[Physiology and mechanisms of blood circulation in vascular bed]. / Fizjologia i mechanizmy krazenia krwi w lozysku naczyniowym.

The Authors have presented the essential physiological aspects of the blood flow vital to all physicians considering use of the autohaemotransfusion, extracorporeal circulation, extrapulmonary oxygenation and controlled haemodilution.

[Ozone therapy in the management of respiratory failure after long term mechanical respiration]. / Leczenie mieszanina tlenowo-ozonowa niewydolnosci oddechowej po dlugotrwalej wentylacji mechanicznej respiratorem.

The authors apply ozonotherapy in treatment of respiratory failure after long term PEEP mechanical respiration. Ozonotherapy application improve pulmonary gas exchange, increase production of surfactant, alveoli elasticity, ozone bacterial vinecidal properties let apply this method in treatment of antibiotics resistant infections. Ozonotherapy application in patients with severe respiratory failure give a possibility for rescue human life.

[Some aspects of ozone therapy]. / Niektóre zagadnienia ozonoterapii.

Authors present ozone-biochemistry, describe ozone production and application method of oxygen-ozone mixture. Authors describe application pf ozone therapy to treatment of virus or bacteria diseases and others as well as contraindications to the ozone therapy, side effects. Authors evaluate also effects of ozone therapy.

Ozonotherapy.

The medical use of ozone intraarterially, subcutaneously, intramuscularly and externally and in autohaemotransfusion or as a gas introduced into body cavities, as well as drops, compresses or liquids for rinsing etc. brings about very good therapeutic results. Ozone exerts a positive effect on oxygen and nutrient supply of cells, it enhances immunological processes, inhibits inflammatory processes, has a bacterio-, fungi- and virusostatic action when there is impaired resistance to microorganisms, improves rheological properties of the blood and exhibits no side effects in patients. Consequently ozonotherapy may be regarded asan effective method of treatment.

[Effect of slow infusion of magnesium sulphate on changes of arterial blood pressure values in patients with ischemic heart disease]. / Wplyw powolnego wlewu siarczanu magnezu na zachowanie sie wartosci cisnienia tetniczego krwi u chorych z choroba niedokrwienna serca.

In the paper the influence is presented of magnesium sulphate infusion on the changes of arterial blood pressure values in cases of initial hypertension and normotension in patients with coronary heart disease. Twenty-six patients were studied in this aspect, with precise measurement of arterial blood pressure by non-invasive method after careful preliminary qualification. The measurements were carried out during magnesium sulphate infusion by intravenous route. It was found that the magnesium sulphate infusion normalized arterial blood pressure in cases of initial hypertension while it failed to reduce the initial arterial blood pressure in cases of normotension.

The influence of applying magnesium preparation on the content of chosen ions of human plasma.

We have analyzed the influence of the administration of the "Calcimag" preparation, containing Mg+2 and Ca+2 ions, on the content of chosen blood plasma ions: Mg+2, Na+, K+, CI-, Ca+2 and phosphorus subject to the age of the volunteers. The preparation was administrated three times a day one tablet. The tendency to the decrease of magnesium concentration in plasma has been noticed subject to the age of the individuals. The administration of magnesium-calcium preparation caused statistically significant increase of magnesium in plasma for persons with hypomagnesemia and slight but characteristic increase for those with normomagnesemia.

[Clinical assessment of treatment results for atherosclerotic ischemia of the lower extremities with intraarterial ozone injections]. / Ocena kliniczna skutecznosci leczenia miazdzycy zarostowej konczyn dotetniczym wstrzykiwaniem ozonu.

Ten injections of O3 into femoral arteries were administered to 50 patients with atherosclerotic ischemia of the lower extremities and to 49 diabetic patients. All patients were assessed clinically with the ankle-arm index, measurement of intermittent claudication distance prior to and after the treatment. The treatment showed a significant improvement in both groups manifested by an increase in ankle-arm index, and prolongation of the intermittent claudication distance by more than twice. The treatment of atherosclerotic ischemia of the lower extremities with O3 is both valuable and safe.

[Controversies regarding the use of 0.75% bupivacaine]. / Kontrowersje wokól stosowania 0.75% bupiwakainy.

Controversies are described regarding wide introduction of bupivacaine with raised concentration (0.75%) of the active components, which has been introduced in other countries in the strongest local anaesthetic agent used as yet but in early 1980s it has been withdrawn from several western countries in view of possible serious cardiovascular side effects. Presently, after a number of studies it been demonstrated that these suppositions were unfounded and the observed complication were due errors in anaesthesiological techniques and not to an exceptional cardiotoxicity of the drug.

[Preliminary report on using general ozone therapy in diseases of the posterior segment of the eye]. / Wstepne doniesienie o stosowaniu ozonoterapii ogólnej w schorzeniach tylnego bieguna galki ocznej.

Autotransfusion of ozone venous blood was performed in 174 patients, in 32 patients ozone was given intraarterially. General ++ozone therapy was used for the first time in Poland in the following ophthalmological conditions: retinal pigment dystrophy, glaucomatous optic atrophy, in optic neuritis, after injuries and in cases of unknown aetiology; in degenerative-atrophic changes of the choroid, in high myopia, in post-inflammatory cases, in other degenerative diseases and in bacterial corneal ulcerations. Ozone therapy in these conditions seems to be favourable especially when the pathological process is not extensive. One could observe an improvement of the visual acuity and of the visual field.

[Preliminary report on using therapeutic ozone in infectious conjunctivitis and keratitis and in corneal degeneration]. / Wstepne doniesienie o zastosowaniu ozonu leczniczego w schorzeniach zakaznych spojówki i rogówki oraz zwyrodnieniach rogówki.

