1.
J Org Chem
; 68(8): 3363-5, 2003 Apr 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12688823
RESUMO
An expeditious one-pot synthesis of 5-substituted tetronic acids from aldehydes and terminal conjugated alkyne as starting materials is described. The entire process embodies two consecutive chemical events: a catalytic domino reaction to build the 1,3-dioxolane scaffolds 5 and a two-step acid-catalyzed trans-acetalization-lactonization reaction to furnish the tetronic acid derivatives 6.