Imbalance between the cellular proliferation and death in harderian gland of female mice with hyperprolactinemia.

OBJECTIVE: To assess the impact of the metoclopramide-induced hyperprolactinemia in cellular death and proliferation in the harderian gland of female mice. METHODS: Twenty female mice were divided into two groups of 10 animals each and treated: 0.2 mL of saline solution (controls, Ctr) and 200 µg of metoclopramide (experimental, hyperprolactinemia), both for 50 consecutive days and at 12:00 a.m. On the 50th day, the female were euthanized, and the harderian glands were removed and processed for immunohistochemistry for detected ki67 and TUNEL method. Data were statistically analyzed by unpaired Student's t test (p<0.05). RESULTS: The harderian gland of the hyperprolactinemia group showed increase in the immunoexpression of Ki67 and TUNEL compared to the Ctr group (p<0.05), and there was no significant difference in the amount of porphyrin in the HPrl group compared to the Ctr group. CONCLUSION: The hyperprolactinemia led to increased cell death in the acini the harderian gland and cell proliferation in the stroma glandular, fact that suggesting a reduction process of cellular activity and fibrosis, which suggests impairment in the functioning of the lacrimal harderian.

Relação da oclusão dentária com a postura de cabeça em pacientes portadores de DTM / Relationship between dental occlusion and head-position in DTM patients

A postura corporal global interfere na posição da cabeça a qual por sua vez determina a postura da mandíbula e da língua na cavidade bucal, o que pode provocar transtornos na articulação temporomandibular. O propósito deste trabalho foi avaliar, por meio de fotogrametria, a correlação entre a postura corporal global e má oclusão em pacientes atendidos no Núcleo de Diagnóstico e Tratamento de DTM/ DMOP. Foram selecionados 30 pacientes com diagnóstico de transtorno da articulação temporomandibular, atendidos no Núcleo de Diagnóstico e Tratamento de DTM/ DMOP da Faculdade de Odontologia de Araçatuba, Unesp. Para avaliação da postura corporal global foi utilizada tela plástica transparente quadriculada em preto, medindo 2,00 x 0,70m, com quadriculado de 10x10cm e realizada fotografia digital de cada paciente utilizando-se máquina fotográfica digital DSC-S2000 Sony Cyber-shot 10.1 mega pixels, posicionada em tripé na altura da cicatriz umbilical, nivelado a 310 cm de distância da tela. Cada paciente foi avaliado e fotografado em quatro vistas: anterior, posterior, lateral direita e lateral esquerda. As análises posturais foram realizadas por um mesmo fisioterapeuta e a má oclusão igualmente por cirurgião-dentista calibrado. Os dados obtidos foram submetidos à análise estatística e permitiram concluir que: a) a postura centralizada da cabeça se mostrou predominante nos pacientes com relação molar de classe I; b) a postura anteriorizada da cabeça foi observada em todos os pacientes com má oclusão de classe II; c) a posição posteriorizada da cabeça foi observada em todos os pacientes com má oclusão de classe III

The body posture interferes with the overall position of the head which in turn determines the position of the jaw and tongue in the oral cavity, which can cause temporomandibular joint disorders. The purpose of this study was to evaluate, by means of photogrammetry, the correlation between overall body posture and malocclusion in patients treated at the Center for Diagnosis and Treatment of TMD / DMOP. Were selected 30 patients diagnosed with temporomandibular joint disorder, seen in the Center for Diagnosis and Treatment of TMD / DMOP School of Dentistry of Araçatuba, Unesp. To assess the overall body posture was used transparent plastic screen checkered in black, measuring 2.00 x 0.70 m with a grid and held 10x10cm digital photo of each patient using a digital camera DSC-S2000 Sony Cyber-shot 10.1 mega pixels, positioned on a tripod at the height of the umbilicus, capped at 310 cm from the screen. Each patient was evaluated and photographed in four views: anterior, posterior, lateral right and left side. Postural Analyses were performed by the same physiotherapist and malocclusion also calibrated by the dentist. The data were statistically analyzed and showed that: a) centralized head posture showed predominant in patients with Class I molar relationship; b) the forward head posture was observed in all patients with Class II malocclusion; c) the posterior position of the head was observed in all patients with class III malocclusion