The preliminary report presents the results of application of ozone preparation in form of ophthalmic drops in 89 patients (134 eyes). This preparation has been used in virus conjunctival and corneal diseases as well as in corneal degenerations after inflammatory conditions and chemical burns. One observed as acceleration of the regeneration processes in active inflammatory conditions of the anterior eye segment; instead the cases of leucoma and corneal opacities did not show any clinical effect.

[Mathematical analysis of relations between dose, level or volume of bupivacaine and various hemodynamic parameters in epidural anesthesia]. / Matematyczna ocena zaleznosci miedzy dawka, stezeniem lub objetoscia bupiwakainy a niektórymi parametrami hemodynamicznymi w znieczuleniu zewnatrzoponowym.

Changes in the basic, hemodynamic parameters during the first 30 minutes of epidural anesthesia in relation of the dose, concentration, and volume of bupivacaine used are discussed. It was found, that in a proper epidural anesthesia a significant effect on the value of basic hemodynamic parameters was exerted only by a volume of administered bupivacaine solution, whereas its concentration or dose do not play any significant role. However, further prospective studies are necessary to extend this observation on the wider population.

[Some hemostatic parameters after treatment with ozone in a group of patients with obliterative atherosclerosis of the lower extremities and in a group of patients with diabetes]. / Niektóre parametry hemostazy po leczeniu ozonem w grupie chorych na miazdzyce zarostowa tetnic konczyn dolnych oraz w grupie chorych na cukrzyce.

Basic hemostasis and fibrinolysis parameters have been analysed in the group of 35 patients with obliterative atherosclerosis and in 41 patients with diabetes mellitus treated with intra-arterial ozone in concentration of O2/O3 54 micrograms/cm3 O3. Assayed parameters were within normal values. However, a tendency to decreased blood coagulation following ozone therapy was more pronounced in patients with obliterative atheromatosis, than in these with diabetes mellitus.

[Ozone therapy and viscosity of blood and plasma, distance of intermittent claudication and certain biochemical components in patients with diabetes type II and ischemia of the lower extremities]. / Ozonoterapia a lepkosc krwi i osocza, dystans chromania przestankowego oraz niektóre skladniki biochemiczne krwi u chorych na cukrzyce typu II z choroba niedokrwienna konczyn dolnych.

Blood and plasma viscosity, total blood lipids, triglycerides, total cholesterol, free fatty acids, fibrinogen, hematocrit, and lipidogram were determined in patients with diabetes mellitus type II and coexisting symptoms of the obliterative arteriosclerosis of the lower limbs. Intermittent claudication distance has been measured parallel. The same tests have been carried out after ozone therapy. A significant improvement in the intermittent claudication and reduction in blood and plasma viscosity have been noted. There was statistically significant correlation between intermittent claudication decrease and blood viscosity reduction following ozone therapy.

[Ozone therapy and viscosity of blood and plasma, distance of intermittent claudication and certain biochemical plasma components in patients with occlusive arteriosclerosis of the lower limbs]. / Ozonoterapia a lepkosc krwi i osocza, dystans chromania przestankowego oraz niektóre skladniki biochemiczne osocza u chorych na miazdzyce zarostowa tetnic konczyn dolnych.

Blood and plasma viscosity, total lipids, triglycerides, total cholesterol, free fatty acids, fibrinogen, lipid-gram, and hematocrit were determined in 53 patients with occlusive arteriosclerosis in the lower limbs prior to and after ozone therapy. At the same time the distance of the intermittent claudication was measured. A significant prolongation of the distance walked painlessly, reduction in blood and plasma viscosity as well as the decrease in total cholesterol after therapy with ozone correlated with a decrease of the blood viscosity.

[Various parameters of lipid metabolism after intra-arterial injections of ozone in patients with ischemia of the lower extremities and diabetes mellitus]. / Niektóre parametry gospodarki lipidowej po dotetniczych wstrzyknieciach ozonu u chorych na chorobe niedo-krwienna konczyn dolnych oraz cukrzyce.

In 50 subjects with arteriosclerotic ischaemia of the lower extremities and 41 subjects with diabetes mellitus ozone was applied intra-arterially. Before and after the treatment serum lipids concentration was examined. In the group with arteriosclerotic ischemia significant decrease in cholesterol level and both his fractions was seen. Whereas in the group with diabetes the cholesterol LDL was significantly reduced. In both groups total lipids level serum was decreased. It suggests that ++ozone therapy set back the arteriosclerosis progress, normalized some parameters of lipid metabolism and improved HDL to LDL cholesterol fractions relationship.

[Treatment of Guillain-Barré syndrome by the method of fractionated plasma exchange with controlled hemodilution]. / Leczenie zespolu Guillaina-Barrego metoda frakcjonowanej wymiany osocza w hemodilucji sterowanej.

Plasma exchange under controlled haemodilution was tried in 9 patients with Guillain-Barré syndrome repeating the procedure at 24-hour intervals for from 7 to 17 times with a total exchange of plasma ranging from 2.0 to 4.9 litres. All patients had significant paresis or paralysis of all four extremities, and 3 had additionally respiratory failure. The criteria accepted for performing plasmapheresis included a very severe form of the disease and a steady progression of signs despite treatment with corticosteroids. Already after the first exchange of plasma arrest of disease progression was observed in all cases, and after the 2nd or 3rd exchange a progressing improvement began. Six patients regained the ability of walking within 4 to 8 weeks, all were discharged walking unaided. The obtained results suggest the conclusion that the therapeutic method used is a very effective way of treating severe cases of Guillain-Barré syndrome and should be used in these patients.