patients undergoing simple flexible cystoscopy were randomized to undergo cystoscope insertion either immediately after lubrication with topical lignocaine gel or after a 3-min delay. • Patient-reported pain of the procedure was recorded on a visual analogue scale and data were statistically analysed. RESULTS: • Fifty male patients were randomized to cystoscope insertion either immediately following lubrication or after a 3-min delay. • Mean pain score in the immediate insertion group was 11.94 mm (95% confidence interval [CI] 7.53-16.36) compared with 10.52 mm (95% CI 6.24-14.80) in the 3-min delay group. • The mean difference between the two groups was 1.42 mm (95% CI -4.57 to 7.41, P= 0.64). CONCLUSION: • Findings show that patient comfort is similar between the two groups and therefore there is no benefit in delaying insertion by a 3-min interval. • Flexible cystoscopy is a well tolerated outpatient procedure.